New hope for stomach cancer: experimental combo enters final trial phase

NCT ID NCT07118527

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether a new combination of drugs (SHR-A1811, adebrelimab, and chemotherapy) works better than the current standard treatment for people with advanced stomach or gastroesophageal junction cancer that has not been treated before. The study will enroll about 600 participants and measure how long they live without their cancer getting worse, as well as overall survival. The goal is to find a more effective first-line therapy for this aggressive cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

SHR-A1811 (a targeted drug) combined with adebrelimab (immunotherapy) and chemotherapy (capecitabine or fluorouracil)

What this could lead to

If successful, this could offer a new first-line treatment option for advanced stomach cancer, potentially improving how long patients live without their cancer growing.

What could go wrong

This is an early-stage phase 3 trial, so results are not yet known. The new combination may not be more effective than current standard therapy and could have unexpected side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

gastric adenocarcinoma gastroesophageal adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The First Hospital of China Medical University

    RECRUITING

    Shenyang, Liaoning, 110001, China

    Contact

  • Zhongshan Hospital,Fudan University

    RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

    Contact