Scientists test aggressive new cocktail against rare brain cancer

NCT ID NCT04609046

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This early-stage trial is testing the safety and best dose of a new four-drug combination for primary central nervous system (CNS) lymphoma, a rare cancer of the brain or spinal cord. The study combines standard chemotherapy drugs with two newer agents—one that helps the immune system attack cancer and another that may cut off the tumor's blood supply. Researchers want to see if using two of these drugs as long-term 'maintenance' therapy can help keep the cancer in remission longer after initial treatment.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States

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Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

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Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

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Hickman Cancer Center
ACTIVE_NOT_RECRUITING

Adrian, Michigan, 49221, United States
Huntsman Cancer Institute/University of Utah
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
Iowa Lutheran Hospital
SUSPENDED

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States

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LSU Health Baton Rouge-North Clinic
SUSPENDED

Baton Rouge, Louisiana, 70805, United States
MaineHealth Cancer Care and IV Therapy - South Portland
RECRUITING

South Portland, Maine, 04106, United States

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MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

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MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

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Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

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Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

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Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

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Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

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Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

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Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States

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Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States

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Methodist West Hospital
SUSPENDED

West Des Moines, Iowa, 50266-7700, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

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NYP/Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States

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North Shore University Hospital
RECRUITING

Manhasset, New York, 11030, United States

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Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States

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Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

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Our Lady of the Lake Physician Group
SUSPENDED

Baton Rouge, Louisiana, 70808, United States
Overlook Hospital
RECRUITING

Summit, New Jersey, 07902, United States

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Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States

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Saint Anthony Regional Hospital
RECRUITING

Carroll, Iowa, 51401, United States

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Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

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Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

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Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

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State University of New York Upstate Medical University
ACTIVE_NOT_RECRUITING

Syracuse, New York, 13210, United States
Toledo Clinic Cancer Centers-Monroe
ACTIVE_NOT_RECRUITING

Monroe, Michigan, 48162, United States
Toledo Clinic Cancer Centers-Toledo
ACTIVE_NOT_RECRUITING

Toledo, Ohio, 43623, United States
UCSF Medical Center-Parnassus
RECRUITING

San Francisco, California, 94143, United States

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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States

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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States

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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States

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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States

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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States

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UI Healthcare Mission Cancer and Blood - Fort Dodge
SUSPENDED

Fort Dodge, Iowa, 50501, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States

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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

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UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States

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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States

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UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

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University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
RECRUITING

North Miami, Florida, 33181, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

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Conditions

Explore the condition pages connected to this study.

PRIMARY DIFFUSE LARGE B-CELL LYMPHOMA OF THE CENTRAL NERVOUS SYSTEM