Head-to-Head trial tests promising new drug combo for rare blood cancer

NCT ID NCT04840602

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is comparing two different drug combination strategies for people newly diagnosed with a rare, slow-growing blood cancer called Waldenström's macroglobulinemia. About 92 participants will be randomly assigned to receive either a combination of ibrutinib and rituximab (or zanubrutinib alone) or a combination of venetoclax and rituximab. The main goal is to see which approach leads to a deeper and more lasting reduction of the cancer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Adena Regional Medical Center
SUSPENDED

Chillicothe, Ohio, 45601, United States
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States

Contact

Contact Email: •••••@•••••
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Cancer Hematology Centers - Flint
RECRUITING

Flint, Michigan, 48503, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Carolinas Medical Center/Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States

Contact

Contact Phone: •••-•••-••••
Central Ohio Breast and Endocrine Surgery
SUSPENDED

Gahanna, Ohio, 43230, United States
Centralia Oncology Clinic
RECRUITING

Centralia, Illinois, 62801, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Columbus Oncology and Hematology Associates Inc
SUSPENDED

Columbus, Ohio, 43214, United States
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Delaware Health Center-Grady Cancer Center
SUSPENDED

Delaware, Ohio, 43015, United States
Doctors Hospital
SUSPENDED

Columbus, Ohio, 43228, United States
Dublin Methodist Hospital
SUSPENDED

Dublin, Ohio, 43016, United States
Fairfield Medical Center
SUSPENDED

Lancaster, Ohio, 43130, United States
Genesee Hematology Oncology PC
SUSPENDED

Flint, Michigan, 48503, United States
Genesis Healthcare System Cancer Care Center
SUSPENDED

Zanesville, Ohio, 43701, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Glens Falls Hospital
ACTIVE_NOT_RECRUITING

Glens Falls, New York, 12801, United States
Grady Memorial Hospital
SUSPENDED

Delaware, Ohio, 43015, United States
Grant Medical Center
SUSPENDED

Columbus, Ohio, 43215, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hematology Oncology Consultants-Clarkston
RECRUITING

Clarkston, Michigan, 48346, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Henry Ford Macomb Hospital-Clinton Township
RECRUITING

Clinton Township, Michigan, 48038, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Henry Ford Medical Center-Columbus
RECRUITING

Novi, Michigan, 48377, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Henry Ford West Bloomfield Hospital
RECRUITING

West Bloomfield, Michigan, 48322, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Huron Gastroenterology PC
RECRUITING

Ypsilanti, Michigan, 48106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Knox Community Hospital
SUSPENDED

Mount Vernon, Ohio, 43050, United States
Levine Cancer Institute-Gaston
RECRUITING

Gastonia, North Carolina, 28054, United States

Contact

Contact Phone: •••-•••-••••
Licking Memorial Hospital
RECRUITING

Newark, Ohio, 43055, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Marietta Memorial Hospital
SUSPENDED

Marietta, Ohio, 45750, United States
Marshfield Medical Center - Minocqua
ACTIVE_NOT_RECRUITING

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston
ACTIVE_NOT_RECRUITING

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center
ACTIVE_NOT_RECRUITING

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield
ACTIVE_NOT_RECRUITING

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake
ACTIVE_NOT_RECRUITING

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point
ACTIVE_NOT_RECRUITING

Stevens Point, Wisconsin, 54482, United States
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States

Contact

Contact Phone: •••-•••-••••
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224-9980, United States

Contact

Contact Phone: •••-•••-••••
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

Contact

Contact Phone: •••-•••-••••
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States

Contact

Contact Phone: •••-•••-••••
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States

Contact

Contact Phone: •••-•••-••••
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

Contact

Contact Phone: •••-•••-••••
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States

Contact

Contact Phone: •••-•••-••••
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

Contact

Contact Phone: •••-•••-••••
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States

Contact

Contact Phone: •••-•••-••••
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States

Contact

Contact Phone: •••-•••-••••
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States

Contact

Contact Phone: •••-•••-••••
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States

Contact

Contact Phone: •••-•••-••••
Mercy Health - Perrysburg Hospital
SUSPENDED

Perrysburg, Ohio, 43551, United States
Mercy Health - Saint Anne Hospital
SUSPENDED

Toledo, Ohio, 43623, United States
Mercy Health - Saint Vincent Hospital
SUSPENDED

Toledo, Ohio, 43608, United States
Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Michigan Healthcare Professionals Pontiac
RECRUITING

Pontiac, Michigan, 48341, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Mount Carmel East Hospital
SUSPENDED

Columbus, Ohio, 43213, United States
Mount Carmel Grove City Hospital
SUSPENDED

Grove City, Ohio, 43123, United States
Mount Carmel Health Center West
SUSPENDED

Columbus, Ohio, 43222, United States
MyMichigan Medical Center Saginaw
RECRUITING

Saginaw, Michigan, 48601, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
MyMichigan Medical Center Tawas
RECRUITING

Tawas City, Michigan, 48764, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
Newark Radiation Oncology
SUSPENDED

Newark, Ohio, 43055, United States
Newland Medical Associates-Clarkston
RECRUITING

Clarkston, Michigan, 48346, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Newland Medical Associates-Pontiac
RECRUITING

Pontiac, Michigan, 48341, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
OhioHealth Mansfield Hospital
SUSPENDED

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital
SUSPENDED

Marion, Ohio, 43302, United States
Oncology Hematology Associates of Saginaw Valley PC
SUSPENDED

Saginaw, Michigan, 48604, United States
Providence Cancer Institute Clackamas Clinic
SUSPENDED

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Riverside Methodist Hospital
SUSPENDED

Columbus, Ohio, 43214, United States
Saint Ann's Hospital
SUSPENDED

Westerville, Ohio, 43081, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Rita's Medical Center
SUSPENDED

Lima, Ohio, 45801, United States
Saint Vincent Frontier Cancer Center
RECRUITING

Billings, Montana, 59102, United States

Contact

Contact Phone: •••-•••-••••
Siteman Cancer Center at Christian Hospital
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63136, United States
Siteman Cancer Center at Saint Peters Hospital
ACTIVE_NOT_RECRUITING

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital
ACTIVE_NOT_RECRUITING

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63129, United States
Southeastern Medical Oncology Center-Clinton
RECRUITING

Clinton, North Carolina, 28328, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Southeastern Medical Oncology Center-Goldsboro
RECRUITING

Goldsboro, North Carolina, 27534, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Southeastern Medical Oncology Center-Jacksonville
RECRUITING

Jacksonville, North Carolina, 28546, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States

Contact

Contact Phone: •••-•••-••••
Southern Ohio Medical Center
SUSPENDED

Portsmouth, Ohio, 45662, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States

Contact

Contact Phone: •••-•••-••••
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Strecker Cancer Center-Belpre
SUSPENDED

Belpre, Ohio, 45714, United States
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Mark H Zangmeister Center
SUSPENDED

Columbus, Ohio, 43219, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States

Contact

Contact Phone: •••-•••-••••
UM Sylvester Comprehensive Cancer Center at Coral Springs
RECRUITING

Coral Springs, Florida, 33065, United States

Contact

Contact Phone: •••-•••-••••
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

Contact

Contact Phone: •••-•••-••••
UM Sylvester Comprehensive Cancer Center at Doral
RECRUITING

Doral, Florida, 33166, United States

Contact

Contact Email: •••••@•••••
UM Sylvester Comprehensive Cancer Center at Hollywood
RECRUITING

Hollywood, Florida, 33021, United States

Contact

Contact Phone: •••-•••-••••
UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States

Contact

Contact Phone: •••-•••-••••
UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States

Contact

Contact Phone: •••-•••-••••
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States

Contact

Contact Email: •••••@•••••
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

Contact

Contact Phone: •••-•••-••••
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
RECRUITING

North Miami, Florida, 33181, United States

Contact

Contact Email: •••••@•••••
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of Rochester
RECRUITING

Rochester, New York, 14642, United States

Contact

Contact Phone: •••-•••-••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Washington University School of Medicine
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

LYMPHOPLASMACYTIC LYMPHOMA WALDENSTROM MACROGLOBULINEMIA