New hope for advanced breast cancer patients in major global trial

NCT ID NCT04711252

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 trial is testing whether a new oral drug called camizestrant (AZD9833) works better than the current standard treatment when both are combined with palbociclib. The study involves 1,370 people with advanced ER-positive, HER2-negative breast cancer who haven't received any systemic treatment for their advanced disease. Researchers will compare how long patients live without their cancer getting worse between the two treatment groups.

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Contacts and locations

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Locations

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Mobile, Alabama, 36604, United States
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Springdale, Arkansas, 72762, United States
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Harbor City, California, 90710, United States
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Solvang, California, 93463, United States
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Lone Tree, Colorado, 80124, United States
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Fort Myers, Florida, 33901-8101, United States
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Jacksonville, Florida, 32256, United States
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West Palm Beach, Florida, 33401, United States
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Indianapolis, Indiana, 46256, United States
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Baton Rouge, Louisiana, 70809, United States
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Silver Spring, Maryland, 20904, United States
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Boston, Massachusetts, 02114, United States
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Detroit, Michigan, 48202, United States
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Hattiesburg, Mississippi, 39401, United States
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Omaha, Nebraska, 68130, United States
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Cincinnati, Ohio, 45219, United States
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Cincinnati, Ohio, 45267, United States
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Portland, Oregon, 97239, United States
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West Columbia, South Carolina, 29169, United States
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Sioux Falls, South Dakota, 57105, United States
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Chattanooga, Tennessee, 37404, United States
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Nashville, Tennessee, 37203, United States
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Austin, Texas, 78731, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77090, United States
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Tyler, Texas, 75702, United States
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Fairfax, Virginia, 22031, United States
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Kennewick, Washington, 99336, United States
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Renton, Washington, 98055, United States
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Morgantown, West Virginia, 26505, United States
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Feldkirch, 6807, Austria
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Salzburg, 5020, Austria
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Vienna, 1130, Austria
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Anderlecht, 1070, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Sint-Niklaas, 9100, Belgium
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4109, Bulgaria
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Shumen, 9700, Bulgaria
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Sofia, 1330, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1527, Bulgaria
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Edmonton, Alberta, T6G 1Z2, Canada
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Vancouver, British Columbia, V5Z 1H7, Canada
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Kitchener, Ontario, N2G 1G3, Canada
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London, Ontario, N6A 5W9, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, H3T 1E2, Canada
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Concepción, 4070196, Chile
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La Serena, 1720430, Chile
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Santiago, 7630370, Chile
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Santiago, 8241479, Chile
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Baoding, 071000, China
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Beijing, 100039, China
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Beijing, 100142, China
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Beijing, China
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Bengbu, 233060, China
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Changchun, 130000, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610042, China
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Chongqing, 400042, China
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Dalian, 116011, China
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Guangzhou, 510060, China
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Guangzhou, 510100, China
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Guiyang, 550004, China
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Haikou, 570311, China
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Hangzhou, 310020, China
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Hangzhou, 310022, China
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Hefei, 230031, China
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Jinan, 250117, China
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Lanzhou, 730000, China
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Linyi, 276000, China
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Nanchang, 330009, China
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Nanjing, 210008, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Shenyang, 110001, China
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Tianjin, 300060, China
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Wuhan, 430000, China
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Wuhan, 430022, China
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Xi'an, 710061, China
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Zhengzhou, 450008, China
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Hořovice, 268 01, Czechia
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Hradec Králové, 500 05, Czechia
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Nový Jičín, 741 01, Czechia
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Prague, 100 34, Czechia
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Prague, 140 00, Czechia
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Prague, 150 06, Czechia
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Besançon, 25030, France
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Bordeaux, 33030, France
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Brest, 29609, France
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Caen, 14076, France
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Dijon, 21079, France
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Le Mans, 72000, France
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Lille, 59000, France
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Montpellier, 34070, France
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Pierre-Bénite, 69495, France
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Plerin SUR MER, 22190, France
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Saint-Cloud, 92210, France
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Vandœuvre-lès-Nancy, 54000, France
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Villejuif, 94805, France
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Berlin, 13125, Germany
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Dessau-RoBlau, 06847, Germany
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Essen, 45136, Germany
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Freiburg im Breisgau, 79110, Germany
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Mönchengladbach, 41061, Germany
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München, 81675, Germany
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Münster, 48145, Germany
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Regensburg, 93053, Germany
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Velbert, 42551, Germany
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Budapest, 1062, Hungary
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Budapest, 1088, Hungary
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Budapest, 1122, Hungary
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Győr, 9024, Hungary
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Miskolc, 3526, Hungary
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Nyíregyháza, 4400, Hungary
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Szekszárd, 7100, Hungary
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Zalaegerszeg, 8900, Hungary
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Ahmedabad, 380060, India
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Calicut, 673601, India
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Delhi, 110085, India
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Faridabad, 121001, India
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Gūrgaon, 122001, India
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Karamsad, 388325, India
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Kolkata, 700160, India
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Madurai, 625107, India
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Nagpur, 440001, India
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Nashik, 422009, India
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Nashik, 422011, India
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New Delhi, 11029, India
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Bergamo, 24127, Italy
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Florence, 50139, Italy
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Milan, 20141, Italy
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Modena, 41124, Italy
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Naples, 80131, Italy
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Novara, 28100, Italy
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Padua, 35128, Italy
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Parma, 43100, Italy
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Prato, 59100, Italy
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Roma, 00168, Italy
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Roma, 161, Italy
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Rozzano, 20089, Italy
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Chiba, 260-8717, Japan
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Chūōku, 104-0045, Japan
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Chūōku, 862-8655, Japan
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Hidaka-shi, 350-1298, Japan
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Hirakata-shi, 573-1191, Japan
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Isehara-shi, 259-1193, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Kurashiki Shi, 701 0192, Japan
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Kurume-shi, 830-0013, Japan
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Kyoto, 606-8507, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 467-8602, Japan
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Nishinomiya-shi, 663-8501, Japan
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Osaka, 540-0006, Japan
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Osaka, 541-8567, Japan
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Ota-shi, 373-8550, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-8574, Japan
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Shimotsuke-shi, 329-0498, Japan
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Shinagawa-ku, 142-8666, Japan
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Shinjuku-ku, 162-8655, Japan
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Suita-shi, 565-0871, Japan
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Takasaki-shi, 370-0829, Japan
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Tsu, 514-8507, Japan
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Tsukuba, 305-8576, Japan
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Yokohama, 241-8515, Japan
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George Town, 10450, Malaysia
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Johor Bahru, 81100, Malaysia
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Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 62250, Malaysia
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Kuching, 93586, Malaysia
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Del. Cuauhtemoc, 06700, Mexico
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Estado de México, 50080, Mexico
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La Paz, 23040, Mexico
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Mexico City, 0 3100, Mexico
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Monterrey, 64710, Mexico
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Puebla City, 72424, Mexico
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Drammen, 3004, Norway
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Oslo, N-0379, Norway
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Gdynia, 81-519, Poland
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Konin, 62-500, Poland
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Koszalin, 75-581, Poland
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Lodz, 90-302, Poland
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Lublin, 20-090, Poland
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Olsztyn, 10-513, Poland
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Poznan, 60-192, Poland
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Braga, 4710, Portugal
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Guimarães, 4835-044, Portugal
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Lisbon, 1400-038, Portugal
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Lisbon, 1500-650, Portugal
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Lisbon, 1998-018, Portugal
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Loures, 2674-514, Portugal
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Porto, 4099-001, Portugal
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Porto, 4200-319, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Kaluga, 248007, Russia
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Kislino Village, Ryshkovsky Ru, 305524, Russia
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Moscow, 111123, Russia
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Moscow, 115478, Russia
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Moscow, 117997, Russia
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Moscow, 121467, Russia
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Saint Petersburg, 190103, Russia
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Saint Petersburg, 195067, Russia
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Saint Petersburg, 196603, Russia
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Saint Petersburg, 197758, Russia
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Banská Bystrica, 974 01, Slovakia
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Bratislava, 81250, Slovakia
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Bratislava, 833 01, Slovakia
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Prešov, 081 81, Slovakia
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Trenčín, 91171, Slovakia
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Busan, 49201, South Korea
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Daegu, 41404, South Korea
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Goyang-si, 10408, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08908, Spain
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Barcelona, 8035, Spain
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Jaén, 23007, Spain
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Lleida, 25198, Spain
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Madrid, 28040, Spain
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Madrid, 28046, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Santander, 39008, Spain
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Seville, 41013, Spain
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Valencia, 46015, Spain
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Liestal, CH- 4410, Switzerland
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Zurich, 8008, Switzerland
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Kaohsiung City, 82445, Taiwan
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Kaohsiung City, Taiwan
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Taichung, 40443, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10048, Taiwan
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Taipei, 104, Taiwan
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Taipei, 110, Taiwan
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Taipei, 235, Taiwan
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Taoyuan District, 333, Taiwan
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Adana, 01120, Turkey (Türkiye)
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06230, Turkey (Türkiye)
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Ankara, 06340, Turkey (Türkiye)
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Ankara, 6100, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Izmir, 35620, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Cambridge, CB2 2QQ, United Kingdom
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Colchester, CO4 5JL, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Surrey, GU2 7XX, United Kingdom

Conditions

Explore the condition pages connected to this study.

ER-POSITIVE HER2-NEGATIVE BREAST CANCER