Early trial tests novel drug combo for tough blood cancers
NCT ID NCT05275439
Summary
This early-stage study aimed to test the safety and initial effectiveness of a new drug called SL-172154. It was given alone or combined with standard drugs (azacitidine and/or venetoclax) to adults with higher-risk forms of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). The main goal was to find a safe dose and see how the body processes the drug, while also checking for early signs that it might help control the cancer.
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Contacts and locations
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Locations
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Baylor Scott & White Research Institute
Dallas, Texas, 75246, United States
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City of Hope
Duarte, California, 91010, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Imperial College Healthcare NHS Trust
London, W12 0HS, United Kingdom
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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King's College Hospital NHS Foundation Trust
London, Denmark Hill, SE5 9RS, United Kingdom
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Norton Cancer Institute
Louisville, Kentucky, 40202, United States
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2C1, Canada
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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START Midwest
Grand Rapids, Michigan, 49546, United States
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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The University of Chicago
Chicago, Illinois, 60637, United States
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Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2, Canada
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UCLA Medical Center-Bowyer Oncology Center
Los Angeles, California, 90095, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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University Hospitals Plymouth NHS Trust, Derriford Hospital
Crownhill, Plymouth, PL6 8DH, United Kingdom
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University of Cincinnati Medical Center
Cincinnati, Ohio, 45219, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of North Carolina, Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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VCU Massey Cancer Center
Richmond, Virginia, 23219, United States
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Yale Cancer Center
New Haven, Connecticut, 06510, United States
Conditions
Explore the condition pages connected to this study.