Major trial tests new drug combo to control dangerous transplant complication

NCT ID NCT06143891

Ongoing Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding the drug belumosudil to standard steroid treatment works better than steroids alone for people newly diagnosed with moderate or severe chronic graft-versus-host disease (cGVHD). cGVHD is a serious complication that can occur after a stem cell or bone marrow transplant. The trial will involve about 260 participants aged 12 and older to see if the combination helps control the disease longer, reduces symptoms, and allows patients to use less steroids.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AZ Delta-Investigational Site Number : 0560002

Roeselare, 8800, Belgium
AdventHealth Orlando- Site Number : 8400023

Orlando, Florida, 32803, United States
Amsterdam Universitair Medisch Centrum-Site Number : 5280005

Amsterdam, 1081 HV, Netherlands
Atrium Health Wake Forest Baptist Medical Center - Winston-Salem - Medical Center Boulevard- Site Number : 8400007

Winston-Salem, North Carolina, 27157, United States
CHU Bordeaux-Hôpital Haut-Lévêque-Investigational Site Number : 2500002

Pessac, 33600, France
CHU Hotel Dieu-Investigational Site Number : 2500005

Nantes, 44093, France
CHU Sainte-Justine-Site Number : 1240003

Montreal, Quebec, H3T1C5, Canada
CHU de Liège-Investigational Site Number : 0560004

Liège, 4000, Belgium
City of Hope National Medical Center- Site Number : 8400001

Duarte, California, 91010, United States
Cliniques Universitaires St. Luc-Investigational Site Number : 0560005

Woluwe, Brussels Capital, 1200, Belgium
Dana Farber Cancer Institute Site Number : 8400005

Boston, Massachusetts, 02115, United States
Department of hematology-Investigational Site Number : 2080001

Aarhus, Jutland, 8200, Denmark
Fred Hutchinson Cancer Research Center- Site Number : 8400004

Seattle, Washington, 98109, United States
Fundação Faculdade Regional de Medicina de São José do Rio Preto- Site Number : 0760006

São José do Rio Preto, São Paulo, 15090-000, Brazil
General Hospital of Thessaloniki "George Papanikolaou"-Site Number : 3000001

Thessaloniki, 570 10, Greece
Hospital Israelita Albert Einstein- Site Number : 0760003

São Paulo, 05651-901, Brazil
Hospital Niño Jesús-Site Number : 7240002

Madrid, 28009, Spain
Hospital Regional Universitarioa de Malaga-Site Number : 7240003

Málaga, 29010, Spain
Hospital Universitari i Politècnic La Fe-Site Number : 7240001

Valencia, 46026, Spain
Hospital Universitario Virgen del Rocío.-Site Number : 7240008

Seville, 41013, Spain
Hospital Universitario de Salamanca-Site Number : 7240007

Salamanca, 37007, Spain
Hospital das Clinicas FMUSP- Site Number : 0760004

São Paulo, 05403-000, Brazil
Hospital de Clinicas da Universidade Federal do Parana- Site Number : 0760008

Curitiba, Paraná, 80060-900, Brazil
Hôpital Lyon Sud-Investigational Site Number : 2500007

Pierre-Bénite, 69310, France
Hôpital Maisonneuve Rosemont-Investigational Site Number : 1240001

Montreal, Quebec, H1T 2M4, Canada
Hôpital Pontchaillou - CHU de Rennes-Investigational Site Number : 2500008

Rennes, 35033, France
ICO Institut Català d'Oncologia-Site Number : 7240006

Barcelona, Catalunya [Cataluña], 08908, Spain
INCA - Hospital do Câncer - Rio de Janeiro - Praça Da Cruz Vermelha- Site Number : 0760007

Rio de Janeiro, 20230-130, Brazil
IV. Interni hematologicka klinika, Fakultni nemocnice Hradec Kralove-Site Number : 2030002

Hradec Králové, 50005, Czechia
Indiana University Health University Hospital- Site Number : 8400006

Indianapolis, Indiana, 46202, United States
Institut Paoli Calmettes-Investigational Site Number : 2500004

Marseille, 13273, France
Interni hematologicka a onkologicka klinika Fakultni nemocnice Brno-Site Number : 2030003

Brno, 62500, Czechia
Investigational Site Number : 0320001

Buenos Aires, 1426, Argentina
Investigational Site Number : 0320002

Buenos Aires, 1431, Argentina
Investigational Site Number : 0320003

Buenos Aires, 1280, Argentina
Investigational Site Number : 0320004

Córdoba, 5000, Argentina
Investigational Site Number : 0320005

Buenos Aires, 1227, Argentina
Investigational Site Number : 0320006

Pilar, Buenos Aires, 1629, Argentina
Investigational Site Number : 0360001

Melbourne, Victoria, 3000, Australia
Investigational Site Number : 0360003

Brisbane, Queensland, 4029, Australia
Investigational Site Number : 0360004

Murdoch, Western Australia, 6150, Australia
Investigational Site Number : 0360005

Westmead, New South Wales, 2145, Australia
Investigational Site Number : 0400001

Linz, 4020, Austria
Investigational Site Number : 0400003

Graz, 8036, Austria
Investigational Site Number : 0400004

Vienna, 1090, Austria
Investigational Site Number : 0560006

Bruges, 8000, Belgium
Investigational Site Number : 1240002

Montreal, Quebec, H4A 3J1, Canada
Investigational Site Number : 1240005

Toronto, Ontario, M5G 2M9, Canada
Investigational Site Number : 1240007

Calgary, Alberta, T2N 5G2, Canada
Investigational Site Number : 1240008

Saskatoon, Saskatchewan, S7N 4H4, Canada
Investigational Site Number : 1560001

Suzhou, 215006, China
Investigational Site Number : 1560002

Hangzhou, 310003, China
Investigational Site Number : 1560003

Tianjin, 300020, China
Investigational Site Number : 1560004

Tianjin, 300020, China
Investigational Site Number : 1560005

Guangzhou, 510000, China
Investigational Site Number : 1560006

Suzhou, 215025, China
Investigational Site Number : 1560007

Jinan, 250014, China
Investigational Site Number : 1560008

Jinan, 250001, China
Investigational Site Number : 1560009

Zhengzhou, 450008, China
Investigational Site Number : 1560010

Changsha, 410008, China
Investigational Site Number : 1560011

Fuzhou, 350001, China
Investigational Site Number : 1560012

Changchun, 130021, China
Investigational Site Number : 1560013

Wuhan, 430022, China
Investigational Site Number : 1560014

Hefei, 230001, China
Investigational Site Number : 1560015

Wuhan, 430030, China
Investigational Site Number : 1560019

Beijing, 100050, China
Investigational Site Number : 2500001

Paris, 75571, France
Investigational Site Number : 2500003

Paris, 75010, France
Investigational Site Number : 2500006

Vandœuvre-lès-Nancy, 54511, France
Investigational Site Number : 2760001

Dresden, 01307, Germany
Investigational Site Number : 2760002

Hamburg, 20246, Germany
Investigational Site Number : 2760003

Cologne, 50937, Germany
Investigational Site Number : 2760005

Freiburg im Breisgau, 79106, Germany
Investigational Site Number : 2760006

Regensburg, 93053, Germany
Investigational Site Number : 2760007

Berlin, 13353, Germany
Investigational Site Number : 2760008

Tübingen, 72076, Germany
Investigational Site Number : 2760009

Münster, 48149, Germany
Investigational Site Number : 2760010

Kiel, 24105, Germany
Investigational Site Number : 3440001

Pok Fu Lam, 999077, Hong Kong
Investigational Site Number : 3760001

Tel Aviv, 6423906, Israel
Investigational Site Number : 3760002

Haifa, 3109601, Israel
Investigational Site Number : 3760003

Ramat Gan, 5262100, Israel
Investigational Site Number : 3760004

Ramat Gan, 5262100, Israel
Investigational Site Number : 3760005

Jerusalem, 9112001, Israel
Investigational Site Number : 3760006

Petah Tikva, 4920235, Israel
Investigational Site Number : 3800001

Rome, Roma, 00168, Italy
Investigational Site Number : 3800002

Rozzano, Milano, 20089, Italy
Investigational Site Number : 3800003

Bergamo, 24127, Italy
Investigational Site Number : 3800004

Bologna, 40138, Italy
Investigational Site Number : 3800005

Genoa, Genova, 16132, Italy
Investigational Site Number : 3800006

Reggio Calabria, 89133, Italy
Investigational Site Number : 3800007

Turin, Torino, 10126, Italy
Investigational Site Number : 3800008

Udine, 33100, Italy
Investigational Site Number : 3800009

Milan, Milano, 20132, Italy
Investigational Site Number : 3800010

Perugia, 06156, Italy
Investigational Site Number : 3800011

Pavia, 27100, Italy
Investigational Site Number : 3800012

Torette, Ancona, 60020, Italy
Investigational Site Number : 4100001

Seoul, Seoul-teukbyeolsi, 06591, South Korea
Investigational Site Number : 4100002

Seoul, Seoul-teukbyeolsi, 03080, South Korea
Investigational Site Number : 4100003

Seoul, Seoul-teukbyeolsi, 03722, South Korea
Investigational Site Number : 4100004

Seoul, Seoul-teukbyeolsi, 06351, South Korea
Investigational Site Number : 5280001

Utrecht, 3584 CS, Netherlands
Investigational Site Number : 5280002

Rotterdam, 3015 CE, Netherlands
Investigational Site Number : 5280003

Groningen, 9713 GR, Netherlands
Investigational Site Number : 6160001

Gdansk, Pomeranian Voivodeship, 80-952, Poland
Investigational Site Number : 6160008

Szczecin, 71-252, Poland
Investigational Site Number : 6200002

Lisbon, 1649-035, Portugal
Investigational Site Number : 6200003

Lisbon, 1099-023, Portugal
Investigational Site Number : 7240004

Madrid, 28007, Spain
Investigational Site Number : 7240005

Barcelona, Catalunya [Cataluña], 08036, Spain
Investigational Site Number : 7240011

Santander, Cantabria, 39008, Spain
Investigational Site Number : 7240012

Valencia, 46010, Spain
Investigational Site Number : 7520001

Huddinge, 141 57, Sweden
Investigational Site Number : 7520002

Lund, 221 85, Sweden
Investigational Site Number : 7520003

Gothenburg, 413 45, Sweden
Investigational Site Number : 7920001

Ankara, 06620, Turkey (Türkiye)
Investigational Site Number : 7920002

Ankara, 06200, Turkey (Türkiye)
Investigational Site Number : 7920003

Izmir, 35100, Turkey (Türkiye)
Investigational Site Number : 7920004

Ankara, 06560, Turkey (Türkiye)
Investigational Site Number : 7920005

Istanbul, 34010, Turkey (Türkiye)
Investigational Site Number : 7920006

Adana, 01120, Turkey (Türkiye)
Investigational Site Number : 8260001

Manchester, M20 4BX, United Kingdom
Investigational Site Number : 8260002

London, London, City of, SE5 9RL, United Kingdom
Investigational Site Number : 8260003

Leeds, LS9 7TF, United Kingdom
Investigational Site Number : 8260004

Newcastle upon Tyne, NE7 7DN, United Kingdom
Investigational Site Number : 8260006

Cardiff, Cardiff [Caerdydd Gb-crd], CF14 4XW, United Kingdom
Johns Hopkins Hospital- Site Number : 8400033

Baltimore, Maryland, 21287, United States
Karmanos Cancer Institute - Detroit- Site Number : 8400013

Detroit, Michigan, 48201, United States
Klinika hematoonkologie, Fakultni nemocnice Ostrava-Site Number : 2030001

Ostrava, 70852, Czechia
Northwestern University- Site Number : 8400017

Chicago, Illinois, 60611, United States
Nosokomeio Paidon I Agia Sofia-Site Number : 3000002

Athens, 115 27, Greece
Odense University Hospital-Investigational Site Number : 2080003

Odense, Funen, 5000, Denmark
Oncology Hematology Care - Kenwood- Site Number : 8400030

Cincinnati, Ohio, 45236, United States
Oregon Health and Science University- Site Number : 8400027

Portland, Oregon, 97239, United States
Rigshospitalet Copenhagen University Hospital-Investigational Site Number : 2080002

Copenhagen, Capital, 2100, Denmark
Sarah Cannon Research Institute Site Number : 8400003

Nashville, Tennessee, 37203, United States
St. David's South Austin Medical Center- Site Number : 8400002

Austin, Texas, 78704, United States
Texas Oncology - Dallas - Worth Street- Site Number : 8400010

Dallas, Texas, 75246, United States
Texas Transplant Institute - Methodist Hospital- Site Number : 8400037

San Antonio, Texas, 78229, United States
The Hope Clinic of Emory University- Site Number : 8400020

Decatur, Georgia, 30030, United States
The Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute- Site Number : 8400026

Columbus, Ohio, 43210, United States
UNC Children's Hospital- Site Number : 8400025

Chapel Hill, North Carolina, 27514, United States
UPMC Hillman Cancer Center- Site Number : 8400008

Pittsburgh, Pennsylvania, 15232, United States
UZ Gent-Investigational Site Number : 0560003

Ghent, 9000, Belgium
UZ Leuven-Investigational Site Number : 0560001

Leuven, Vlaams-Brabant, 3000, Belgium
University of Arkansas for Medical Sciences-Site Number : 8400019

Little Rock, Arkansas, 72205, United States
University of California San Francisco - Parnassus Heights- Site Number : 8400035

San Francisco, California, 94143, United States
University of Kentucky Chandler Medical Center- Site Number : 8400024

Lexington, Kentucky, 40536, United States
University of Virginia Comprehensive Cancer Center-Site Number : 8400031

Charlottesville, Virginia, 22903, United States
University of Wisconsin Carbone Cancer Center-Site Number : 8400029

Madison, Wisconsin, 53792, United States
Ustav hematologie a krevni transfuze-Site Number : 2030004

Prague, 128 00, Czechia

Conditions

Explore the condition pages connected to this study.

CHRONIC GRAFT VERSUS HOST DISEASE