New hope for eczema sufferers: experimental drug GHZ339 enters Mid-Stage trial

NCT ID NCT06947993

Recruiting now Symptom relief Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial is testing an experimental drug called GHZ339 in 224 adults with moderate to severe atopic dermatitis (eczema). Participants will receive either the drug or a placebo, and researchers will measure changes in eczema severity using the EASI score at 16 weeks. The goal is to see if GHZ339 can safely reduce skin inflammation and improve symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

GHZ339

What this could lead to

If successful, this could lead to a new treatment option that reduces eczema severity and improves quality of life for people with moderate to severe atopic dermatitis.

What could go wrong

This is an early Phase 2 trial with a small number of participants, so results may not confirm effectiveness. The drug may cause side effects or fail to outperform placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

atopic eczema dermatitis Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS

Contacts and locations

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Study contacts

Contact

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Locations

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Birmingham, Alabama, 35233, United States
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Birmingham, Alabama, 35244, United States
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Fort Smith, Arkansas, 72916, United States
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Fountain Valley, California, 92708, United States
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Los Angeles, California, 90056, United States
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Sacramento, California, 95815, United States
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Santa Ana, California, 92701, United States
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Santa Monica, California, 90404, United States
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Washington D.C., District of Columbia, 20060, United States
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Miami, Florida, 33144, United States
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Atlanta, Georgia, 30342, United States
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Macon, Georgia, 31217, United States
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Louisville, Kentucky, 40241, United States
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Brighton, Massachusetts, 02135, United States
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Troy, Michigan, 48084, United States
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Saint Joseph, Missouri, 64506, United States
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Brooklyn, New York, 11203, United States
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Arlington, Texas, 76011, United States
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Cypress, Texas, 77433, United States
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Dallas, Texas, 75235-9069, United States
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Houston, Texas, 77030, United States
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San Antonio, Texas, 78218, United States
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Caba, Buenos Aires, C1119ACN, Argentina
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Caba, Buenos Aires, C1121ABE, Argentina
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Rosario, Santa Fe Province, S2000DBS, Argentina
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Edmonton, Alberta, T5K 1X3, Canada
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Hamilton, Ontario, L8L 3C3, Canada
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Markham, Ontario, L3P 1X3, Canada
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Montreal, Quebec, H1Y 3L1, Canada
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Verdun, Quebec, H4G 3E7, Canada
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Guangzhou, Guangdong, 510091, China
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Shantou, Guangdong, 515000, China
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Changsha, Hunan, 410008, China
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Changchun, Jilin, 130021, China
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Hangzhou, Zhejiang, 310001, China
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Beijing, 100029, China
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Beijing, 100050, China
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Shanghai, 200040, China
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Plzen Bory, 301 00, Czechia
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Prague, 100 34, Czechia
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Prague, 130 00, Czechia
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Prague, 150 06, Czechia
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Brest, 29609, France
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Lille, 59037, France
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Lorient, 56322, France
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Paris, 75475, France
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Pierre-Bénite, 69495, France
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Reims, 51100, France
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Rouen, 76031, France
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Frankfurt am Main, Hesse, 60590, Germany
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Mainz, Rhineland-Palatinate, 55128, Germany
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Bad Bentheim, 48455, Germany
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Dresden, 01097, Germany
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Hamburg, 20246, Germany
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Heidelberg, 69120, Germany
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Magdeburg, 39120, Germany
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Münster, 48149, Germany
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Oldenburg, 26133, Germany
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Pécs, Baranya, 7623, Hungary
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Budapest, 1033, Hungary
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Budapest, H-1083, Hungary
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Szeged, 6725, Hungary
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Ancona, AN, 60126, Italy
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Cona, FE, 44124, Italy
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Nagoya, Aichi-ken, 4678602, Japan
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Matsudo, Chiba, 2710092, Japan
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Kawasaki, Kanagawa, 211-0063, Japan
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Yokohama, Kanagawa, 220-6208, Japan
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Habikino, Osaka, 583 8588, Japan
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Shinagawa Ku, Tokyo, 141 8625, Japan
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Fukuoka, 8128582, Japan
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Kyoto, 6078062, Japan
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Rotterdam, South Holland, 3015 GD, Netherlands
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Utrecht, 3584 CX, Netherlands
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Warsaw, Masovian Voivodeship, 02-953, Poland
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Katowice, 40-611, Poland
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Lodz, 90-436, Poland
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Lublin, 20-573, Poland
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Warsaw, 02-962, Poland
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Bardejov, 085 01, Slovakia
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Komárno, 945 01, Slovakia
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Košice, 040 22, Slovakia
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Košice, 041 90, Slovakia
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Prešov, 080 01, Slovakia
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Ansan, Gyeonggi-do, 425-801, South Korea
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Seoul, 03722, South Korea
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Badalona, Barcelona, 08916, Spain
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Alicante, 03010, Spain
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Granada, 18016, Spain
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Las Palmas GC, 35010, Spain
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Madrid, 28006, Spain
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Madrid, 28041, Spain
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Pontevedra, 36003, Spain
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Kaohsiung City, 83301, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Dudley, West Midlands, DY1 2HQ, United Kingdom
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Liverpool, L7 8XP, United Kingdom