Brain cancer breakthrough? new drug shows promise in Mid-Stage trial

NCT ID NCT04250922

First seen Nov 20, 2025 · Last updated Apr 19, 2026 · Updated 22 times

Summary

This trial is testing if adding an experimental drug called LAM561 to the standard treatment for a fast-growing brain cancer (glioblastoma) can help control the disease better. It involves 144 newly diagnosed adult patients who will receive either LAM561 or a placebo pill along with their standard radiation and chemotherapy. The main goal is to see if the drug combination can delay cancer growth and help patients live longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cambridge university hospital

    Cambridge, United Kingdom

  • Centre Eugène Marquis (CEM)

    Rennes, France

  • Freeman Hospital's Northern Centre of Cancer Care

    Newcastle, Newcastle Upon Tyne, NE7 7DN, United Kingdom

  • Gustave Roussy University Hospital

    Rennes, France

  • Hospital Clinic

    Barcelona, Barcelona, Spain

  • Hospital Clínico San Carlos

    Madrid, Madrid, Spain

  • Hospital Parc Tauli

    Sabadell, Spain

  • Hospital Universitari i Politécnic La Fe.

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario 12 De Octubre

    Madrid, Spain

  • Hospital Universitario Reina Sofía

    Córdoba, Andalusia, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, Andalusia, Spain

  • Hospital Vall d'Hebron

    Barcelona, Barcelona, Spain

  • Hospital del Mar

    Barcelona, Spain

  • Institut Cancerologie de L'Ouest (ICO)

    Angers, France

  • Institut universitaire du cancer

    Toulouse, France

  • Istituto Nazionale Neurologico Carlo Besta

    Milan, Italy

  • Istituto Nazionale Tumori "Regina Elena"

    Roma, Italy

  • Istituto Oncologico Veneto IRCCS

    Padova, Veneto, 35131, Italy

  • Reaserch Fund of the Hadassah Medical Organization

    Jerusalem, Israel

  • The Royal Marsden Hospital

    London, United Kingdom

  • University Hospitals Birmingham NHS Foundation Trust - New Queen Elizabeth Hospital

    Birmingham, United Kingdom

  • University of Turin

    Turin, Italy

Conditions

Explore the condition pages connected to this study.