New hope for stomach cancer: targeted combo enters phase 2 trial

NCT ID NCT06628310

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 27 times

Summary

This study tests a new drug combination (telisotuzumab adizutecan, budigalimab, and two standard chemotherapies) as a first treatment for adults with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery. About 180 participants will receive either the new combo or standard chemo to see which works better and is safer. The goal is to slow cancer growth and improve response rates.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AdventHealth Orlando /ID# 268561
RECRUITING

Orlando, Florida, 32803, United States
Aichi Cancer Center /ID# 268124
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Algemeen Ziekenhuis klina /ID# 268754
RECRUITING

Brasschaat, Antwerpen, 2930, Belgium
Barts Health NHS Trust /ID# 270796
RECRUITING

London, Greater London, E1 2ES, United Kingdom
Beijing Cancer Hospital /ID# 268455
RECRUITING

Beijing, Beijing Municipality, 100142, China
CHU de Liege /ID# 270223
RECRUITING

Liège, 4000, Belgium
Cancer Hospital Chinese Academy of Medical Sciences(Langfang) /ID# 277479
RECRUITING

Langfang, Hebei, 065000, China
Centre Hospitalier de l'Universite de Montreal (CHUM) /ID# 268763
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
China Medical University Hospital /ID# 267667
RECRUITING

Taichung, 40447, Taiwan
City Of Hope - Atlanta. /ID# 280646
RECRUITING

Newnan, Georgia, 30265, United States
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 272630
RECRUITING

Irvine, California, 92618, United States
City of Hope National Medical Center /ID# 268690
RECRUITING

Duarte, California, 91010, United States
Complexo Hospitalario Universitario de Ourense /ID# 270042
RECRUITING

Ourense, 32005, Spain
Duke University Medical Center /ID# 268186
RECRUITING

Durham, North Carolina, 27710, United States
Hadassah Medical Center-Hebrew University /ID# 267753
RECRUITING

Jerusalem, 91120, Israel
Haematologisch-Onkologische Praxis Eppendorf /ID# 268024
RECRUITING

Hamburg, 20249, Germany
Harbin Medical University Cancer Hospital /ID# 268452
RECRUITING

Harbin, Heilongjiang, 150081, China
Hattiesburg Clinic /ID# 268572
RECRUITING

Hattiesburg, Mississippi, 39401, United States
Hospital Clinico Universitario de Valencia /ID# 270040
RECRUITING

Valencia, 46010, Spain
Hospital General Universitario Gregorio Maranon /ID# 270037
RECRUITING

Madrid, 28007, Spain
Hospital Universitario de Navarra /ID# 270119
RECRUITING

Pamplona, Navarre, 31008, Spain
Jewish General Hospital /ID# 268413
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 267672
RECRUITING

Kaohsiung City, 807, Taiwan
Krankenhaus Nordwest /ID# 268462
RECRUITING

Frankfurt am Main, Hesse, 60488, Germany
Linkou Chang Gung Memorial Hospital /ID# 267668
RECRUITING

Taoyuan City, 333, Taiwan
Meir Medical Center /ID# 267998
RECRUITING

Kfar Saba, Central District, 4428164, Israel
Millennium Research & Clinical Development /ID# 268540
RECRUITING

Houston, Texas, 77090, United States
NHS Tayside Health Board /ID# 270799
RECRUITING

Dundee, DD2 1SG, United Kingdom
National Cancer Center Hospital /ID# 268648
RECRUITING

Chuo-Ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East /ID# 268083
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital /ID# 267669
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital /ID# 267666
RECRUITING

Taipei, 100, Taiwan
Oxford University Hospital NHS Trust /ID# 274614
RECRUITING

Oxford, Oxfordshire, OX3 7LE, United Kingdom
Pan American Center for Oncology Trials /ID# 268833
RECRUITING

Rio Piedras, 00935, Puerto Rico
Princess Margaret Cancer Centre /ID# 268277
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Queen Elizabeth Hospital Birmingham /ID# 271199
RECRUITING

Birmingham, B15 2TH, United Kingdom
Shaare Zedek Medical Center /ID# 267752
RECRUITING

Jerusalem, 9103102, Israel
Shizuoka Cancer Center /ID# 268123
RECRUITING

Sunto-gun, Shizuoka, 411-8777, Japan
Soroka Medical Center /ID# 268301
RECRUITING

Beersheba, Southern District, 8410101, Israel
TUM Klinikum rechts der Isar /ID# 267792
RECRUITING

Munich, Bavaria, 81675, Germany
Taipei Veterans General Hospital /ID# 267664
RECRUITING

Taipei, 112, Taiwan
Tel Aviv Sourasky Medical Center /ID# 267755
RECRUITING

Tel Aviv, Tel Aviv, 6423906, Israel
The Cancer Institute Hospital Of JFCR /ID# 268656
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The first Affiliated Hospital, Zhejiang University School of Medicine. /ID# 268782
RECRUITING

Hangzhou, Zhejiang, 310003, China
UCLA - Santa Monica /ID# 270024
RECRUITING

Santa Monica, California, 90404, United States
Union Hospital - Tongji Medical College /ID# 268796
RECRUITING

Wuhan, Hubei, 430022, China
Universitaetsklinikum Freiburg /ID# 270407
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitaetsklinikum Leipzig /ID# 270432
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitair Ziekenhuis Leuven /ID# 269957
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium

Conditions

Explore the condition pages connected to this study.

ESOPHAGEAL ADENOCARCINOMA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA LOCALLY ADVANCED UNRESECTABLE OR METASTATIC GASTRIC ADENOCARCINOMA