Breakthrough trial tests promising new combo for Tough-to-Treat breast cancer

NCT ID NCT06380751

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new two-drug combination works better than current standard treatments for people with advanced breast cancer who have specific genetic mutations. It will involve about 500 adults whose cancer has spread and who have mutations in BRCA1, BRCA2, or PALB2 genes. Participants will receive either the experimental combination or one of two standard treatment approaches to compare how well they control cancer growth.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Study contacts

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Locations

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Gilbert, Arizona, 85234, United States
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Fountain Valley, California, 92708, United States
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Glendale, California, 91206, United States
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Los Angeles, California, 90089, United States
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Newport Beach, California, 92663, United States
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Aurora, Colorado, 80045, United States
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Grand Junction, Colorado, 81501, United States
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Hollywood, Florida, 33021, United States
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NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
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Orlando, Florida, 32806, United States
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Chicago, Illinois, 60611, United States
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Evanston, Illinois, 60201, United States
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Park Ridge, Illinois, 60068, United States
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Urbana, Illinois, 61801, United States
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Winfield, Illinois, 60190, United States
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Indianapolis, Indiana, 46227, United States
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Louisville, Kentucky, 40207, United States
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NOT_YET_RECRUITING

Baltimore, Maryland, 21201, United States
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Silver Spring, Maryland, 20902, United States
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Silver Spring, Maryland, 20904, United States
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Boston, Massachusetts, 02215, United States
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Dearborn, Michigan, 48126, United States
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Detroit, Michigan, 48202, United States
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Royal Oak, Michigan, 48073, United States
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NOT_YET_RECRUITING

Royal Oak, Michigan, 48073, United States
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Rochester, Minnesota, 55905, United States
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Springfield, Missouri, 65804, United States
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St Louis, Missouri, 63110, United States
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Camden, New Jersey, 08103, United States
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New Brunswick, New Jersey, 08901, United States
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Brooklyn, New York, 11220, United States
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Mineola, New York, 11501, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10016, United States
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New York, New York, 10028, United States
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New York, New York, 10065, United States
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Shirley, New York, 11967, United States
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Stony Brook, New York, 11790, United States
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The Bronx, New York, 10469, United States
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Westbury, New York, 11590, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15215, United States
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West Columbia, South Carolina, 29169, United States
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Chattanooga, Tennessee, 37404, United States
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Nashville, Tennessee, 37203, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77054, United States
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Norfolk, Virginia, 23502, United States
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Tacoma, Washington, 98405, United States
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Morgantown, West Virginia, 26506, United States
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Milwaukee, Wisconsin, 53215, United States
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Ciudad Autónoma Buenos Aires, 1125, Argentina
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Ciudad de Buenos Aires, 1015, Argentina
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Ciudad de Buenos Aires, C1280AEB, Argentina
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Córdoba, 5008, Argentina
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Rosario, S2000KZE, Argentina
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Salta, A4400EMI, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Darlinghurst, 2010, Australia
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Darlinghurst, 2139, Australia
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Malvern, 3144, Australia
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Melbourne, VIC 3000, Australia
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Graz, 8036, Austria
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NOT_YET_RECRUITING

Innsbruck, 6020, Austria
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Linz, 4010, Austria
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Vienna, 1090, Austria
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Cachoeira de Itapemirim, 29308-055, Brazil
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Curitiba, 80060-900, Brazil
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Fortaleza, 60336-045, Brazil
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Goiânia, 74000-000, Brazil
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Jaú, 17210-120, Brazil
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Porto Alegre, 91350-200, Brazil
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Ribeirão Preto, 14049-901, Brazil
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Salvador, 41253-190, Brazil
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São Paulo, 01509-900, Brazil
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São Paulo, 03102-002, Brazil
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Plovdiv, 4002, Bulgaria
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Sofia, 1527, Bulgaria
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Stara Zagora, 6003, Bulgaria
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Vratsa, 3000, Bulgaria
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NOT_YET_RECRUITING

Toronto, Ontario, M5G 2M9, Canada
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Greenfield Park, Quebec, J4V 2G9, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Saskatoon, Saskatchewan, S7N 4H4, Canada
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Toronto, M4N 3M5, Canada
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Providencia, 7500994, Chile
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Recoleta, 8420391, Chile
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Santiago, 8330034, Chile
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Talca, 3461341, Chile
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Viña del Mar, 2520000, Chile
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Beijing, 100044, China
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Bengbu, 233004, China
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Changchun, 130012, China
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Changchun, 130021, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400042, China
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Foshan, 528000, China
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Fuzhou, 350014, China
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Guangzhou, 510060, China
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Guangzhou, 510062, China
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Guangzhou, 510289, China
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Hangzhou, 310016, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230031, China
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Hohhot, 010017, China
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Jining, 272029, China
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Kunming, 650118, China
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Liuchow, 545006, China
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Luoyang, 471000, China
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Nanchang, 330006, China
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Nanchang, 330009, China
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Nanjing, 210029, China
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Shandong, 250117, China
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Shanghai, 200025, China
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Shanghai, 200120, China
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Shenyang, 110016, China
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Shijiazhuang, 050000, China
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Tianjin, 300000, China
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Weifang, 261000, China
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Wuhan, 430030, China
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Wuhan, 430040, China
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Wuhan, 430079, China
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Xi'an, 710006, China
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Xi'an, 710061, China
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Xiamen, 361003, China
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Xiangyang, 441000, China
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Xinxiang, 453100, China
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Zhengzhou, 450008, China
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Brno, 656 53, Czechia
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Hořovice, 26831, Czechia
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Hradec Králové, 500 05, Czechia
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Olomouc, 77900, Czechia
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Prague, 120 00, Czechia
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NOT_YET_RECRUITING

Prague, 180 00, Czechia
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Angers, 49100, France
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Besançon, 25030, France
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Lille, 59000, France
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Lyon, 69373, France
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Marseille, 13273, France
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Paris, 75005, France
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Rouen, 76021, France
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Saint-Herblain, 44805, France
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Toulouse, 31059, France
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Villejuif, 94805, France
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Aachen, 52074, Germany
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Augsburg, 86150, Germany
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Berlin, 13125, Germany
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Cologne, 50937, Germany
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Dessau, 06847, Germany
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Düsseldorf, 40225, Germany
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Erlangen, 91054, Germany
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Göttingen, DE-37099, Germany
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Hamburg, 20357, Germany
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Hanover, 30625, Germany
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Heidelberg, 69120, Germany
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Kiel, 24105, Germany
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Leipzig, 04103, Germany
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Ludwigsburg, 71640, Germany
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München, 81675, Germany
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Münster, 48149, Germany
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Hong Kong, 150001, Hong Kong
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NOT_YET_RECRUITING

Hong Kong, 999077, Hong Kong
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Budapest, 1082, Hungary
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Budapest, 1122, Hungary
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Budapest, 1145, Hungary
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NOT_YET_RECRUITING

Debrecen, 4032, Hungary
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Miskolc, 3526, Hungary
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Zalaegerszeg, 8900, Hungary
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Delhi, 110029, India
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Kolkata, 700160, India
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Lucknow, 226003, India
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NOT_YET_RECRUITING

Mumbai, 400012, India
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Mumbai, 400052, India
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Mysuru, 570017, India
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Nagpur, 440001, India
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Nashik, 422002, India
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New Delhi, 110085, India
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Surat, 396007, India
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Thiruvananthapuram, 695011, India
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Jerusalem, 9103102, Israel
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Jerusalem, 9112001, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 64239, Israel
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Milan, 20132, Italy
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Milan, 20141, Italy
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Modena, 41124, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Reggio Emilia, 422122, Italy
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Rome, 00168, Italy
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Rozzano, 20089, Italy
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Chiba, 260-8717, Japan
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Hidaka-shi, 350-1298, Japan
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Hirakata-shi, 573-1191, Japan
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Isehara-shi, 259-1193, Japan
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Kagoshima, 892-0833, Japan
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Kashiwa, 227-8577, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Kyoto, 606-8507, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 466-8560, Japan
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Nagoya, 467-8602, Japan
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Osaka, 541-8567, Japan
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Ota-shi, 373-8550, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-8574, Japan
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Shinagawa-ku, 142-8666, Japan
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Suita-shi, 565-0871, Japan
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Sunto-gun, 411-8777, Japan
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Takasaki-shi, 370-0829, Japan
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Tsu, 514-8507, Japan
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Yokohama, 241-8515, Japan
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NOT_YET_RECRUITING

Bandar Puncak Alam, 42300, Malaysia
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Johor Bahru, 81100, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 62250, Malaysia
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Malacca, 75000, Malaysia
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NOT_YET_RECRUITING

Bellavista, CALLAO 2, Peru
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Jesus Maria, Lima, LIMA 11, Peru
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NOT_YET_RECRUITING

Lima, 15036, Peru
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Lima, LIMA 29, Peru
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Biała Podlaska, 21-500, Poland
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Koszalin, 75-581, Poland
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Lodz, 93-338, Poland
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Lublin, 20-090, Poland
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Poznan, 60-569, Poland
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Poznan, 61-485, Poland
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Radom, 26-600, Poland
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Warsaw, 02-781, Poland
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Coimbra, 3000-075, Portugal
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Lisbon, 1099-023, Portugal
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Lisbon, 1998-018, Portugal
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Matosinhos Municipality, 4454-509, Portugal
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Porto, 4050-115, Portugal
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Vila Real, 5000-508, Portugal
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San Juan, 00918, Puerto Rico
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Daegu, 41404, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 02841, South Korea
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Seoul, 03080, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 3722, South Korea
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Seoul, 5505, South Korea
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NOT_YET_RECRUITING

A Coruña, 15009, Spain
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Barcelona, 08035, Spain
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Cáceres, 10003, Spain
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Granada, 18007, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Seville, 41013, Spain
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Valencia, 46006, Spain
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NOT_YET_RECRUITING

Zaragoza, 50009, Spain
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New Taipei City, 23561, Taiwan
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Taichung, Taiwan
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Tainan, 704, Taiwan
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Taipei, 100, Taiwan
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Taipei, 10449, Taiwan
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Taipei, 112, Taiwan
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Taoyuan District, 00333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10330, Thailand
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Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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NOT_YET_RECRUITING

Muang, 22000, Thailand
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Ratchathewi, 10400, Thailand
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Ratchathewi, 10400, Thailand
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Adapazarı, 54290, Turkey (Türkiye)
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Altındağ-Ankara, 06230, Turkey (Türkiye)
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Çankaya, 06680, Turkey (Türkiye)
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Istanbul, 34214, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Cambridge, CB2 2QQ, United Kingdom
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Guildford, GU2 7XX, United Kingdom
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London, SE1 9RT, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Oxford, OX3 7LE, United Kingdom
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Swansea, SA2 8QA, United Kingdom
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Taunton, TA1 5DA, United Kingdom
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Truro, TR1 3LJ, United Kingdom

Conditions

Explore the condition pages connected to this study.

ADVANCED BREAST CANCER