Major trial tests promising new combo for Tough-to-Treat uterine cancer

NCT ID NCT04269200

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding two newer drugs, durvalumab and olaparib, to standard chemotherapy helps women with advanced or recurrent endometrial cancer live longer without their cancer getting worse. It involves about 805 women who have not yet received treatment for their advanced disease. The goal is to see if this combination can better control the cancer compared to chemotherapy alone.

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Locations

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Tucson, Arizona, 85719, United States
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Concord, California, 94520-2278, United States
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La Jolla, California, 92093, United States
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San Francisco, California, 94158, United States
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Santa Barbara, California, 93105, United States
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Aurora, Colorado, 80012, United States
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Fort Lauderdale, Florida, 33316, United States
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Tampa, Florida, 33612, United States
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Savannah, Georgia, 31404, United States
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Honolulu, Hawaii, 96826, United States
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Arlington Heights, Illinois, 60005, United States
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Chicago, Illinois, 60637, United States
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Indianapolis, Indiana, 46237, United States
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Louisville, Kentucky, 40207, United States
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Baton Rouge, Louisiana, 70817, United States
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Boston, Massachusetts, 02111, United States
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Saint Paul, Minnesota, 55125, United States
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Jackson, Mississippi, 39216, United States
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Lebanon, New Hampshire, 03756, United States
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Camden, New Jersey, 08103, United States
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Paramus, New Jersey, 07652, United States
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New York, New York, 10011, United States
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New York, New York, 10029, United States
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Pinehurst, North Carolina, 28374, United States
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Cleveland, Ohio, 44109, United States
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Cleveland, Ohio, 44124, United States
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Dayton, Ohio, 45459, United States
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Oklahoma City, Oklahoma, 73104, United States
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Tulsa, Oklahoma, 74134, United States
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Eugene, Oregon, 97401, United States
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Tigard, Oregon, 97223, United States
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Pittsburgh, Pennsylvania, 15224, United States
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Providence, Rhode Island, 02905, United States
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Sioux Falls, South Dakota, 57105, United States
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Chattanooga, Tennessee, 37403, United States
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Germantown, Tennessee, 38138, United States
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Knoxville, Tennessee, 37920, United States
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Bedford, Texas, 76022, United States
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Dallas, Texas, 75231, United States
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Houston, Texas, 77030, United States
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San Antonio, Texas, 78240, United States
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Sugar Land, Texas, 77479, United States
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Tyler, Texas, 75702, United States
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Webster, Texas, 77598, United States
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Fairfax, Virginia, 22031, United States
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Norfolk, Virginia, 23502, United States
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Seattle, Washington, 98195, United States
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Morgantown, West Virginia, 26505, United States
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Madison, Wisconsin, 53792, United States
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Milwaukee, Wisconsin, 53226, United States
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Clayton, 3168, Australia
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Malvern, 3144, Australia
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Melbourne, 3000, Australia
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Nedlands, 6009, Australia
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Sydney, NSW 2145, Australia
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Bruges, 8000, Belgium
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Brussels, 1200, Belgium
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Charleroi, 6000, Belgium
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Ghent, 9000, Belgium
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Hasselt, 3500, Belgium
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Kortrijk, 8500, Belgium
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Leuven, 3000, Belgium
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Libramont-Chevigny, 6800, Belgium
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Liège, 4000, Belgium
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Belo Horizonte, 30130-090, Brazil
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Belo Horizonte, 30150-274, Brazil
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Curitiba, 80520-174, Brazil
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Passo Fundo, 99010-080, Brazil
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Pelotas, 96020-080, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90035-003, Brazil
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Porto Alegre, 90110-270, Brazil
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Rio de Janeiro, 20231-050, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01317-001, Brazil
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Calgary, Alberta, T2N 4N2, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H2L 4M1, Canada
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Montreal, Quebec, H3A 1A1, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Beijing, 100034, China
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Beijing, 100142, China
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Changchun, 130012, China
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Changchun, 130021, China
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Changsha, 410003, China
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Changsha, 410008, China
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Chengdu, 610041, China
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Chongqing, 400038, China
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Chongqing, 408099, China
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Dalian, 116001, China
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Dalian, 116027, China
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Guangdong, China
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Guangzhou, 510060, China
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Haikou, 570311, China
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Harbin, 150081, China
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Hefei, 230031, China
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Nanning, 530021, China
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Shanghai, 200032, China
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Shenyang, 110042, China
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Taiyuan, 030001, China
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Tianjin, 300060, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Zhanjiang, 524001, China
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Zhengzhou, 450008, China
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Zhengzhou, China
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Barranquilla, 80020, Colombia
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Bogotá, 110321, Colombia
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Bogotá, 111321, Colombia
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Bogotá, 111511, Colombia
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Cali, 760043, Colombia
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Medellín, 50025, Colombia
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Medellín, 50030, Colombia
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Montería, 23001, Colombia
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Pereira, 660001, Colombia
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Tallinn, 1131, Estonia
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Tartu, 50406, Estonia
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Bonn, 53127, Germany
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Chemnitz, 09116, Germany
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Dresden, 01307, Germany
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Erlangen, 91054, Germany
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Leipzig, 4103, Germany
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Athens, 11528, Greece
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Chaïdári, 124 62, Greece
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Thessaloniki, 54645, Greece
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Hong Kong, Hong Kong
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Budapest, 1062, Hungary
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Budapest, 1122, Hungary
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Budapest, 1145, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Szolnok, 5004, Hungary
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Hisar, 125005, India
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Mumbai, 400012, India
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Be’er Ya‘aqov, 70300, Israel
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Hadera, 3810101, Israel
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Jerusalem, 91031, Israel
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Nahariya, 22100, Israel
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Tel Aviv, 6423906, Israel
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Chūōku, 104-0045, Japan
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Kashiwa-shi, 277-8567, Japan
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Kōtoku, 135-8550, Japan
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Kurume-shi, 830-0011, Japan
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Kyoto, 606-8507, Japan
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Matsuyama, 791-0280, Japan
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Minatoku, 105-8471, Japan
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Nagoya, 464-8681, Japan
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Nakagami-gun, 903-0215, Japan
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Niigata, 951-8520, Japan
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Osaka, 541-8567, Japan
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Osaka, 637086, Japan
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Sapporo, 003-0804, Japan
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Shinjuku-ku, 160-8582, Japan
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Sunto-gun, 411-8777, Japan
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Toon-Shi, 791-0295, Japan
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Tsu, 514-8507, Japan
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Yokohama, 236-0004, Japan
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Kaunas, 50161, Lithuania
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Vilnius, 08661, Lithuania
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Vilnius, 8660, Lithuania
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Aguascalientes, 20116, Mexico
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México, 06700, Mexico
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Monterrey, 64000, Mexico
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Oaxaca City, 68000, Mexico
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Querétaro, 76090, Mexico
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San Luis Potosí City, 78200, Mexico
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Veracruz, 91910, Mexico
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Gdansk, 80-214, Poland
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Lodz, 93-513, Poland
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Lublin, 20-081, Poland
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Olsztyn, 10-228, Poland
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Olsztyn, 10-560, Poland
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Anzorey, 361350, Russia
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Kazan, Tatarstan, 420029, Russia
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Krasnodar, 350040, Russia
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Moscow, 115478, Russia
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Moscow, 117997, Russia
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Saint Petersburg, 198255, Russia
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Saransk, 430032, Russia
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Sochi, 354000, Russia
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Singapore, 119228, Singapore
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Singapore, 169610, Singapore
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Singapore, 258499, Singapore
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Goyang-si, 10408, South Korea
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Seoul, 01812, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 138-736, South Korea
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Suwon, 443380, South Korea
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Yangsan, 50612, South Korea
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Barcelona, 08208, Spain
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Barcelona, 08907, Spain
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El Palmar, 30120, Spain
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Girona, 17007, Spain
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Jaén, 23007, Spain
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Madrid, 28046, Spain
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Mallorca, 07120, Spain

Conditions

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ENDOMETRIAL NEOPLASMS