New hope for Tough-to-Treat lung cancer: phase 3 trial tests promising drug

NCT ID NCT07291037

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new targeted drug called datopotamab deruxtecan works better than the standard chemotherapy (docetaxel) for people with advanced non-squamous lung cancer that has worsened after initial treatment. It will enroll 400 participants whose cancer tests positive for a specific marker called TROP2 and who have no other treatable genetic mutations. The main goals are to see if the new drug helps patients live longer without their cancer getting worse and improves overall survival.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

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Chandler, Arizona, 85224, United States
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Gilbert, Arizona, 85234, United States
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Goodyear, Arizona, 85338, United States
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Duarte, California, 91010, United States
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Irvine, California, 92618, United States
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La Jolla, California, 92093, United States
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Loma Linda, California, 92350, United States
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Los Angeles, California, 90095, United States
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San Diego, California, 92123, United States
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Grand Junction, Colorado, 81501, United States
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Wheat Ridge, Colorado, 80033, United States
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Newark, Delaware, 19713, United States
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Washington D.C., District of Columbia, 20037, United States
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Fort Myers, Florida, 33901, United States
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Jacksonville, Florida, 32224, United States
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St. Petersburg, Florida, 33709, United States
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Tampa, Florida, 33612, United States
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West Palm Beach, Florida, 33401, United States
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Marietta, Georgia, 30060, United States
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Newnan, Georgia, 30265, United States
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Chicago, Illinois, 60612, United States
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Chicago, Illinois, 60637, United States
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Niles, Illinois, 60714, United States
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Zion, Illinois, 60099, United States
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Louisville, Kentucky, 40207, United States
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South Portland, Maine, 04106, United States
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Baltimore, Maryland, 21201, United States
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Brandywine, Maryland, 20613, United States
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Boston, Massachusetts, 02215, United States
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Detroit, Michigan, 48202, United States
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Rochester, Minnesota, 55905, United States
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Bridgeton, Missouri, 63044, United States
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Columbia, Missouri, 65212, United States
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Lincoln, Nebraska, 68516, United States
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Albuquerque, New Mexico, 87109, United States
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East Syracuse, New York, 13057, United States
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Portland, Oregon, 97239, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19104, United States
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Greenville, South Carolina, 29607, United States
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Memphis, Tennessee, 38120, United States
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Austin, Texas, 78745, United States
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Denton, Texas, 76201, United States
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Plano, Texas, 75075, United States
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Charlottesville, Virginia, 22908, United States
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Fairfax, Virginia, 22031, United States
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Williamsburg, Virginia, 23188, United States
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Tacoma, Washington, 98405, United States
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Morgantown, West Virginia, 26506, United States
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Eau Claire, Wisconsin, 54703, United States
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Gosford, 2250, Australia
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Kogarah, 2217, Australia
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South Brisbane, 4101, Australia
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St Albans, 3021, Australia
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Wollongong, 2500, Australia
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Graz, 8036, Austria
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Linz, 4021, Austria
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Rankweil, 6830, Austria
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Vienna, 1140, Austria
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Vienna, 1210, Austria
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Hasselt, 3500, Belgium
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La Louvière, 7100, Belgium
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Libramont-Chevigny, 6800, Belgium
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Namur, 5000, Belgium
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Sint-Niklaas, 9100, Belgium
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Porto Alegre, 90610-000, Brazil
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Porto Alegre, 91350-200, Brazil
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Salvador, 40170-110, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 05652-900, Brazil
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Vancouver, British Columbia, VSZ 4E6, Canada
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Moncton, New Brunswick, E1C 6Z8, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Hamilton, Ontario, L8V 1C3, Canada
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Toronto, Ontario, M5G 1X6, Canada
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Beijing, 100034, China
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Beijing, 100142, China
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Beijing, 101149, China
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Changchun, 130000, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chongqing, 400030, China
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Fuzhou, 350011, China
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Guangzhou, 510080, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230610, China
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Jiamusi, 154007, China
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Jinan, 250117, China
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Nanchang, 330006, China
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Nanjing, 2100008, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Shanghai, 200433, China
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Shantou, 515041, China
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Shenyang, 110004, China
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Tianjin, 300050, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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Xuzhou, 221009, China
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Zhengzhou, 450008, China
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Zhengzhou, 450052, China
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Bad Saarow, 15526, Germany
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Bielefeld, 33611, Germany
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Bonn, 53127, Germany
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Cologne, 51109, Germany
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Essen, 45147, Germany
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Frankfurt, 60488, Germany
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Freiburg im Breisgau, 79106, Germany
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Gauting, 82131, Germany
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Hamburg, 20251, Germany
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Heidelberg, 69126, Germany
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Krefeld, 47805, Germany
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Minden, 32429, Germany
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Oldenburg, 26121, Germany
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Troisdorf, 53840, Germany
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Velbert, 42551, Germany
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Budapest, 1083, Hungary
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Budapest, 1121, Hungary
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Budapest, 1145, Hungary
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Debrecen, 4032, Hungary
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Gyöngyös - Mátraháza, 3200, Hungary
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Győr, 9024, Hungary
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Gyula, 5703, Hungary
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Kecskemét, 6000, Hungary
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Törökbálint, 2045, Hungary
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Bangalore, 560027, India
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Kolkata, 700016, India
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Mumbai, 400012, India
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Nashik, 422011, India
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New Delhi, 11029, India
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Milan, 20141, Italy
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Milan, 20162, Italy
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Monza, 20052, Italy
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Orbassano, 10043, Italy
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Padua, 35128, Italy
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Rozzano, 20089, Italy
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Hiroshima, 734-8551, Japan
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Iwakuni-shi, 740-8510, Japan
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Kashiwa, 277-8577, Japan
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Kawasaki-shi, 216-8511, Japan
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Kyoto, 612-8555, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Osakasayama-shi, 589-8511, Japan
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Sendai, 981-0914, Japan
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Sunto-gun, 411-8777, Japan
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Yokohama, 241-8515, Japan
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Lodz, 93-338, Poland
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Olsztyn, 10-357, Poland
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Poznan, 60-569, Poland
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Warsaw, 02-781, Poland
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Goyang-si, 10408, South Korea
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Incheon, 21565, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 5505, South Korea
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Suwon, 16247, South Korea
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A Coruña, 15009, Spain
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Barcelona, 8035, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Seville, 41009, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 80756, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 73657, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 11490, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10300, Thailand
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Muang, 50200, Thailand
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Ankara, 06530, Turkey (Türkiye)
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Istanbul, 32098, Turkey (Türkiye)
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Huddersfield, HD3 3EA, United Kingdom
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London, SW10 9NH, United Kingdom
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London, SW170QT, United Kingdom
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Maidstone, ME16 9QQ, United Kingdom
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Norwich, NR4 7UY, United Kingdom
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Stoke-on-Trent, ST4 6QG, United Kingdom
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Vinh, 460000, Vietnam

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER (NSCLC)