Scientists test double punch against Tough-to-Treat blood cancer

NCT ID NCT05890352

Recruiting now Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding one of two new drugs (tazemetostat or zanubrutinib) to an existing two-drug therapy works better for controlling an aggressive type of blood cancer called large B-cell lymphoma. It is for adults whose cancer has returned or did not respond to earlier treatments and who are not candidates for a stem cell transplant. The main goal is to see if the new combinations help keep the cancer from growing for a longer time and improve patients' quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aurora Bay Area Medical Group-Marinette
RECRUITING

Marinette, Wisconsin, 54143, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora BayCare Medical Center
RECRUITING

Green Bay, Wisconsin, 54311, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Cancer Care-Grafton
RECRUITING

Grafton, Wisconsin, 53024, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Cancer Care-Kenosha South
RECRUITING

Kenosha, Wisconsin, 53142, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Cancer Care-Milwaukee
RECRUITING

Milwaukee, Wisconsin, 53209, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Cancer Care-Milwaukee West
RECRUITING

Wauwatosa, Wisconsin, 53226, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Cancer Care-Racine
RECRUITING

Racine, Wisconsin, 53406, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Cancer Care-Southern Lakes VLCC
RECRUITING

Burlington, Wisconsin, 53105, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Health Care Germantown Health Center
RECRUITING

Germantown, Wisconsin, 53022, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Medical Center in Summit
RECRUITING

Summit, Wisconsin, 53066, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Saint Luke's Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora Sinai Medical Center
RECRUITING

Milwaukee, Wisconsin, 53233, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Aurora West Allis Medical Center
RECRUITING

West Allis, Wisconsin, 53227, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States

Contact

Contact Email: •••••@•••••
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77030, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Ben Taub General Hospital
RECRUITING

Houston, Texas, 77030, United States

Contact

Contact Phone: •••-•••-••••
Cancer Hematology Centers - Flint
RECRUITING

Flint, Michigan, 48503, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact

Contact Phone: •••-•••-••••
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
City of Hope Antelope Valley
RECRUITING

Lancaster, California, 93534, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
City of Hope Newport Beach
RECRUITING

Newport Beach, California, 92660, United States

Contact

Contact Phone: •••-•••-••••
City of Hope Seacliff
RECRUITING

Huntington Beach, California, 92648, United States

Contact

Contact Phone: •••-•••-••••
City of Hope South Bay
RECRUITING

Torrance, California, 90503, United States

Contact

Contact Phone: •••-•••-••••
City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
City of Hope Upland
RECRUITING

Upland, California, 91786, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
City of Hope at Long Beach Elm
RECRUITING

Long Beach, California, 90813, United States

Contact

Contact Phone: •••-•••-••••
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States

Contact

Contact Phone: •••-•••-••••
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Genesee Hematology Oncology PC
SUSPENDED

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Holy Cross Hospital
RECRUITING

Fort Lauderdale, Florida, 33308, United States

Contact Email: •••••@•••••

Contact
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Huron Gastroenterology PC
RECRUITING

Ypsilanti, Michigan, 48106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States

Contact

Contact Phone: •••-•••-••••
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mount Sinai Medical Center
SUSPENDED

Miami Beach, Florida, 33140, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Northwest Cancer Center - Hobart
RECRUITING

Hobart, Indiana, 46342, United States

Contact Phone: •••-•••-••••

Contact
Northwest Cancer Center - Main Campus
RECRUITING

Crown Point, Indiana, 46307, United States

Contact Phone: •••-•••-••••

Contact
Northwest Cancer Center - Valparaiso
RECRUITING

Valparaiso, Indiana, 46383, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Northwest Oncology LLC
RECRUITING

Dyer, Indiana, 46311, United States

Contact Phone: •••-•••-••••

Contact
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States

Contact

Contact Phone: •••-•••-••••
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Catherine Hospital
RECRUITING

Indianapolis, Indiana, 46312, United States

Contact Email: •••••@•••••

Contact
Saint Mary Medical Center
RECRUITING

Hobart, Indiana, 46342, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Community Hospital
RECRUITING

Munster, Indiana, 46321, United States

Contact Phone: •••-•••-••••

Contact
ThedaCare Regional Cancer Center
RECRUITING

Appleton, Wisconsin, 54911, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Tower Cancer Research Foundation
RECRUITING

Beverly Hills, California, 90211, United States

Contact

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
UC Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Ankeny Clinic
SUSPENDED

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
SUSPENDED

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
SUSPENDED

Clive, Iowa, 50325, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States

Contact

Contact Email: •••••@•••••
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States

Contact

Contact Phone: •••-•••-••••
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States

Contact

Contact Phone: •••-•••-••••
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of Rochester
RECRUITING

Rochester, New York, 14642, United States

Contact

Contact Phone: •••-•••-••••
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States

Contact Email: •••••@•••••

Contact
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Vince Lombardi Cancer Clinic - Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Vince Lombardi Cancer Clinic-Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Vince Lombardi Cancer Clinic-Two Rivers
RECRUITING

Two Rivers, Wisconsin, 54241, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

Contact

Contact Email: •••••@•••••
Women's Diagnostic Center - Munster
RECRUITING

Munster, Indiana, 46321, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

Conditions

Explore the condition pages connected to this study.

GRADE 3B FOLLICULAR LYMPHOMA HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 AND/OR BCL6 REARRANGEMENTS HIGH-GRADE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA TRANSFORMED NON-HODGKIN LYMPHOMA