First human test of new leukemia pill seeks safe dose
NCT ID NCT04609826
Summary
This was the first study in people to test the safety of a new oral drug called JNJ-74856665 for advanced blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The main goal was to find the highest dose patients could tolerate without severe side effects, both when the drug was given alone and when combined with other standard cancer medications. The study involved 153 adults whose cancer had returned or did not respond to other treatments.
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Contacts and locations
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Locations
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Asan Medical Center
Seoul, 05505, South Korea
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CHRU Tours Hopital Bretonneau
Tours, 37000, France
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CHU de Nice Hopital de l Archet
Nice, 06200, France
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Centre Hospitalier Universitaire (CHU) de Bordeaux Hopital HautLeveque Centre Francois Magendie
Pessac, 33600, France
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Clinica Univ. de Navarra
Pamplona, 31008, Spain
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Hopital Saint Louis
Paris, 75010, France
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Hosp Clinic de Barcelona
Barcelona, 08036, Spain
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Hosp Univ Fund Jimenez Diaz
Madrid, 28040, Spain
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Hosp Univ Vall D Hebron
Barcelona, 08035, Spain
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Hosp. Univ. Marques de Valdecilla
Santander, 39008, Spain
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Inst. Cat. Doncologia-H Duran I Reynals
Barcelona, 08908, Spain
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Institut Universitaire du Cancer Toulouse Oncopole
Toulouse, 31059, France
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Kings College Hospital
London, SE5 9RF, United Kingdom
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Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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Samsung Medical Center
Seoul, 06351, South Korea
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Seoul National University Hospital
Seoul, 3080, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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The Catholic University of Korea Seoul St Marys Hospital
Seoul, 06591, South Korea
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The Christie Nhs Foundation Trust
Manchester, M20 4BX, United Kingdom
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University College London Hospitals
London, NW1 2BU, United Kingdom
Conditions
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