New hope for tough bladder cancers: experimental drug challenges standard chemo

NCT ID NCT07106762

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This trial is testing whether a new drug combination called izalontamab brengitecan works better than standard chemotherapy for people with advanced bladder cancer that has stopped responding to immunotherapy. About 470 participants will receive either the experimental drug or chemotherapy to see which helps people live longer without their cancer getting worse. The study aims to find a better treatment option for patients who have few choices left.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

A.O.U.C. Policlinico di Bari
RECRUITING

Bari, Apulia, 70124, Italy

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AZ Maria Middelares
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium

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Akershus Universitetssykehus
RECRUITING

Lørenskog, Akershus, 1478, Norway

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Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia

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Azienda Ospedaliera Universitaria Federico II
RECRUITING

Naples, 80131, Italy

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CHU de Bordeaux Hop St ANDRE
RECRUITING

Bordeaux, Aquitaine, 33075, France

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Cantonal Hospital St.Gallen
RECRUITING

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

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Caritas-Krankenhaus St. Josef
RECRUITING

Regensburg, Bavaria, 93053, Germany

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Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
RECRUITING

Liège, 4000, Belgium

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Centrul de Oncologie "Sfântul Nectarie"
RECRUITING

Craiova, Dolj, 200542, Romania

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Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

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Cleveland Clinic - Hillcrest Hospital
RECRUITING

Mayfield Heights, Ohio, 44124, United States

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Fairview Hospital
RECRUITING

Cleveland, Ohio, 44111, United States

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Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy

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GenesisCare North Shore
RECRUITING

St Leonards, New South Wales, 2065, Australia

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Groupe hospitalier Paris saint Joseph
RECRUITING

Paris, Île-de-France Region, 75014, France

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Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain

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Hospital Infanta Cristina
RECRUITING

Badajoz, 06006, Spain

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Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain

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Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain

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Hospital Universitario Reina Sofia
RECRUITING

Córdoba, 14004, Spain

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Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain

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Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, Catalunya [Cataluña], 08041, Spain

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Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States

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Institutul Regional de Oncologie
RECRUITING

Iași, 700483, Romania

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Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States

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Istituto Nazionale Tumori Regina Elena
RECRUITING

Rome, Roma, 00144, Italy

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Istituto Oncologico Veneto IRCCS
RECRUITING

Castelfranco Veneto, Veneto, 31033, Italy

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Kantonsspital Graubünden
RECRUITING

Chur, 7000, Switzerland

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Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

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Klinikum Nürnberg Nord
RECRUITING

Nuremberg, Bavaria, 90419, Germany

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Krankenhaus Nordwest GmbH
RECRUITING

Frankfurt, 60488, Germany

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Local Institution - 0001
NOT_YET_RECRUITING

Villejuif, Val-de-Marne, 94800, France

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Local Institution - 0002
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Saint-Herblain, Loire-Atlantique, 44805, France

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Local Institution - 0003
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Clermont-Ferrand, Puy-de-Dôme, 63011, France

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Local Institution - 0005
WITHDRAWN

Marseille, Provence-Alpes-Côte d'Azur Region, 13273, France
Local Institution - 0006
NOT_YET_RECRUITING

Lyon Cedex08, Auvergne-Rhône-Alpes, 69373, France

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Local Institution - 0008
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Paris, 75015, France

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Local Institution - 0009
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Nice, Alpes-Maritimes, 06189, France

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Local Institution - 0017
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Montreal, Quebec, H4A 3J1, Canada

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Local Institution - 0020
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Edmonton, Alberta, T6G 1Z2, Canada

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Local Institution - 0023
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

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Local Institution - 0024
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ABB, Buenos Aires F.D., C1199ABB, Argentina

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Local Institution - 0025
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Córdoba, 5000, Argentina

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Local Institution - 0026
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Buenos Aires, Buenos Aires F.D., C1419AHN, Argentina

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Local Institution - 0027
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Mendoza, M5500AYB, Argentina

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Local Institution - 0028
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CABA, Buenos Aires, CP1280AEB, Argentina

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Local Institution - 0031
NOT_YET_RECRUITING

Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

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Local Institution - 0033
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Amsterdam, North Holland, 1066 CX, Netherlands

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Local Institution - 0036
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Breda, North Brabant, 4818 CK, Netherlands

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Local Institution - 0040
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Strasbourg, Alsace, 67098, France

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Local Institution - 0041
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Prague, Praha 5, 150 06, Czechia

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Local Institution - 0042
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Shanghai, Shanghai Municipality, 200032, China

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Local Institution - 0046
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Nanjing, Jiangsu, 210009, China

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Local Institution - 0048
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Fuzhou, Fujian, 350001, China

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Local Institution - 0050
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Beijing, Beijing Municipality, 100034, China

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Local Institution - 0051
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Guangzhou, Guangdong, 510060, China

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Local Institution - 0052
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Tianjin, Tianjin Municipality, 300060, China

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Local Institution - 0053
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Wenzhou, Zhejiang, 325000, China

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Local Institution - 0056
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Xiamen, Fujian, 361003, China

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Local Institution - 0059
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Changsha, Hunan, 410013, China

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Local Institution - 0060
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Fuzhou, Fujian, 350005, China

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Local Institution - 0064
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Zhengzhou, 450008, China

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Local Institution - 0066
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Cluj-Napoca, 400015, Romania

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Local Institution - 0084
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Nashville, Tennessee, 37232, United States

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Local Institution - 0094
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Haifa, Northern District, 3109601, Israel

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Local Institution - 0095
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Jerusalem, Jerusalem, 9112001, Israel

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Local Institution - 0096
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Petah Tikva, Central District, 4941492, Israel

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Local Institution - 0098
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Parma, 43126, Italy

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Local Institution - 0099
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Genoa, Liguria, 16132, Italy

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Local Institution - 0100
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Pisa, Tuscany, 56126, Italy

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Local Institution - 0106
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Ẕerifin, Central District, 70300, Israel

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Local Institution - 0114
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Nantong, Jiangsu, 226361, China

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Local Institution - 0115
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Brno, Brno-město, 656 53, Czechia

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Local Institution - 0121
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

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Local Institution - 0124
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São Paulo, 01452-000, Brazil

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Local Institution - 0129
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Salvador, Estado de Bahia, 41253-190, Brazil

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Local Institution - 0130
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Rio de Janeiro, 22451-100, Brazil

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Local Institution - 0131
NOT_YET_RECRUITING

Vienna, Vienna, 1160, Austria

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Local Institution - 0139
NOT_YET_RECRUITING

Sacramento, California, 95817, United States

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Local Institution - 0141
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States

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Local Institution - 0146
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Hradec Králové, Hradec Králové, 500 05, Czechia

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Local Institution - 0154
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Berlin, 10117, Germany

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Local Institution - 0155
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Innsbruck, Tyrol, 6020, Austria

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Local Institution - 0156
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Qingdao, Shandong, 266003, China

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Local Institution - 0157
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Hangzhou, Zhejiang, 310022, China

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Local Institution - 0161
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Columbus, Ohio, 43210, United States

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Local Institution - 0162
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Fullerton, California, 92835, United States

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Local Institution - 0163
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Sacramento, California, 95816, United States

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Local Institution - 0167
NOT_YET_RECRUITING

Gilbert, Arizona, 85234, United States

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Local Institution - 0169
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Koto-ku, Tokyo, 135-8550, Japan

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Local Institution - 0171
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Bunkyo-ku, Tokyo, 1138603, Japan

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Local Institution - 0179
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Toyoma, Toyama, 930-0194, Japan

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Local Institution - 0183
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Kawasaki, Kanagawa, 216-8511, Japan

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Local Institution - 0186
NOT_YET_RECRUITING

Nashville, Tennessee, 37203, United States

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Local Institution - 0187
NOT_YET_RECRUITING

Austin, Texas, 78705, United States

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Local Institution - 0188
NOT_YET_RECRUITING

Norfolk, Virginia, 23502, United States

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Local Institution - 0193
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Lexington, Kentucky, 40536, United States

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Local Institution - 0195
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States

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Local Institution - 0199
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Valencia, Valenciana, Comunitat, 46009, Spain

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Local Institution - 0200
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Seattle, Washington, 98101, United States

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Local Institution - 0201
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Wuhan, Hubei, 430030, China

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Local Institution - 0205
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Yantai, Shandong, 264000, China

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Local Institution - 0206
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China

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Local Institution - 0223
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Suresnes, Hauts-de-Seine, 92151, France

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Local Institution - 0224
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100091, China

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Local Institution - 0226
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Guangzhou, Guangdong, 510280, China

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Local Institution - 0227
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Tianjin, Tianjin Municipality, 300070, China

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Local Institution - 0230
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Sheffield, S10 2SJ, United Kingdom

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Local Institution - 0232
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Baltimore, Maryland, 21287, United States

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Local Institution - 0234
NOT_YET_RECRUITING

Gothenburg, Västra Götalands Län [se-14], 413 45, Sweden

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Local Institution - 0235
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Solna, Stockholms Län [se-01], 171 64, Sweden

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Local Institution - 0236
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Dublin, D24 NR0A, Ireland

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Local Institution - 0238
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Cork, T12 DC4A, Ireland

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Local Institution - 0241
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Malmo, 205 02, Sweden

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Local Institution - 0243
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Glasgow, Glasgow City, G12 0YN, United Kingdom

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Local Institution - 0245
WITHDRAWN

Dillon, Colorado, 80435, United States
Local Institution - 0247
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Miami, Florida, 33176, United States

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Local Institution - 0248
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Buffalo, New York, 14203, United States

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Local Institution - 0249
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Abilene, Texas, 79606, United States

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Local Institution - 0250
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Washington D.C., District of Columbia, 20016, United States

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Local Institution - 0251
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San Francisco, California, 94115, United States

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Local Institution - 0252
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Palo Alto, California, 94304, United States

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Local Institution - 0253
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St. George, Utah, 84790, United States

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Local Institution - 0254
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Santa Rosa, California, 95403, United States

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Local Institution - 0255
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Seattle, Washington, 98109, United States

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Local Institution - 0258
NOT_YET_RECRUITING

Brest, Finistère, 29200, France

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Macquarie University
RECRUITING

Macquarie University, New South Wales, 2109, Australia

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Marienhospital Herne
RECRUITING

Herne, 44625, Germany

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Medizinische Hochschule Hannover
RECRUITING

Hanover, Lower Saxony, 30625, Germany

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Medizinische Universität Wien
RECRUITING

Vienna, Vienna, 1090, Austria

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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NCT
RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany

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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
RECRUITING

Nanjing, Jiangsu, 210000, China

Contact Phone: •••-•••-••••
Ospedale Regionale Bellinzona e Valli
RECRUITING

Bellinzona, Canton Ticino, 6500, Switzerland

Contact Phone: •••-•••-••••
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy

Contact Phone: •••-•••-••••
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact Phone: •••-•••-••••
Royal Marsden Hospital (Sutton)
RECRUITING

London, Sutton, SM2 5PT, United Kingdom

Contact Phone: •••-•••-••••
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China

Contact Phone: •••-•••-••••
Shaw Cancer Center
RECRUITING

Edwards, Colorado, 81632, United States

Contact Phone: •••-•••-••••
St Bartholomew's Hospital
RECRUITING

London, London, City of, EC1A 7BE, United Kingdom

Contact Phone: •••-•••-••••
Studienpraxis Urologie
RECRUITING

Nürtingen, Baden-Wurttemberg, 72622, Germany

Contact Phone: •••-•••-••••
Sykehuset i Vestfold
RECRUITING

Tønsberg, Vestfold, 3103, Norway

Contact Phone: •••-•••-••••
Sykehuset Østfold Kalnes
RECRUITING

Sarpsborg, Østfold fylke, 1714, Norway

Contact Phone: •••-•••-••••
TUM Klinikum
RECRUITING

Munich, Bavaria, 81675, Germany

Contact Phone: •••-•••-••••
The First Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510120, China

Contact Phone: •••-•••-••••
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada

Contact Phone: •••-•••-••••
UZ Gent
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium

Contact Phone: •••-•••-••••
Universitaetsklinikum Duesseldorf
RECRUITING

Düsseldorf, 40225, Germany

Contact Phone: •••-•••-••••
Universitaetsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany

Contact Phone: •••-•••-••••
Universitaetsklinikum Schleswig-Holstein Campus Kiel
RECRUITING

Kiel, Schleswig-Holstein, 24105, Germany

Contact Phone: •••-•••-••••
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89081, Germany

Contact Phone: •••-•••-••••
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22903, United States

Contact Phone: •••-•••-••••
UniversitätsSpital Zürich
RECRUITING

Zurich, 8091, Switzerland

Contact Phone: •••-•••-••••
Universitätsklinikum Jena
RECRUITING

Jena, Thuringia, 07747, Germany

Contact Phone: •••-•••-••••
West China Hospital, Sichuan University
RECRUITING

Chengdu, Sichuan, 610066, China

Contact Phone: •••-•••-••••
ZAS Augustinus
RECRUITING

Wilrijk, Antwerpen, 2610, Belgium

Contact Phone: •••-•••-••••

Conditions

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UROTHELIAL CANCER