Hope for lymphoma patients: new drug cocktail targets resistant cancer

NCT ID NCT05890352

Recruiting now Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding either tazemetostat or zanubrutinib to a standard two-drug therapy (tafasitamab and lenalidomide) can shrink tumors or delay cancer return in people with large B-cell lymphoma that came back or didn't respond to prior treatment. About 227 adults who are not eligible for a stem cell transplant will participate. The goal is to find better treatment options for this hard-to-treat cancer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement non-Hodgkin lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRADE 3B FOLLICULAR LYMPHOMA HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 AND/OR BCL6 REARRANGEMENTS HIGH-GRADE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA TRANSFORMED NON-HODGKIN LYMPHOMA

Contacts and locations

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Locations

Aurora Bay Area Medical Group-Marinette
RECRUITING

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center
RECRUITING

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton
RECRUITING

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South
RECRUITING

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee
RECRUITING

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West
RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine
RECRUITING

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC
RECRUITING

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center
RECRUITING

Germantown, Wisconsin, 53022, United States
Aurora Medical Center in Summit
RECRUITING

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Aurora Sinai Medical Center
RECRUITING

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center
RECRUITING

West Allis, Wisconsin, 53227, United States
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Ben Taub General Hospital
RECRUITING

Houston, Texas, 77030, United States
Cancer Hematology Centers - Flint
RECRUITING

Flint, Michigan, 48503, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
City of Hope Antelope Valley
RECRUITING

Lancaster, California, 93534, United States

Contact Email: •••••@•••••
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
City of Hope Newport Beach
RECRUITING

Newport Beach, California, 92660, United States
City of Hope Seacliff
RECRUITING

Huntington Beach, California, 92648, United States
City of Hope South Bay
RECRUITING

Torrance, California, 90503, United States
City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States

Contact Email: •••••@•••••
City of Hope Upland
RECRUITING

Upland, California, 91786, United States

Contact Email: •••••@•••••
City of Hope at Long Beach Elm
RECRUITING

Long Beach, California, 90813, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Genesee Hematology Oncology PC
SUSPENDED

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
Holy Cross Hospital
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States
Huron Gastroenterology PC
RECRUITING

Ypsilanti, Michigan, 48106, United States
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

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Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

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Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States

Contact Email: •••••@•••••
Mount Sinai Medical Center
SUSPENDED

Miami Beach, Florida, 33140, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Northwest Cancer Center - Hobart
RECRUITING

Hobart, Indiana, 46342, United States
Northwest Cancer Center - Main Campus
RECRUITING

Crown Point, Indiana, 46307, United States
Northwest Cancer Center - Valparaiso
RECRUITING

Valparaiso, Indiana, 46383, United States

Contact Email: •••••@•••••
Northwest Oncology LLC
RECRUITING

Dyer, Indiana, 46311, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

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Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

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Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact Email: •••••@•••••
Saint Catherine Hospital
RECRUITING

Indianapolis, Indiana, 46312, United States
Saint Mary Medical Center
RECRUITING

Hobart, Indiana, 46342, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
The Community Hospital
RECRUITING

Munster, Indiana, 46321, United States
ThedaCare Regional Cancer Center
RECRUITING

Appleton, Wisconsin, 54911, United States

Contact Email: •••••@•••••
Tower Cancer Research Foundation
RECRUITING

Beverly Hills, California, 90211, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UC Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States

Contact Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Ankeny Clinic
SUSPENDED

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
SUSPENDED

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
SUSPENDED

Clive, Iowa, 50325, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

Contact Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact Email: •••••@•••••
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vince Lombardi Cancer Clinic - Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers
RECRUITING

Two Rivers, Wisconsin, 54241, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

Contact Email: •••••@•••••
Women's Diagnostic Center - Munster
RECRUITING

Munster, Indiana, 46321, United States

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