Simpler HIV pill? trial tests switch to new Two-Drug combo

NCT ID NCT05631093

Ongoing Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing if people with HIV who are already successfully controlling their virus can safely switch to a new, simpler two-drug pill (doravirine/islatravir) taken once daily. It compares this new pill to people continuing their current HIV medications to see if it works just as well at keeping the virus suppressed. The main goal is to see if the new pill is as effective and safe as standard therapy over 48 weeks.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Be Part Yoluntu Centre ( Site 3901)

Paarl, Western Cape, 7646, South Africa
Brighton and Sussex University Hospitals NHS Trust ( Site 4104)

East Sussex, Brighton And Hove, BN2 1ES, United Kingdom
CAN Community Health - Sarasota ( Site 3017)

Sarasota, Florida, 34237, United States
CHUV (centre hospitalier universitaire vaudois) ( Site 4006)

Lausanne, Canton of Vaud, 1011, Switzerland
Center Hospital of the National Center for Global Health and Medicine ( Site 4401)

Shinjyuku-ku, Tokyo, 162-8655, Japan
Central Texas Clinical Research ( Site 3015)

Austin, Texas, 78705, United States
Chatham County Health Department - Chatham CARE Center-Infectious Disease ( Site 3028)

Savannah, Georgia, 31401, United States
Ciensalud Ips S A S ( Site 3300)

Barranquilla, Atlántico, 08001, Colombia
Clinica de la Costa S.A.S. ( Site 3305)

Barranquilla, Atlántico, 080020, Colombia
Clinique Medicale lActuel-Clinical Research ( Site 3100)

Montreal, Quebec, H2L 4P9, Canada
Clinique de médecine Urbaine du Quartier Latin ( Site 3101)

Montreal, Quebec, H2L 4E9, Canada
DCOL Center for Clinical Research ( Site 3022)

Longview, Texas, 75605, United States
Desmond Tutu Health Foundation ( Site 3902)

Cape Town, Western Cape, 7925, South Africa
Ezintsha-Clinical Research Site ( Site 3907)

Johannesburg, Gauteng, 2193, South Africa
Family Clinical Research Unit (Fam-Cru)-Adult Infectious Diseases ( Site 3908)

Cape Town, Western Cape, 7505, South Africa
Fundacion Valle del Lili- CIC ( Site 3302)

Cali, Valle del Cauca Department, 760032, Colombia
Georgetown University Medical Center ( Site 3006)

Washington D.C., District of Columbia, 20007, United States
Hamilton Health Sciences- Urgent Care Centre-SIS Clinic ( Site 3104)

Hamilton, Ontario, L8S 1A4, Canada
Heartlands Hospital ( Site 4102)

Birmingham, B9 5SS, United Kingdom
Helen Joseph Hospital ( Site 3910)

Johannesburg, Gauteng, 2092, South Africa
Holdsworth House Medical Practice ( Site 4200)

Darlinghurst, New South Wales, 2010, Australia
Holdsworth House Medical Practice - Brisbane ( Site 4201)

Brisbane, Queensland, 4006, Australia
Hôpitaux Universitaires de Genève (HUG)-Infectious Disease Department ( Site 4004)

Geneva, Canton of Geneva, 1211, Switzerland
ID Care ( Site 3041)

Hillsborough, New Jersey, 08844, United States
Infectious Disease Specialists of Atlanta ( Site 3003)

Decatur, Georgia, 30033, United States
Inselspital Bern-Inselspital Infektiologie ( Site 4003)

Bern, 3010, Switzerland
Josha Research ( Site 3903)

Bloemfontein, Free State, 9300, South Africa
Kaiser Permanente-Infectious Disease ( Site 3014)

Los Angeles, California, 90027, United States
King's College Hospital ( Site 4108)

London, London, City of, SE5 9RL, United Kingdom
Maple Leaf Research ( Site 3103)

Toronto, Ontario, M5G 1K2, Canada
Midway Immunology and Research Center ( Site 3009)

Ft. Pierce, Florida, 34982, United States
National Hospital Organization Nagoya Medical Center ( Site 4403)

Nagoya, Aichi-ken, 460-0001, Japan
North Manchester General Hospital ( Site 4107)

Crumpsall, England, M8 5RB, United Kingdom
Orlando Immunology Center ( Site 3004)

Orlando, Florida, 32803, United States
Ospedale Regionale di Lugano, Sede Civico-Servizio Malattie Infettive ( Site 4005)

Lugano, Canton Ticino, 6903, Switzerland
Palmtree Clinical Research ( Site 3032)

Palm Springs, California, 92262, United States
Penn Medicine: University of Pennsylvania Health System-Perelman Center for Advanced Medicine ( Site

Philadelphia, Pennsylvania, 19104, United States
Perinatal HIV Research Unit (PHRU)-Adult Treatment and Research ( Site 3905)

Johannesburg, Gauteng, 2013, South Africa
Prahran Market Clinic ( Site 4202)

Melbourne, Victoria, 3181, Australia
Private Practice Dr. Marleen de Jager ( Site 3900)

Pretoria, Gauteng, 0007, South Africa
Royal Brisbane and Women's Hospital-Infectious Diseases Research ( Site 4204)

Brisbane, Queensland, 4029, Australia
Royal Free Hospital ( Site 4101)

London, England, NW32QG, United Kingdom
Royal London Hospital ( Site 4100)

London, England, E1 1BB, United Kingdom
Royal Victoria Infirmary ( Site 4105)

Newcastle upon Tyne, England, NE1 4LP, United Kingdom
St Vincent's Hospital-IBAC ( Site 4203)

Sydney, New South Wales, 2010, Australia
The Crofoot Research Center ( Site 3040)

Houston, Texas, 77098, United States
Tokyo Medical University Hospital ( Site 4404)

Shinjuku-ku, Tokyo, 160-0023, Japan
Toronto General Hospital ( Site 3102)

Toronto, Ontario, M5G 2M1, Canada
Triple O Research Institute, P.A ( Site 3026)

West Palm Beach, Florida, 33407, United States
University Hospital Basel-Infectiology ( Site 4002)

Basel, Canton of Basel-City, 4031, Switzerland
UniversitätsSpital Zürich ( Site 4000)

Zurich, Canton of Zurich, 8091, Switzerland
Wentworth Hospital ( Site 3904)

Durban, KwaZulu-Natal, 4052, South Africa
Zuckerberg San Francisco General Hospital and Trauma Center-UCSF ID Clinical Trials Center ( Site 30

San Francisco, California, 94110, United States

Conditions

Explore the condition pages connected to this study.

HIV-1-INFECTION