Scientists test Triple-Threat attack on Tough-to-Treat lung cancer
NCT ID NCT05353439
Summary
This early-stage study is testing the safety and best dose of a new three-drug combination for small cell lung cancer that has returned after initial treatment. The combination includes a pill (tazemetostat), a chemotherapy (topotecan), and an immunotherapy (pembrolizumab), aiming to attack the cancer in multiple ways. The main goal is to find a safe dose and see if the treatment can shrink or stabilize the cancer in a small group of patients.
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Contacts and locations
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Locations
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Keck Medicine of USC Koreatown
Los Angeles, California, 90020, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461, United States
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NCI - Center for Cancer Research
Bethesda, Maryland, 20892, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California, 92663, United States
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UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Wake Forest University at Clemmons
Clemmons, North Carolina, 27012, United States
Conditions
Explore the condition pages connected to this study.