New drug duo tested to tame dangerous transplant complication

NCT ID NCT06388564

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding a new drug called axatilimab to an existing drug (ruxolitinib) works better for controlling chronic Graft-Versus-Host Disease (cGVHD). It will involve about 120 people aged 12 and older who have recently been diagnosed with moderate or severe cGVHD after a stem cell transplant. The main goal is to see if the combination helps more patients improve within 6 months and is safe to use.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

A.O.U. Citta Della Salute E Della Scienza Di Torino
RECRUITING

Torino, 10126, Italy
AZ DELTA
RECRUITING

Roeselare, 08800, Belgium
Aou Policlinico S. Orsola-Malpighi
RECRUITING

Bologna, 40138, Italy
Arthur J E Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T3N 4N1, Canada
Az Sint-Jan Brugge - Oostende Av - Campus Sint-Jan
RECRUITING

Bruges, 08000, Belgium
Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii
RECRUITING

Bergamo, 24127, Italy
Cambridge University Hospitals Nhs Foundation Trust
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Centre Hospitalier Universitaire (Chu) de Liege
RECRUITING

Liège, 04000, Belgium
Chu Sainte-Justine
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
Clatterbridge Cancer Center
RECRUITING

Liverpool, L7 8YA, United Kingdom
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Fondazione Irccs Ca Granda Ospedale Maggiore Policlinico Di Milano Uo Dermatologia
RECRUITING

Milan, 20122, Italy
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Fred and Pamela Buffett Cancer Center
RECRUITING

Omaha, Nebraska, 68198, United States
Froedtert & the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Hospital Clinic Barcelona Main
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hospital General Universitario Vall D Hebron
WITHDRAWN

Barcelona, 08035, Spain
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29011, Spain
Hospital Universitari I Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Marques de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen de La Arrixaca
RECRUITING

El Palmar, 30120, Spain
Hospital Universitario Virgen de Las Nieves
RECRUITING

Granada, 18014, Spain
Ico Institut Catala D Oncologia
RECRUITING

Granvia de L'hospitalet 199-203, 08908, Spain
Irccs Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Jessa Ziekenhuis
RECRUITING

Hasselt, 03500, Belgium
Klinikum Der Johann Wolfgang Goethe University
RECRUITING

Frankfurt am Main, 60590, Germany
Massachusetts General Hospital
WITHDRAWN

Boston, Massachusetts, 02144, United States
Mayo Clinic Hospital
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Ospedale Pediatrico Bambino Gesu Irccs
RECRUITING

Rome, 00165, Italy
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore
RECRUITING

Rome, 00168, Italy
Princess Margaret Cancer Centre - University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Queen Elizabeth Hospital
RECRUITING

Birmingham, B15 2TH, United Kingdom
Queen Elizabeth University Hospital
RECRUITING

Glasgow, G51 4TF, United Kingdom
Smilow Cancer Center-Yale
RECRUITING

New Haven, Connecticut, 06510, United States
St James University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
Stanford Cancer Center
RECRUITING

Stanford, California, 94305, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The University of Chicago Medicine
NOT_YET_RECRUITING

Chicago, Illinois, 60637, United States
Universitaetsklinikum Jena
RECRUITING

Jena, 07747, Germany
Universitaetsklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany
Universitair Ziekenhuis (Uz) Leuven
RECRUITING

Leuven, 03000, Belgium
Universitair Ziekenhuis Antwerpen (Uza)
RECRUITING

Edegem, 02650, Belgium
Universitaire Ziekenhuis Leuven - Gasthuisberg
RECRUITING

Leuven, 03000, Belgium
Universitatklinikum Freiburg
RECRUITING

Freiburg im Breisgau, 79106, Germany
Universitatsklinikum Hamburg Eppendorf
RECRUITING

Hamburg, 20251, Germany
University Hospital Mannheim
RECRUITING

Mannheim, 68167, Germany
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
University of California-Los Angeles Medl Cntr-Oncology Center Bowyer Clinic
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
University of Maryland-Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Pennsylvania Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Vancouver General Hospital
RECRUITING

Vancouver, V5Z1M9, Canada
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medicine
RECRUITING

New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.

CHRONIC GRAFT VERSUS HOST DISEASE