Major cancer trial tests new drug combo against standard treatment

NCT ID NCT06662786

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding a newer drug called amivantamab to standard chemotherapy works better than the current standard treatment (cetuximab plus chemotherapy) for people with advanced left-sided colon or rectal cancer that has spread and cannot be removed by surgery. It will involve about 1000 adults with a specific genetic profile (KRAS/NRAS/BRAF wild-type). The main goal is to see which treatment keeps the cancer from growing for a longer time.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AZ Maria Middelares
RECRUITING

Ghent, 9000, Belgium
Adana City Hospital
RECRUITING

Adana, 01060, Turkey (Türkiye)
Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
AdventHealth Medical Group Oncology and Hematology at Orlando
RECRUITING

Orlando, Florida, 32804, United States
Aichi Cancer Center
RECRUITING

Nagoya, 464 8681, Japan
Ankara Bilkent Sehir Hastanesi
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Antoni van Leeuwenhoek
RECRUITING

Amsterdam, 1066 CX, Netherlands
Arthur J E Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Asklepios Klinik Altona
RECRUITING

Hamburg, 22763, Germany
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia
RECRUITING

Vitória, 29043 260, Brazil
Assuta MC
RECRUITING

Tel Aviv, 69710, Israel
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
Az Groeninge
RECRUITING

Kortrijk, 8500, Belgium
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, 56126, Italy
B P Poddar Hospital and Medical research Limited
RECRUITING

Kolkata, 700053, India
Bakirkoy Training and Research Hospital
RECRUITING

Istanbul, 34147, Turkey (Türkiye)
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Baylor Scott and White Health
RECRUITING

Temple, Texas, 76508, United States
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Beijing Friendship Hospital Capital Medical University
RECRUITING

Beijing, 100050, China
Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku
RECRUITING

Bialystok, 15 027, Poland
Birmingham Heartlands Hospital
RECRUITING

Birmingham, B9 5ST, United Kingdom
CBCC Global Research
RECRUITING

Bakersfield, California, 93309, United States
CHU De Poitiers
RECRUITING

Poitiers, 86000, France
CHU Nantes
RECRUITING

Nantes, 44000, France
Cancer and Blood Specialty Clinic
RECRUITING

Los Alamitos, California, 90720, United States
Castle Hill Hospital
RECRUITING

Hull, HU16 5JQ, United Kingdom
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman
RECRUITING

Liège, 4000, Belgium
Centre de Recherche du CHUM
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie
RECRUITING

Warsaw, 02 781, Poland
Charite Universitatsmedizin Berlin Campus Virchow Klinikum
RECRUITING

Berlin, 13353, Germany
Chiba Cancer Center
RECRUITING

Chiba, 260 0801, Japan
Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion
RECRUITING

Cleveland, Ohio, 44111, United States
Cleveland Clinic Cancer Center Hillcrest Hospital
RECRUITING

Mayfield Heights, Ohio, 44124, United States
Cleveland Clinic Cancer Center Independence Family Health Center
RECRUITING

Independence, Ohio, 44131, United States
Cleveland Clinic Cancer Center Mansfield
RECRUITING

Mansfield, Ohio, 44906, United States
Cleveland Clinic Cancer Center South Pointe Hospital
RECRUITING

Warrensville Heights, Ohio, 44122, United States
Cleveland Clinic Cancer Center Strongsville
RECRUITING

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Centers Sandusky
RECRUITING

Sandusky, Ohio, 44870, United States
Clinica Univ. de Navarra
RECRUITING

Pamplona, 31008, Spain
Clinica de Hematologia e Oncologia Viver Ltda
RECRUITING

Santa Maria, 97015 450, Brazil
Comprehensive Cancer Centers of Nevada
RECRUITING

Las Vegas, Nevada, 89169, United States
Deenanath Mangeshkar Hospital and Research Centre
RECRUITING

Pune, 411004, India
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Elisabeth-TweeSteden Ziekenhuis
RECRUITING

Tilburg, 5022 GC, Netherlands
Erasmus MC
RECRUITING

Rotterdam, 3015 GD, Netherlands
Essen University Hospital
RECRUITING

Essen, 45147, Germany
First Hospital of Shanxi Medical University
RECRUITING

Taiyuan, 030001, China
Florida Cancer Specialists East
RECRUITING

West Palm Beach, Florida, 33401-3406, United States
Florida Cancer Specialists North Region
RECRUITING

St. Petersburg, Florida, 33701-4553, United States
Florida Cancer Specialists South
RECRUITING

Fort Myers, Florida, 33901, United States
Fort Wayne Medical Oncology & Hematology
RECRUITING

Fort Wayne, Indiana, 46804, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, 200032, China
Fundacao Antonio Prudente A C Camargo Cancer Center
RECRUITING

São Paulo, 01509 900, Brazil
Fundacao Doutor Amaral Carvalho
RECRUITING

Jaú, 17210 080, Brazil
Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base
RECRUITING

São José do Rio Preto, 15090 000, Brazil
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo
RECRUITING

São Paulo, 01246 000, Brazil
Fundacao Pio XII
RECRUITING

Barretos, 14780 070, Brazil
Fundacao Universidade de Caxias do Sul
RECRUITING

Caxias do Sul, 95070 560, Brazil
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
Gazi Universitesi Hastanesi
RECRUITING

Ankara, 06560, Turkey (Türkiye)
Georgetown Univ Medical Center Lombardi Cancer Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Grady Memorial Hospital
RECRUITING

Atlanta, Georgia, 30303, United States
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, 519041, China
Gulhane Egitim ve Arastirma Hastanesi
RECRUITING

Ankara, 06010, Turkey (Türkiye)
Gustave Roussy
RECRUITING

Villejuif, 94805, France
Hadassah University Hospita Ein Kerem
RECRUITING

Jerusalem, 9112001, Israel
Harbin medical university cancer hospital
RECRUITING

Harbin, 150081, China
Hattiesburg Clinic
RECRUITING

Hattiesburg, Mississippi, 39401, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Hopital Claude Huriez
RECRUITING

Lille, 59000, France
Hopital Haut Leveque
RECRUITING

Pessac, 33604, France
Hopital Prive Jean Mermoz
RECRUITING

Lyon, 69008, France
Hopital Saint Antoine
RECRUITING

Paris, 75571, France
Hopital de Jolimont
RECRUITING

Haine Saint Paul La Louviere, 7100, Belgium
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hosp. Clinico Univ. de Valencia
RECRUITING

Valencia, 46010, Spain
Hosp. Gral. Univ. Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hosp. Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hosp. de La Santa Creu I Sant Pau
RECRUITING

Barcelona, 08025, Spain
Hospital Canselor Tuanku Muhriz UKM
RECRUITING

Cheras, 56000, Malaysia
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 50586, Malaysia
Hospital Nossa Senhora da Conceicao S A
RECRUITING

Porto Alegre, 91350 200, Brazil
Hospital Pulau Pinang
RECRUITING

George Town, 10450, Malaysia
Hospital Raja Permaisuri Bainun
RECRUITING

Ipoh, 30450, Malaysia
Hospital Santa Izabel Santa Casa de Misericordia da Bahia
RECRUITING

Salvador, 40050 410, Brazil
Hospital Umum Sarawak
RECRUITING

Kuching, 93586, Malaysia
Hubei Cancer Hospital
RECRUITING

Wuhan, 430079, China
Huizhou Central People's Hospital
RECRUITING

Huizhou, 516001, China
Hunan Cancer hospital
RECRUITING

Changsha, 410013, China
Illinois CancerCare
RECRUITING

Peoria, Illinois, 61615, United States
Inova Schar Cancer Institute Dept of Fairfax Hospital
RECRUITING

Fairfax, Virginia, 22031, United States
Institut Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Institut Sainte Catherine
RECRUITING

Avignon, 84918, France
Institut du Cancer de Montpellier
RECRUITING

Montpellier, 34298, France
Instytut Centrum Zdrowia Matki Polki
RECRUITING

Lodz, 93 339, Poland
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Dei Tumori Di Milano
RECRUITING

Milan, 20133, Italy
Istituto Oncologico Veneto - IRCCS
RECRUITING

Padua, 35128, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
RECRUITING

Meldola, 47014, Italy
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 83301, Taiwan
Kaohsiung Medical University Chung Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Karolinska Universitetssjukhuset
RECRUITING

Stockholm, 171 76, Sweden
Klinikum der Universitaet Muenchen
RECRUITING

Munich, 81377, Germany
Krankenhaus NorthWest
RECRUITING

Frankfurt am Main, 60488, Germany
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, 41404, South Korea
Liaoning Cancer Hospital and Institute
RECRUITING

Shenyang, 110042, China
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan District, 333, Taiwan
Los Angeles Cancer Network
RECRUITING

Glendale, California, 91204, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Mahamana Pandit Madan Mohan Malviya Cancer Centre
RECRUITING

Varanasi, 221005, India
Markhot Ferenc Oktatokorhaz es Rendelointezet
RECRUITING

Eger, 3300, Hungary
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
RECRUITING

Istanbul, 34899, Turkey (Türkiye)
Meander Medisch Centrum
RECRUITING

Amersfoort, 3813 TZ, Netherlands
MedStar Franklin Square Medical Center
RECRUITING

Baltimore, Maryland, 21237, United States
Montefiore Einstein Comprehensive Cancer Center
RECRUITING

The Bronx, New York, 10461, United States
Mount Sinai
RECRUITING

New York, New York, 10003, United States
Mount Sinai West
RECRUITING

New York, New York, 10009, United States
Mount Vernon Cancer Centre
RECRUITING

Northwood, HA6 2RN, United Kingdom
NYU Langone Medical Center NYU Hematology Associates
RECRUITING

New York, New York, 10016, United States
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach
RECRUITING

Gliwice, 44 100, Poland
National Cancer Center Hospital
RECRUITING

Chūōku, 104 0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277 8577, Japan
National Cancer Institute
RECRUITING

Putrajaya, 62250, Malaysia
National Center for Tumor Diseases NCT
RECRUITING

Heidelberg, 69120, Germany
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Osaka National Hospital
RECRUITING

Osaka, 540 0006, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10043, Taiwan
Nebraska Cancer Specialists Midwest Cancer Center
RECRUITING

Omaha, Nebraska, 68130, United States
Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi
RECRUITING

Konya, 42090, Turkey (Türkiye)
New York Cancer and Blood Specialists
RECRUITING

Shirley, New York, 11967, United States
Ochsner Clinic Foundation
RECRUITING

New Orleans, Louisiana, 70121, United States
Oregon Health And Science University
RECRUITING

Portland, Oregon, 97239, United States
Osaka International Cancer Institute
RECRUITING

Osaka, 541 8567, Japan
Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Pan American Center for Oncology Trials LLC
RECRUITING

Barrio Monacillos, 00935, Puerto Rico
Pecsi Tudomanyegyetem
COMPLETED

Pécs, 7624, Hungary
Peking University First Hospital
RECRUITING

Beijing, 100034, China
Peking University Shenzhen Hospital
RECRUITING

Shenzhen, 518036, China
Peking University Third Hospital
RECRUITING

Beijing, 100191, China
Perlmutter Cancer Center at NYU Long Island
RECRUITING

Mineola, New York, 11501, United States
Praxis fur interdisziplinare Onkologie & Hamatologie GbR
RECRUITING

Freiburg im Breisgau, 79110, Germany
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G1X6, Canada
Providence Medical Foundation
RECRUITING

Santa Rosa, California, 95403, United States
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Radboud University Medical Center
RECRUITING

Nijmegen, 6525 GA, Netherlands
Rajiv Gandhi Cancer Institute and Research Centre
RECRUITING

Delhi, 110085, India
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Richmond VA Medical Center
RECRUITING

Richmond, Virginia, 23249, United States
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Royal Marsden Hospital (Sutton)
RECRUITING

Sutton, SM2 5PT, United Kingdom
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08901, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie
RECRUITING

Olsztyn, 10 228, Poland
SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego
RECRUITING

Opole, 45 061, Poland
Sahlgrenska University Hospital
RECRUITING

Gothenburg, 413 45, Sweden
Sakarya University Training and Research Hospital
RECRUITING

Sakarya, 54290, Turkey (Türkiye)
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Semmelweis Egyetem
RECRUITING

Budapest, 1082, Hungary
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
Shizuoka Cancer Center
RECRUITING

Shizuoka, 411 8777, Japan
Skanes universitetssjukhus
RECRUITING

Lund, 222 42, Sweden
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
RECRUITING

São Paulo, 05651 900, Brazil
Sodersjukhuset
RECRUITING

Stockholm, 118 83, Sweden
St Bartholomew's Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
St James University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
St. Bernard's Medical Center
RECRUITING

Jonesboro, Arkansas, 72401, United States
Start Midwest
RECRUITING

Grand Rapids, Michigan, 49503, United States
Sun Yat Sen University Cancer Center
RECRUITING

Guangzhou, 510062, China
Swedish Cancer Institute
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Cancer Institute
RECRUITING

Issaquah, Washington, 98029, United States
Swedish Cancer Institute
RECRUITING

Seattle, Washington, 98104, United States
Szegedi Tudomanyegyetem
RECRUITING

Szeged, 6720, Hungary
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza
RECRUITING

Brzozów, 36 200, Poland
Tata Memorial Hospital
RECRUITING

Mumbai, 400012, India
Taussig Cancer Insititute Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology DFW
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology West Texas
RECRUITING

Abilene, Texas, 79606, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Tokyo, 135 8550, Japan
The Catholic University of Korea Seoul St Marys Hospital
RECRUITING

Seoul, 06591, South Korea
The First Affiliated Hospital Zhejiang University College of Medicine
RECRUITING

Hangzhou, 310003, China
The First Affiliated Hospital of NanChang University
RECRUITING

Nanchang, 330006, China
The First Bethune Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The Second Affiliated Hospital of Zhejiang University College of Medicine
RECRUITING

Hangzhou, 310009, China
The Sixth Affiliated Hospital Sun Yat sen University
RECRUITING

Guangzhou, 510655, China
The University of Osaka Hospital
RECRUITING

Suita, 565 0871, Japan
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tianjin Medical University Cancer Institute and Hospital
RECRUITING

Tianjin, 300060, China
Torrance Memorial Physicians Network
RECRUITING

Torrance, California, 90505, United States
UCLA
RECRUITING

Santa Monica, California, 90404, United States
UMC Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Southwestern
RECRUITING

Dallas, Texas, 75390, United States
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, 01307, Germany
Universitair Ziekenhuis Antwerpen
RECRUITING

Edegem, 2650, Belgium
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium
Universitatsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Universitatsmedizin der Johannes Gutenberg Universitat Mainz
RECRUITING

Mainz, 55131, Germany
University College Hospital
RECRUITING

London, NW1 2BU, United Kingdom
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, 59100, Malaysia
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232 1301, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87102, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80 214, Poland
Uppsala University
RECRUITING

Uppsala, SE 751 85, Sweden
VA Ann Arbor Healthcare System
RECRUITING

Ann Arbor, Michigan, 48105, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Virginia Cancer Specialists
RECRUITING

Arlington, Virginia, 22201, United States
Washington University School Of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
West China Hospital of Sichuan University
RECRUITING

Sichuan, 610044, China
Western General Hospital
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
William S. Middleton Memorial VA
RECRUITING

Madison, Wisconsin, 53705, United States
Winship Cancer Institute Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Wojewodzki Szpital Specjalistyczny
RECRUITING

Biała Podlaska, 21 500, Poland
Wooster Milltown Specialty and Surgery Center
RECRUITING

Wooster, Ohio, 44691, United States
Yale University School Of Medicine
RECRUITING

New Haven, Connecticut, 06519, United States
Yitzhak Shamir Medical Center
RECRUITING

Beer Yaakov, 70300, Israel
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, 310022, China

Conditions

Explore the condition pages connected to this study.

COLORECTAL NEOPLASMS