Major trial tests promising new treatment against aggressive breast cancer

NCT ID NCT04784715

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 study is comparing new drug combinations against standard treatment for people with advanced HER2-positive breast cancer that has spread. It's testing whether newer targeted drugs can help patients live longer without their cancer getting worse compared to current chemotherapy-based treatments. The trial also measures how treatments affect patients' quality of life and daily functioning.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Tucson, Arizona, 85711, United States
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Springdale, Arkansas, 72762, United States
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Glendale, California, 91204, United States
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Glendale, California, 91206, United States
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Longmont, Colorado, 80501, United States
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Miami, Florida, 33176, United States
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Palm Bay, Florida, 32909, United States
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Plantation, Florida, 33324, United States
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Atlanta, Georgia, 30318, United States
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Louisville, Kentucky, 40241, United States
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Silver Spring, Maryland, 20904, United States
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Boston, Massachusetts, 02215, United States
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Detroit, Michigan, 48202, United States
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Jackson, Mississippi, 39213, United States
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Las Vegas, Nevada, 89128, United States
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Summit, New Jersey, 07901, United States
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New York, New York, 10065, United States
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Shirley, New York, 11967, United States
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York, Pennsylvania, 17403, United States
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Germantown, Tennessee, 38138, United States
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Dallas, Texas, 75203, United States
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Dallas, Texas, 75246, United States
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Denton, Texas, 76201, United States
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Houston, Texas, 77090, United States
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San Antonio, Texas, 78240, United States
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Shenandoah, Texas, 77380, United States
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Tyler, Texas, 75702, United States
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Norfolk, Virginia, 23502, United States
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Roanoke, Virginia, 24014, United States
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Tacoma, Washington, 98405, United States
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Buenos Aires, C1125ABD, Argentina
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CABA, 1414, Argentina
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CABA, C1012AAR, Argentina
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Caba, C1118AAT, Argentina
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Capital Federal, C1417DTB, Argentina
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Cipolletti, 8234, Argentina
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Ciudad de Buenos Aires, 1280, Argentina
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La Plata, 1900, Argentina
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Mar del Plata, 7600, Argentina
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Rosario, S2000DEJ, Argentina
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Rosario, S2002KDS, Argentina
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San Salvador de Jujuy, 4600, Argentina
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Brussels, 1160, Belgium
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Brussels, 1200, Belgium
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Charleroi, 6060, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Florianópolis, 88034-000, Brazil
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Goiânia, 74000-000, Brazil
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Londrina, 86015-520, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90035-003, Brazil
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Ribeirão Preto, 14015-130, Brazil
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São Paulo, 03102-002, Brazil
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Sorocaba, 18030-005, Brazil
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Vitória, 29043-260, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Kitchener, Ontario, N2G 1G3, Canada
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Newmarket, Ontario, L3Y 2P9, Canada
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North York, Ontario, M2K 1E1, Canada
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Toronto, Ontario, M5G 1X5, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Montreal, Quebec, H3T 1M5, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Ste-Foy, Quebec, G1V 4G2, Canada
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Saskatoon, Saskatchewan, S7N 4H4, Canada
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Beijing, 100039, China
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Beijing, 100044, China
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Beijing, 100191, China
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Changchun, 130021, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400016, China
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Chongqing, 400030, China
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Dalian, 116011, China
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Guangzhou, 510060, China
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Guangzhou, 510080, China
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Guangzhou, 510120, China
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Hangzhou, 310003, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Kunming, 650118, China
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Nanchang, 330009, China
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Nanjing, 210008, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Qingdao, 266100, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Shenyang, 110001, China
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Shenzhen, 518036, China
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Tianjin, 300060, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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Xi'an, 710004, China
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Xi'an, 710061, China
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Yinchuan, 750004, China
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Zhengzhou, 450008, China
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Copenhagen O, 2100, Denmark
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Sønderborg, 6400, Denmark
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Vejle, 7100, Denmark
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Avignon, 84000, France
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Besançon, 25000, France
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Bordeaux, 33030, France
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Caen, 14076, France
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Le Mans, 72000, France
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Montpellier, 34070, France
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Montpellier, 34298, France
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Nice, 06189, France
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Paris, 75005, France
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Pierre-Bénite, 69495, France
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Rennes, 35042, France
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Saint-Cloud, 92210, France
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Saint-Herblain, 44805, France
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Toulouse, 31059, France
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Vandœuvre-lès-Nancy, 54519, France
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Berlin, 10117, Germany
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Dresden, 1307, Germany
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Erlangen, 91054, Germany
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Essen, 45136, Germany
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Frankfurt am Main, 60431, Germany
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Freiburg im Breisgau, 79110, Germany
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Hamburg, 20357, Germany
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Heidelberg, 69120, Germany
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Leipzig, 04103, Germany
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Münster, 48149, Germany
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Paderborn, 33161, Germany
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Budapest, 1062, Hungary
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Budapest, 1082, Hungary
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Budapest, 1115, Hungary
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Budapest, 1122, Hungary
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Budapest, 1145, Hungary
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Győr, 9024, Hungary
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Kecskemét, 6000, Hungary
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Nyíregyháza, 4400, Hungary
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Szolnok, 5000, Hungary
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Ahmedabad, 380060, India
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Bangalore, 560027, India
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Bengaluru, 560099, India
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Calicut, 673601, India
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Gūrgaon, 122001, India
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Mysuru, 570017, India
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Nashik, 422009, India
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Nashik, 422011, India
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New Delhi, 110075, India
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New Delhi, 110085, India
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Haifa, 31096, Israel
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Jerusalem, 9112001, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 5266202, Israel
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Tel Aviv, 64239, Israel
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Bergamo, 24127, Italy
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Candiolo, 10060, Italy
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Genova, 16132, Italy
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Livorno, 57100, Italy
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Milan, 20141, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Rozzano, 20089, Italy
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Udine, 33100, Italy
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Akashi-shi, 673-8558, Japan
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Aomori, 030-8553, Japan
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Bunkyō City, 113-8431, Japan
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Chiba, 260-8717, Japan
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Chūōku, 104-0045, Japan
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Fukushima, 960-1295, Japan
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Hidaka-shi, 350-1298, Japan
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Hiroshima, 730-8518, Japan
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Hiroshima, 734-8551, Japan
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Isehara-shi, 259-1193, Japan
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Kagoshima, 892-0833, Japan
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Kawasaki-shi, 216-8511, Japan
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Kobe, 650-0047, Japan
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Kōtoku, 135-8550, Japan
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Kurume-shi, 830-0011, Japan
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Kyoto, 606-8507, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 467-8602, Japan
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Niigata, 951-8566, Japan
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Nishinomiya-shi, 663-8501, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Ota-shi, 373-8550, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-8574, Japan
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Shinagawa-ku, 142-8666, Japan
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Shinjuku-ku, 160-0023, Japan
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Shinjuku-ku, 162-8655, Japan
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Shizuoka, 420-8527, Japan
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Tsu, 514-8507, Japan
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Yokohama, 241-8515, Japan
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Alc. Cuauhtémoc, 06700, Mexico
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Estado de México, 50080, Mexico
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Guadalajara, 44680, Mexico
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Metepec, 52140, Mexico
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Nuevo León, 66278, Mexico
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Veracruz, 91910, Mexico
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Arequipa, AREQUIPA01, Peru
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Lima, 15033, Peru
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Lima, 15036, Peru
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Lima, LIMA 29, Peru
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Lima, LIMA 34, Peru
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Baguio City, 2600, Philippines
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Cebu City, 6000, Philippines
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Davao City, 8000, Philippines
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Iloilo City, 5000, Philippines
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Manila, 1000, Philippines
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Quezon City, 1112, Philippines
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San Juan City, 1500, Philippines
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Bucharest, 011461, Romania
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Floreşti, 407280, Romania
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Moscow, 121205, Russia
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Moscow, 129090, Russia
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Moscow, 143442, Russia
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Saint Petersburg, 190020, Russia
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Saint Petersburg, 197758, Russia
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Yaroslavl, 150054, Russia
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Dammam, 31444, Saudi Arabia
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Jeddah, 22384, Saudi Arabia
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Jeddah, 23214, Saudi Arabia
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Riyadh, 11211, Saudi Arabia
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Riyadh, 11426, Saudi Arabia
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Cape Town, 7570, South Africa
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Cape Town, 7925, South Africa
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George, 6529, South Africa
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Johannesburg, 2193, South Africa
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Johannesburg, 2196, South Africa
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Port Elizabeth, 6045, South Africa
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Pretoria, 0081, South Africa
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Rondebosch, 7700, South Africa
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Soweto, 2013, South Africa
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Cheonan-si, 31151, South Korea
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Daegu, 41404, South Korea
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Goyang-si, 10408, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 08308, South Korea
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Alicante, 03010, Spain
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Barcelona, 08028, Spain
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Barcelona, 08036, Spain
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Barcelona, 8035, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Majadahonda, 28222, Spain
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Seville, 41009, Spain
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Gothenburg, 413 45, Sweden
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Örebro, 701 85, Sweden
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Stockholm, 118 83, Sweden
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Uppsala, 75185, Sweden
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Vaxjo, 35185, Sweden
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Taichung, 40443, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 100, Taiwan
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Taipei, 10449, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 235, Taiwan
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Taoyuan District, 333, Taiwan
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Adana, 01330, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Ankara, 06800, Turkey (Türkiye)
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Cordaleo, 35575, Turkey (Türkiye)
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Malatya, 44280, Turkey (Türkiye)
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Samsun, 55200, Turkey (Türkiye)
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Buckhurst Hill, IG9 5HX, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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Guildford, GU2 7WG, United Kingdom
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London, NW1 2PG, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Swansea, SA2 8QA, United Kingdom
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Taunton, TA1 5DA, United Kingdom

Conditions

Explore the condition pages connected to this study.

BREAST CANCER; HER2-POSITIVE; METASTATIC