New hope for Tough-to-Treat colon cancer: major trial tests targeted drug combo

NCT ID NCT06997497

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing if adding two targeted drugs, calderasib and cetuximab, to standard chemotherapy works better for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. It will involve about 477 adults who have not yet received treatment for their advanced cancer. The main goal is to see if the new combination helps people live longer without their cancer getting worse, while also checking how safe it is.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AOU Cagliari ( Site 1306)
RECRUITING

Monserrato, Cagliari, 09042, Italy

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Amphia Ziekenhuis, locatie Breda Molengracht ( Site 1352)
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Breda, North Brabant, 4818 CK, Netherlands

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Amsterdam UMC, locatie VUmc ( Site 1351)
RECRUITING

Amsterdam, North Holland, 1081 HV, Netherlands

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Anhui Provincial Cancer Hospital ( Site 0803)
RECRUITING

Hefei, Anhui, 230031, China

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Asan Medical Center ( Site 0707)
RECRUITING

Songpa-gu, Seoul, 05505, South Korea

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Associação Hospitalar Beneficente São Vicente de Paulo ( Site 0153)
RECRUITING

Passo Fundo, Rio Grande do Sul, 99010-080, Brazil

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Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma ( Site 1304)
RECRUITING

Verona, 37134, Italy

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Azienda Ospedaliera Universitaria dell'Università "Luigi Van-UOC Oncoematologia ( Site 1302)
RECRUITING

Naples, 80131, Italy

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Azienda USL della Romagna ( Site 1303)
RECRUITING

Ravenna, 48100, Italy

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CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0157)
RECRUITING

Florianópolis, Santa Catarina, 88020-210, Brazil

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CHU Charles Nicolle ( Site 1066)
RECRUITING

Rouen, Seine-Maritime, 76031, France

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CNE "Regional Clinical Oncology Center of the Kirovohrad Regional Council" ( Site 1702)
RECRUITING

Kropyvnytskyi, Kirovohrad Oblast, 25011, Ukraine

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COE Ensino e Pesquisa ( Site 0151)
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São José dos Campos, São Paulo, 12242-660, Brazil

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Cancer Institute Hospital of JFCR ( Site 0863)
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Koto, Tokyo, 135-8550, Japan

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Centre François Baclesse ( Site 1061)
RECRUITING

Caen, Calvados, 14000, France

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Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 1053)
RECRUITING

Vandœuvre-lès-Nancy, Lorraine, 54511, France

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Centrul de Oncologie Sfantul Nectarie-Medical ( Site 1500)
RECRUITING

Craiova, Dolj, 200746, Romania

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Chang Gung Memorial Hospital - Linkou Branch ( Site 0753)
RECRUITING

Taoyuan District, 333, Taiwan

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Chongqing University Cancer Hospital ( Site 0808)
RECRUITING

Chongqing, Chongqing Municipality, 400030, China

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Chongqing University Three Gorges Hospital ( Site 0837)
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Wanzhou, Chongqing Municipality, 404199, China

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Churchill Hospital ( Site 1756)
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Oxford, Oxfordshire, ox3 7le, United Kingdom

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Community Cancer Trials of Utah ( Site 0086)
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Ogden, Utah, 84405, United States

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First Affiliated Hospital of Kunming Medical University ( Site 0845)
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Kunming, Yunnan, 650032, China

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First Affiliated Hospital of Shanxi Medical University ( Site 0843)
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Taiyuan, Shanxi, 030001, China

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Fudan University Shanghai Cancer Center ( Site 0816)
RECRUITING

Shanghai, Shanghai Municipality, 200120, China

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Fujian Cancer Hospital ( Site 0807)
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Fuzhou, Fujian, 350014, China

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Fundacion Estudios Clinicos ( Site 0105)
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Rosario, Santa Fe Province, S2000CEJ, Argentina

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Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0159)
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São José do Rio Preto, São Paulo, 15090-000, Brazil

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Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0155)
RECRUITING

Barretos, São Paulo, 14784-400, Brazil

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Fundeni Clinical Institute-Medical Oncology ( Site 1504)
RECRUITING

Bucharest, 022328, Romania

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Greater Baltimore Medical Center ( Site 0068)
RECRUITING

Baltimore, Maryland, 21204, United States

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Guangxi Medical University Affiliated Tumor Hospital ( Site 0804)
RECRUITING

Nanning, Guangxi, 530200, China

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HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1554)
RECRUITING

Madrid, 28007, Spain

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HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 1556)
RECRUITING

Seville, 41013, Spain

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Hadassah Medical Center ( Site 1252)
RECRUITING

Jerusalem, 9112001, Israel

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Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1000)
RECRUITING

Helsinki, Uusimaa, 00290, Finland

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Henan Cancer Hospital ( Site 0822)
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Zhengzhou, Henan, 450008, China

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Hospital Clinico San Carlos ( Site 1555)
RECRUITING

Madrid, 28040, Spain

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Hospital Insular de Gran Canaria ( Site 1558)
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Las Palmas de Gran Canaria, Las Palmas, 35016, Spain

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Hospital Italiano de Buenos Aires ( Site 0102)
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina

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Hospital Nossa Senhora da Conceição ( Site 0156)
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Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

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Hospital Privado Universitario de Córdoba ( Site 0108)
RECRUITING

Córdoba, X5016KEH, Argentina

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Hospital Universitari Vall d'Hebron ( Site 1553)
RECRUITING

Barcelona, 08035, Spain

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Hospital Universitario Central de Asturias ( Site 1550)
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain

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Hospital Universitario Marqués de Valdecilla ( Site 1551)
RECRUITING

Santander, Cantabria, 39008, Spain

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Hospital Universitario San Ignacio ( Site 0254)
RECRUITING

Bogota, Cundinamarca, 110231, Colombia

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Hospital de Caridade de Ijuí ( Site 0150)
RECRUITING

Ijuí, Rio Grande do Sul, 98700-000, Brazil

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Hospital de Câncer de Recife ( Site 0158)
RECRUITING

Recife, Pernambuco, 50040-000, Brazil

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Hubei Cancer Hospital ( Site 0814)
RECRUITING

Wuhan, Hubei, 430079, China

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IBCC - Núcleo de Pesquisa e Ensino ( Site 0154)
RECRUITING

São Paulo, 04014-002, Brazil

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IMAT S.A.S ( Site 0252)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia

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Institut Català d'Oncologia (ICO) - Badalona ( Site 1552)
RECRUITING

Badalona, Barcelona, 08916, Spain

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Institut Jean Godinot ( Site 1054)
RECRUITING

Reims, Marne, 51100, France

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Institut de Cancérologie de l'Ouest ( Site 1062)
RECRUITING

Angers, Pays de la Loire Region, 49055, France

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Instituto Alexander Fleming ( Site 0101)
RECRUITING

Mar del Plata, Buenos Aires, C1426ANZ, Argentina

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Instituto Valenciano de Oncologia - IVO ( Site 1557)
RECRUITING

Valencia, 46009, Spain

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Instituto do Cancer Arnaldo Vieira de Carvalho ( Site 0160)
RECRUITING

São Paulo, 01209-000, Brazil

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Institutul Oncologic Cluj ( Site 1502)
RECRUITING

Cluj-Napoca, Cluj, 400015, Romania

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Institutul Regional de Oncologie ( Site 1505)
RECRUITING

Iași, 700483, Romania

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Istituto Oncologico Veneto IRCCS ( Site 1307)
RECRUITING

Padua, 35128, Italy

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Jinan Central Hospital ( Site 0817)
RECRUITING

Jinan, Shandong, 250013, China

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John Theurer Cancer Center at Hackensack University Medical Center ( Site 0060)
RECRUITING

Hackensack, New Jersey, 07601, United States

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Kagawa University Hospital ( Site 0861)
RECRUITING

Kita-gun, Kagawa-ken, 761-0793, Japan

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Katholisches Marienkrankenhaus gGmbH ( Site 1103)
RECRUITING

Hamburg, 22087, Germany

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Kindai University Hospital ( Site 0854)
RECRUITING

Sakai, Osaka, 590-0197, Japan

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Korea University Guro Hospital ( Site 0704)
RECRUITING

Seoul, 08308, South Korea

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Kyungpook National University Chilgok Hospital ( Site 0701)
RECRUITING

Buk-Gu, Taegu-Kwangyokshi, 41404, South Korea

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LLC "MEDICAL CENTER DOBROBUT-CLINIC" ( Site 1703)
RECRUITING

Kyiv, 03151, Ukraine

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Los Angeles Hematology Oncology Medical Group ( Site 0084)
RECRUITING

Los Angeles, California, 90017, United States

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ME "Volyn Regional Clinical Hospital" of the VRC ( Site 1712)
RECRUITING

Lutsk, Volyn Oblast, +380332773100, Ukraine

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MNE "Central City Hospital" ( Site 1711)
RECRUITING

Rivne, Rivne Oblast, 33017, Ukraine

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MNE "Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of CRC" ( Site 1706)
RECRUITING

Cherkasy, Cherkasy Oblast, 18009, Ukraine

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MNPE "Prykarpattia Clinical Oncology Center of Ivano-Frankivsk Regional Council" ( Site 1701)
RECRUITING

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine

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MNPE LTMU Multidisc. Clin. Hosp. of Emerg. and Intens. Care ( Site 1708)
RECRUITING

Lviv, Lviv Oblast, 79059, Ukraine

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Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 1704)
RECRUITING

Kyiv, 03057, Ukraine

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Miami Valley Hospital South ( Site 0075)
RECRUITING

Centerville, Ohio, 45459, United States

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Monash Health ( Site 0454)
RECRUITING

Clayton, Victoria, 3168, Australia

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Moncton Hospital - Horizon Health Network ( Site 0011)
RECRUITING

Moncton, New Brunswick, E1C 6Z8, Canada

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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 0825)
RECRUITING

Nanjing, Jiangsu, 210000, China

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National Cancer Center ( Site 0702)
RECRUITING

Goyang-si, Kyonggi-do, 10408, South Korea

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National Cancer Center Hospital ( Site 0850)
RECRUITING

Chūō, Tokyo, 104-0045, Japan

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National Cancer Center Hospital East ( Site 0851)
RECRUITING

Kashiwa, Chiba, 277-8577, Japan

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National Cancer Centre Singapore ( Site 0650)
RECRUITING

Singapore, Central Singapore, 168583, Singapore

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National Cheng Kung University Hospital ( Site 0754)
RECRUITING

Tainan, 704, Taiwan

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National Taiwan University Hospital ( Site 0751)
RECRUITING

Taipei, 100, Taiwan

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Nippon Medical School Hospital ( Site 0859)
RECRUITING

Bunkyo, Tokyo, 113-8603, Japan

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Norton Cancer Institute, Audubon Hospital Campus ( Site 0054)
RECRUITING

Louisville, Kentucky, 40217, United States

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Oncologos Del Occidente ( Site 0255)
RECRUITING

Pereira, Risaralda Department, 660001, Colombia

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Orlando Health Cancer Institute ( Site 0065)
RECRUITING

Orlando, Florida, 32806, United States

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Ospedale San Raffaele. ( Site 1305)
RECRUITING

Milan, 20132, Italy

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Peking Union Medical College Hospital ( Site 0824)
RECRUITING

Beijing, Beijing Municipality, 100730, China

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Prince of Wales Hospital. ( Site 0500)
RECRUITING

Hong Kong, Hong Kong

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Princess Margaret Cancer Centre ( Site 0001)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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Queen Mary Hospital ( Site 0501)
RECRUITING

Hong Kong, Hong Kong

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RMNE "Bukovyna Clinical Oncology Center" ( Site 1709)
RECRUITING

Chernivtsi, Chernivetska Oblast, 58013, Ukraine

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Rabin Medical Center ( Site 1251)
RECRUITING

Petah Tikva, 4941492, Israel

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Radboudumc ( Site 1354)
RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands

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Rambam Health Care Campus ( Site 1253)
RECRUITING

Haifa, 3109601, Israel

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Renown Regional Medical Center ( Site 0056)
RECRUITING

Reno, Nevada, 89502, United States

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SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 1501)
RECRUITING

Cluj-Napoca, Cluj, 407280, Romania

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SI "National Institute of Surgery and Transplantology named after O. O. Shalimov" ( Site 1713)
RECRUITING

Kyiv, 03126, Ukraine

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Sainte Catherine Institut du Cancer Avignon Provence ( Site 1065)
RECRUITING

Avignon, Vaucluse, 84918, France

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Saitama Medical University International Medical Center ( Site 0860)
RECRUITING

Hidaka, Saitama, 350-1298, Japan

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Samsung Medical Center ( Site 0708)
RECRUITING

Gangnam, Seoul, 06351, South Korea

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Seoul National University Bundang Hospital ( Site 0705)
RECRUITING

Seongnam-si, Kyonggi-do, 13620, South Korea

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Seoul National University Hospital ( Site 0706)
RECRUITING

Seoul, 03080, South Korea

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Sheba Medical Center ( Site 1254)
RECRUITING

Ramat Gan, 5265601, Israel

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Sichuan Cancer hospital. ( Site 0831)
RECRUITING

Chengdu, Sichuan, 610213, China

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Southern Medical University Nanfang Hospital ( Site 0812)
RECRUITING

Guangzhou, Guangdong, 510515, China

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Sun Yat-Sen University Cancer Center ( Site 0800)
RECRUITING

Guangzhou, Guangdong, 510060, China

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Sunshine Coast University Hospital ( Site 0451)
RECRUITING

Birtinya, Queensland, 4575, Australia

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Taipei Veterans General Hospital ( Site 0752)
RECRUITING

Taipei, 112, Taiwan

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Tampere University Hospital ( Site 1001)
RECRUITING

Tampere, Pirkanmaa, 33520, Finland

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Teine Keijinkai Hospital ( Site 0864)
RECRUITING

Sapporo, Hokkaido, 006-8555, Japan

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The Catholic University of Korea St. Vincent s Hospital ( Site 0703)
RECRUITING

Suwon, Kyonggi-do, 16247, South Korea

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The Christie NHS Foundation Trust ( Site 1755)
RECRUITING

Manchester, M20 4BX, United Kingdom

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The First Affiliated Hospital of Nanchang University ( Site 0826)
RECRUITING

Nanchang, Jiangxi, 330200, China

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The First Affiliated Hospital of Wenzhou Medical University ( Site 0840)
RECRUITING

Wenzhou, Zhejiang, 325000, China

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The First Affiliated Hospital of Xiamen University ( Site 0806)
RECRUITING

Xiamen, Fujian, 361003, China

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The Second Affiliated Hospital of Anhui Medical University ( Site 0813)
RECRUITING

Hefei, Anhui, 230601, China

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The Second Affiliated Hospital of Zhejiang University School of Medicine ( Site 0801)
RECRUITING

Hangzhou, Zhejiang, 310017, China

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The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 0828)
RECRUITING

Guangzhou, Guangdong, 510655, China

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The Third Xiangya Hospital of Central South University ( Site 0834)
RECRUITING

Changsha, Hunan, 410013, China

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Tohoku University Hospital ( Site 0853)
RECRUITING

Sendai, Miyagi, 980-8574, Japan

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Tongji Hospital Tongji Medical,Science & Technology ( Site 0839)
RECRUITING

Wuhan, Hubei, 430030, China

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University College London Hospitals ( Site 1750)
RECRUITING

London, London, City of, NW1 2PG, United Kingdom

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University Of Nebraska Medical Center ( Site 0078)
RECRUITING

Omaha, Nebraska, 68198, United States

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University of Iowa ( Site 0074)
RECRUITING

Iowa City, Iowa, 52242, United States

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University of Kentucky ( Site 0055)
RECRUITING

Lexington, Kentucky, 40536, United States

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University of Virginia ( Site 0080)
RECRUITING

Charlottesville, Virginia, 22908, United States

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Uzhgorod Central City Clinical Hospital ( Site 1700)
RECRUITING

Uzhhorod, Zakarpattia Oblast, 88000, Ukraine

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Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie ( Site 1457)
RECRUITING

Poznan, Greater Poland Voivodeship, 61-866, Poland

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Zhejiang Cancer Hospital ( Site 0821)
RECRUITING

Hangzhou, Zhejiang, 310022, China

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Conditions

Explore the condition pages connected to this study.

COLON ADENOCARCINOMA RECTAL ADENOCARCINOMA