Global trial tests promising new combo against advanced lung cancer

NCT ID NCT05687266

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, global study is comparing a new three-drug combination to the current standard treatment for adults with advanced non-small cell lung cancer (NSCLC) that has spread and lacks certain genetic markers. The goal is to see if the new combination, which includes an experimental drug called Dato-DXd, can help patients live longer or keep the cancer from growing better than the standard treatment. About 1,350 participants will be randomly assigned to receive one of the two treatment approaches.

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Contacts and locations

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Locations

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Phoenix, Arizona, 85054, United States
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Tucson, Arizona, 85704, United States
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Hot Springs, Arkansas, 71913, United States
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Little Rock, Arkansas, 72205, United States
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Springdale, Arkansas, 72762, United States
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Fountain Valley, California, 92708, United States
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Los Angeles, California, 90017, United States
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Orange, California, 92868, United States
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Boulder, Colorado, 80303, United States
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Fort Myers, Florida, 33901, United States
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Jacksonville, Florida, 32224, United States
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St. Petersburg, Florida, 33705, United States
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West Palm Beach, Florida, 33401, United States
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Hinsdale, Illinois, 60521, United States
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Fort Wayne, Indiana, 46845, United States
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Bettendorf, Iowa, 52722, United States
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Iowa City, Iowa, 52242, United States
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Waukee, Iowa, 50263, United States
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Baton Rouge, Louisiana, 70808, United States
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Covington, Louisiana, 70433, United States
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Duluth, Minnesota, 55805, United States
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Rochester, Minnesota, 55905, United States
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Hannibal, Missouri, 63401, United States
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Lincoln, Nebraska, 68506, United States
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Lincoln, Nebraska, 68516, United States
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Clifton Park, New York, 12065, United States
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Asheville, North Carolina, 28806, United States
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Canton, Ohio, 44710, United States
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Columbus, Ohio, 43219, United States
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Maumee, Ohio, 43537, United States
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Tulsa, Oklahoma, 74134, United States
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Portland, Oregon, 97239, United States
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Salem, Oregon, 97301, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19107, United States
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Philadelphia, Pennsylvania, 19111, United States
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York, Pennsylvania, 17403, United States
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Watertown, South Dakota, 57201, United States
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Memphis, Tennessee, 38120, United States
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Dallas, Texas, 75246, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77090, United States
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Irving, Texas, 75063, United States
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Fairfax, Virginia, 22031, United States
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Henrico, Virginia, 23229, United States
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Norfolk, Virginia, 23502, United States
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Renton, Washington, 98055, United States
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Spokane, Washington, 99202, United States
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Tacoma, Washington, 98405, United States
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Appleton, Wisconsin, 54911, United States
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La Crosse, Wisconsin, 54601, United States
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Graz, 8036, Austria
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Rankweil, 6830, Austria
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Vienna, 1090, Austria
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Vienna, 1210, Austria
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Blumenau, 89010-340, Brazil
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Florianópolis, 88034-000, Brazil
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Fortaleza, 60336-045, Brazil
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Londrina, 86015-520, Brazil
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Porto Alegre, 90035-903, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 01509-900, Brazil
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São Paulo, 09323-900, Brazil
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Taubaté, 12030-200, Brazil
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Vitória, 29043-260, Brazil
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Sofia, 1113, Bulgaria
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Sofia, 1330, Bulgaria
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Varna, 9010, Bulgaria
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Saint John, New Brunswick, E2L 4L2, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Greater Sudbury, Ontario, P3E 5J1, Canada
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Kitchener, Ontario, N2G 1G3, Canada
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Newmarket, Ontario, L3Y 2P9, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Saint-Jérôme, Quebec, J7Z 5T3, Canada
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Saskatoon, Saskatchewan, S7N 4H4, Canada
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Beijing, 100010, China
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Beijing, 100029, China
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Beijing, 100037, China
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Beijing, 100039, China
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Beijing, 100853, China
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Beijing, CN-100730, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chongqing, 400037, China
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Guangzhou, 510000, China
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Guangzhou, 510100, China
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Hefei, 230601, China
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Jinan, 250021, China
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Kunming, 650101, China
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Lanzhou, 730000, China
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Liuchow, 545006, China
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Shandong, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Shanghai, 200080, China
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Shantou, 515041, China
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Shenyang, 110004, China
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Shenzhen, 517108, China
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Taiyuan, 030000, China
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Tianjin, 300060, China
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Wenzhou, 325000, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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Xiamen, 361004, China
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Yangzhou, 225001, China
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Zhengzhou, 450052, China
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Brest, 29200, France
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Créteil, 94010, France
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Gleizé, 69400, France
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Montpellier, 34070, France
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Nîmes, 30029, France
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Paris, 75018, France
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Paris, 75674, France
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Rouen, 76031, France
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Saint-Quentin, 02321, France
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Strasbourg, 67091, France
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Toulon, 83800, France
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Toulouse, 31059, France
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Tours, 37000, France
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Bad Berka, 99437, Germany
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Berlin, 14109, Germany
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Frankfurt A. Main, 60590, Germany
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Gauting, 82131, Germany
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Gütersloh, 33332, Germany
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Hamburg, 20251, Germany
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Kassel, 34125, Germany
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Kiel, 24116, Germany
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Koblenz, 56073, Germany
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Minden, 32429, Germany
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Rosenheim, 83022, Germany
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Velbert, 42551, Germany
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Würzburg, 97074, Germany
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Athens, 11526, Greece
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Athens, 11527, Greece
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Athens, 155 62, Greece
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Piraeus, 185 47, Greece
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Thessaloniki, 55236, Greece
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Thessaloniki, 57001, Greece
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Budapest, 1121, Hungary
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Budapest, 1122, Hungary
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Gyöngyös - Mátraháza, 3200, Hungary
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Kaposvár, 7400, Hungary
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Pécs, 7624, Hungary
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Szekszárd, 7100, Hungary
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Szolnok, 5000, Hungary
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Törökbálint, 2045, Hungary
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Calicut, 673601, India
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Delhi, 110029, India
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Delhi, 110085, India
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Jaipur, 302017, India
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Kolkata, 700160, India
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Madurai, 625107, India
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Puducherry, 605006, India
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Florence, 50134, Italy
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Lecco, 23900, Italy
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Messina, 98158, Italy
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Naples, 80131, Italy
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Orbassano, 10043, Italy
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Padua, 35128, Italy
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Parma, 43126, Italy
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Peschiera del Garda, 37019, Italy
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Rozzano, 20089, Italy
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Bunkyō City, 113-8603, Japan
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Chūōku, 104-0045, Japan
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Hamamatsu, 431-3192, Japan
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Hamamatsu, 432-8580, Japan
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Hidaka-shi, 350-1298, Japan
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Hirosaki-shi, 036-8563, Japan
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Hiroshima, 730-8518, Japan
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Kumamoto, 860-8556, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 466-8560, Japan
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Okayama, 700-8558, Japan
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Osaka, 545-8586, Japan
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Osakasayama-shi, 589-8511, Japan
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Sapporo, 060-8638, Japan
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Sunto-gun, 411-8777, Japan
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Wakayama, 641-8510, Japan
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Yokohama, 221-0855, Japan
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Yokohama, 241-8515, Japan
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Del. Cuauhtemoc, 06700, Mexico
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Mexico City, 03810, Mexico
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México, 14080, Mexico
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San Luis Potosí City, 78209, Mexico
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Arequipa, 04002, Peru
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Concepción, 12125, Peru
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Lima, 15036, Peru
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Lima, 34, Peru
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Lima, LIMA 27, Peru
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Lima, LIMA 29, Peru
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Bydgoszcz, 85-796, Poland
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Bystra, 43-360, Poland
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Grudziądz, 86-300, Poland
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Kielce, 25-734, Poland
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Koszalin, 75-581, Poland
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Olsztyn, 10-357, Poland
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Poznan, 60-569, Poland
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Przemyśl, 37-700, Poland
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Racibórz, 47-400, Poland
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Radom, 26-600, Poland
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Siedlce, 08-110, Poland
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Busan, 48108, South Korea
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Cheongju-si, 28644, South Korea
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Jinju, 52727, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 07061, South Korea
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Suwon, 16247, South Korea
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Suwon, 16499, South Korea
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Las Palmas de Gran Canaria, 35016, Spain
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Lugo, 27003, Spain
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Madrid, 28041, Spain
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Santander, 39008, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Zaragoza, 50009, Spain
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Gävle, 801 88, Sweden
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Linköping, 581 85, Sweden
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Lund, 221 85, Sweden
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Stockholm, 17176, Sweden
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Uppsala, 751 85, Sweden
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Hsinchu, 300, Taiwan
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New Taipei City, 235, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 73657, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan District, 333, Taiwan
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Adana, 01060, Turkey (Türkiye)
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Ankara, 06800, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Izmir, 35110, Turkey (Türkiye)
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Aberdeen, AB25 2ZN, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Cardiff, CF14 2TL, United Kingdom
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Cheltenham, GL53 7AN, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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London, SE1 9RT, United Kingdom
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London, W6 8RF, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Middlesbrough, TS4 3BW, United Kingdom
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Newcastle upon Tyne, NE7 7DN, United Kingdom
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Taunton, TA1 5DA, United Kingdom
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam

Conditions

Explore the condition pages connected to this study.

NSCLC