New hope for tough bladder cancers: experimental drug challenges standard chemo

NCT ID NCT07106762

Summary

This trial is testing whether a new drug combination called izalontamab brengitecan works better than standard chemotherapy for people with advanced bladder cancer that has stopped responding to immunotherapy. About 470 participants will receive either the experimental drug or chemotherapy to see which helps people live longer without their cancer getting worse. The study aims to find a better treatment option for patients who have few choices left.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • A.O.U.C. Policlinico di Bari

    RECRUITING

    Bari, Apulia, 70124, Italy

    Contact Phone: •••-•••-••••

  • AZ Maria Middelares

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

    Contact Phone: •••-•••-••••

  • Akershus Universitetssykehus

    RECRUITING

    Lørenskog, Akershus, 1478, Norway

    Contact Phone: •••-•••-••••

  • Austin Health

    RECRUITING

    Heidelberg, Victoria, 3084, Australia

    Contact Phone: •••-•••-••••

  • Azienda Ospedaliera Universitaria Federico II

    RECRUITING

    Naples, 80131, Italy

    Contact Phone: •••-•••-••••

  • CHU de Bordeaux Hop St ANDRE

    RECRUITING

    Bordeaux, Aquitaine, 33075, France

    Contact Phone: •••-•••-••••

  • Cantonal Hospital St.Gallen

    RECRUITING

    Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

    Contact Phone: •••-•••-••••

  • Caritas-Krankenhaus St. Josef

    RECRUITING

    Regensburg, Bavaria, 93053, Germany

    Contact Phone: •••-•••-••••

  • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

    RECRUITING

    Liège, 4000, Belgium

    Contact Phone: •••-•••-••••

  • Centrul de Oncologie "Sfântul Nectarie"

    RECRUITING

    Craiova, Dolj, 200542, Romania

    Contact Phone: •••-•••-••••

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Phone: •••-•••-••••

  • Cleveland Clinic - Hillcrest Hospital

    RECRUITING

    Mayfield Heights, Ohio, 44124, United States

    Contact Phone: •••-•••-••••

  • Fairview Hospital

    RECRUITING

    Cleveland, Ohio, 44111, United States

    Contact Phone: •••-•••-••••

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    RECRUITING

    Milan, 20133, Italy

    Contact Phone: •••-•••-••••

  • GenesisCare North Shore

    RECRUITING

    St Leonards, New South Wales, 2065, Australia

    Contact Phone: •••-•••-••••

  • Groupe hospitalier Paris saint Joseph

    RECRUITING

    Paris, Île-de-France Region, 75014, France

    Contact Phone: •••-•••-••••

  • Hospital Clinico San Carlos

    RECRUITING

    Madrid, 28040, Spain

    Contact Phone: •••-•••-••••

  • Hospital Infanta Cristina

    RECRUITING

    Badajoz, 06006, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Marqués de Valdecilla

    RECRUITING

    Santander, Cantabria, 39008, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, Madrid, Comunidad de, 28034, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Reina Sofia

    RECRUITING

    Córdoba, 14004, Spain

    Contact Phone: •••-•••-••••

  • Hospital Universitario Virgen Del Rocio

    RECRUITING

    Seville, 41013, Spain

    Contact Phone: •••-•••-••••

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, Catalunya [Cataluña], 08041, Spain

    Contact Phone: •••-•••-••••

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

    Contact Phone: •••-•••-••••

  • Institutul Regional de Oncologie

    RECRUITING

    Iași, 700483, Romania

    Contact Phone: •••-•••-••••

  • Intermountain Medical Center

    RECRUITING

    Murray, Utah, 84107, United States

    Contact Phone: •••-•••-••••

  • Istituto Nazionale Tumori Regina Elena

    RECRUITING

    Rome, Roma, 00144, Italy

    Contact Phone: •••-•••-••••

  • Istituto Oncologico Veneto IRCCS

    RECRUITING

    Castelfranco Veneto, Veneto, 31033, Italy

    Contact Phone: •••-•••-••••

  • Kantonsspital Graubünden

    RECRUITING

    Chur, 7000, Switzerland

    Contact Phone: •••-•••-••••

  • Karmanos Cancer Institute

    RECRUITING

    Detroit, Michigan, 48201, United States

    Contact Phone: •••-•••-••••

  • Klinikum Nürnberg Nord

    RECRUITING

    Nuremberg, Bavaria, 90419, Germany

    Contact Phone: •••-•••-••••

  • Krankenhaus Nordwest GmbH

    RECRUITING

    Frankfurt, 60488, Germany

    Contact Phone: •••-•••-••••

  • Local Institution - 0001

    NOT_YET_RECRUITING

    Villejuif, Val-de-Marne, 94800, France

    Contact

  • Local Institution - 0002

    NOT_YET_RECRUITING

    Saint-Herblain, Loire-Atlantique, 44805, France

    Contact

  • Local Institution - 0003

    NOT_YET_RECRUITING

    Clermont-Ferrand, Puy-de-Dôme, 63011, France

    Contact

  • Local Institution - 0005

    WITHDRAWN

    Marseille, Provence-Alpes-Côte d'Azur Region, 13273, France

  • Local Institution - 0006

    NOT_YET_RECRUITING

    Lyon Cedex08, Auvergne-Rhône-Alpes, 69373, France

    Contact

  • Local Institution - 0008

    NOT_YET_RECRUITING

    Paris, 75015, France

    Contact

  • Local Institution - 0009

    NOT_YET_RECRUITING

    Nice, Alpes-Maritimes, 06189, France

    Contact

  • Local Institution - 0017

    NOT_YET_RECRUITING

    Montreal, Quebec, H4A 3J1, Canada

    Contact

  • Local Institution - 0020

    NOT_YET_RECRUITING

    Edmonton, Alberta, T6G 1Z2, Canada

    Contact

  • Local Institution - 0023

    NOT_YET_RECRUITING

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

    Contact

  • Local Institution - 0024

    NOT_YET_RECRUITING

    ABB, Buenos Aires F.D., C1199ABB, Argentina

    Contact

  • Local Institution - 0025

    NOT_YET_RECRUITING

    Córdoba, 5000, Argentina

    Contact

  • Local Institution - 0026

    NOT_YET_RECRUITING

    Buenos Aires, Buenos Aires F.D., C1419AHN, Argentina

    Contact

  • Local Institution - 0027

    NOT_YET_RECRUITING

    Mendoza, M5500AYB, Argentina

    Contact

  • Local Institution - 0028

    NOT_YET_RECRUITING

    CABA, Buenos Aires, CP1280AEB, Argentina

    Contact

  • Local Institution - 0031

    NOT_YET_RECRUITING

    Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

    Contact

  • Local Institution - 0033

    NOT_YET_RECRUITING

    Amsterdam, North Holland, 1066 CX, Netherlands

    Contact

  • Local Institution - 0036

    NOT_YET_RECRUITING

    Breda, North Brabant, 4818 CK, Netherlands

    Contact

  • Local Institution - 0040

    NOT_YET_RECRUITING

    Strasbourg, Alsace, 67098, France

    Contact

  • Local Institution - 0041

    NOT_YET_RECRUITING

    Prague, Praha 5, 150 06, Czechia

    Contact

  • Local Institution - 0042

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

    Contact

  • Local Institution - 0046

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, 210009, China

    Contact

  • Local Institution - 0048

    NOT_YET_RECRUITING

    Fuzhou, Fujian, 350001, China

    Contact

  • Local Institution - 0050

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100034, China

    Contact

  • Local Institution - 0051

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, 510060, China

    Contact

  • Local Institution - 0052

    NOT_YET_RECRUITING

    Tianjin, Tianjin Municipality, 300060, China

    Contact

  • Local Institution - 0053

    NOT_YET_RECRUITING

    Wenzhou, Zhejiang, 325000, China

    Contact

  • Local Institution - 0056

    NOT_YET_RECRUITING

    Xiamen, Fujian, 361003, China

    Contact

  • Local Institution - 0059

    NOT_YET_RECRUITING

    Changsha, Hunan, 410013, China

    Contact

  • Local Institution - 0060

    NOT_YET_RECRUITING

    Fuzhou, Fujian, 350005, China

    Contact

  • Local Institution - 0064

    NOT_YET_RECRUITING

    Zhengzhou, 450008, China

    Contact

  • Local Institution - 0066

    NOT_YET_RECRUITING

    Cluj-Napoca, 400015, Romania

    Contact

  • Local Institution - 0084

    NOT_YET_RECRUITING

    Nashville, Tennessee, 37232, United States

    Contact

  • Local Institution - 0094

    NOT_YET_RECRUITING

    Haifa, Northern District, 3109601, Israel

    Contact

  • Local Institution - 0095

    NOT_YET_RECRUITING

    Jerusalem, Jerusalem, 9112001, Israel

    Contact

  • Local Institution - 0096

    NOT_YET_RECRUITING

    Petah Tikva, Central District, 4941492, Israel

    Contact

  • Local Institution - 0098

    NOT_YET_RECRUITING

    Parma, 43126, Italy

    Contact

  • Local Institution - 0099

    NOT_YET_RECRUITING

    Genoa, Liguria, 16132, Italy

    Contact

  • Local Institution - 0100

    NOT_YET_RECRUITING

    Pisa, Tuscany, 56126, Italy

    Contact

  • Local Institution - 0106

    NOT_YET_RECRUITING

    Ẕerifin, Central District, 70300, Israel

    Contact

  • Local Institution - 0114

    NOT_YET_RECRUITING

    Nantong, Jiangsu, 226361, China

    Contact

  • Local Institution - 0115

    NOT_YET_RECRUITING

    Brno, Brno-město, 656 53, Czechia

    Contact

  • Local Institution - 0121

    NOT_YET_RECRUITING

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

    Contact

  • Local Institution - 0124

    NOT_YET_RECRUITING

    São Paulo, 01452-000, Brazil

    Contact

  • Local Institution - 0129

    NOT_YET_RECRUITING

    Salvador, Estado de Bahia, 41253-190, Brazil

    Contact

  • Local Institution - 0130

    NOT_YET_RECRUITING

    Rio de Janeiro, 22451-100, Brazil

    Contact

  • Local Institution - 0131

    NOT_YET_RECRUITING

    Vienna, Vienna, 1160, Austria

    Contact

  • Local Institution - 0139

    NOT_YET_RECRUITING

    Sacramento, California, 95817, United States

    Contact

  • Local Institution - 0141

    NOT_YET_RECRUITING

    Portland, Oregon, 97239, United States

    Contact

  • Local Institution - 0146

    NOT_YET_RECRUITING

    Hradec Králové, Hradec Králové, 500 05, Czechia

    Contact

  • Local Institution - 0154

    NOT_YET_RECRUITING

    Berlin, 10117, Germany

    Contact

  • Local Institution - 0155

    NOT_YET_RECRUITING

    Innsbruck, Tyrol, 6020, Austria

    Contact

  • Local Institution - 0156

    NOT_YET_RECRUITING

    Qingdao, Shandong, 266003, China

    Contact

  • Local Institution - 0157

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, 310022, China

    Contact

  • Local Institution - 0161

    NOT_YET_RECRUITING

    Columbus, Ohio, 43210, United States

    Contact

  • Local Institution - 0162

    NOT_YET_RECRUITING

    Fullerton, California, 92835, United States

    Contact

  • Local Institution - 0163

    NOT_YET_RECRUITING

    Sacramento, California, 95816, United States

    Contact

  • Local Institution - 0167

    NOT_YET_RECRUITING

    Gilbert, Arizona, 85234, United States

    Contact

  • Local Institution - 0169

    NOT_YET_RECRUITING

    Koto-ku, Tokyo, 135-8550, Japan

    Contact

  • Local Institution - 0171

    NOT_YET_RECRUITING

    Bunkyo-ku, Tokyo, 1138603, Japan

    Contact

  • Local Institution - 0179

    NOT_YET_RECRUITING

    Toyoma, Toyama, 930-0194, Japan

    Contact

  • Local Institution - 0183

    NOT_YET_RECRUITING

    Kawasaki, Kanagawa, 216-8511, Japan

    Contact

  • Local Institution - 0186

    NOT_YET_RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact

  • Local Institution - 0187

    NOT_YET_RECRUITING

    Austin, Texas, 78705, United States

    Contact

  • Local Institution - 0188

    NOT_YET_RECRUITING

    Norfolk, Virginia, 23502, United States

    Contact

  • Local Institution - 0193

    NOT_YET_RECRUITING

    Lexington, Kentucky, 40536, United States

    Contact

  • Local Institution - 0195

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact

  • Local Institution - 0199

    NOT_YET_RECRUITING

    Valencia, Valenciana, Comunitat, 46009, Spain

    Contact

  • Local Institution - 0200

    NOT_YET_RECRUITING

    Seattle, Washington, 98101, United States

    Contact

  • Local Institution - 0201

    NOT_YET_RECRUITING

    Wuhan, Hubei, 430030, China

    Contact

  • Local Institution - 0205

    NOT_YET_RECRUITING

    Yantai, Shandong, 264000, China

    Contact

  • Local Institution - 0206

    NOT_YET_RECRUITING

    Nanchang, Jiangxi, 330006, China

    Contact

  • Local Institution - 0223

    NOT_YET_RECRUITING

    Suresnes, Hauts-de-Seine, 92151, France

    Contact

  • Local Institution - 0224

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100091, China

    Contact

  • Local Institution - 0226

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, 510280, China

    Contact

  • Local Institution - 0227

    NOT_YET_RECRUITING

    Tianjin, Tianjin Municipality, 300070, China

    Contact

  • Local Institution - 0230

    NOT_YET_RECRUITING

    Sheffield, S10 2SJ, United Kingdom

    Contact

  • Local Institution - 0232

    NOT_YET_RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

  • Local Institution - 0234

    NOT_YET_RECRUITING

    Gothenburg, Västra Götalands Län [se-14], 413 45, Sweden

    Contact

  • Local Institution - 0235

    NOT_YET_RECRUITING

    Solna, Stockholms Län [se-01], 171 64, Sweden

    Contact

  • Local Institution - 0236

    NOT_YET_RECRUITING

    Dublin, D24 NR0A, Ireland

    Contact

  • Local Institution - 0238

    NOT_YET_RECRUITING

    Cork, T12 DC4A, Ireland

    Contact

  • Local Institution - 0241

    NOT_YET_RECRUITING

    Malmo, 205 02, Sweden

    Contact

  • Local Institution - 0243

    NOT_YET_RECRUITING

    Glasgow, Glasgow City, G12 0YN, United Kingdom

    Contact

  • Local Institution - 0245

    WITHDRAWN

    Dillon, Colorado, 80435, United States

  • Local Institution - 0247

    NOT_YET_RECRUITING

    Miami, Florida, 33176, United States

    Contact

  • Local Institution - 0248

    NOT_YET_RECRUITING

    Buffalo, New York, 14203, United States

    Contact

  • Local Institution - 0249

    NOT_YET_RECRUITING

    Abilene, Texas, 79606, United States

    Contact

  • Local Institution - 0250

    NOT_YET_RECRUITING

    Washington D.C., District of Columbia, 20016, United States

    Contact

  • Local Institution - 0251

    NOT_YET_RECRUITING

    San Francisco, California, 94115, United States

    Contact

  • Local Institution - 0252

    NOT_YET_RECRUITING

    Palo Alto, California, 94304, United States

    Contact

  • Local Institution - 0253

    NOT_YET_RECRUITING

    St. George, Utah, 84790, United States

    Contact

  • Local Institution - 0254

    NOT_YET_RECRUITING

    Santa Rosa, California, 95403, United States

    Contact

  • Local Institution - 0255

    NOT_YET_RECRUITING

    Seattle, Washington, 98109, United States

    Contact

  • Local Institution - 0258

    NOT_YET_RECRUITING

    Brest, Finistère, 29200, France

    Contact

  • Macquarie University

    RECRUITING

    Macquarie University, New South Wales, 2109, Australia

    Contact Phone: •••-•••-••••

  • Marienhospital Herne

    RECRUITING

    Herne, 44625, Germany

    Contact Phone: •••-•••-••••

  • Medizinische Hochschule Hannover

    RECRUITING

    Hanover, Lower Saxony, 30625, Germany

    Contact Phone: •••-•••-••••

  • Medizinische Universität Wien

    RECRUITING

    Vienna, Vienna, 1090, Austria

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact Phone: •••-•••-••••

  • NCT

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

    Contact Phone: •••-•••-••••

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

    RECRUITING

    Nanjing, Jiangsu, 210000, China

    Contact Phone: •••-•••-••••

  • Ospedale Regionale Bellinzona e Valli

    RECRUITING

    Bellinzona, Canton Ticino, 6500, Switzerland

    Contact Phone: •••-•••-••••

  • Ospedale San Raffaele

    RECRUITING

    Milan, 20132, Italy

    Contact Phone: •••-•••-••••

  • Princess Margaret Cancer Centre

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

    Contact Phone: •••-•••-••••

  • Royal Marsden Hospital (Sutton)

    RECRUITING

    London, Sutton, SM2 5PT, United Kingdom

    Contact Phone: •••-•••-••••

  • Shandong Cancer Hospital

    RECRUITING

    Jinan, Shandong, 250117, China

    Contact Phone: •••-•••-••••

  • Shaw Cancer Center

    RECRUITING

    Edwards, Colorado, 81632, United States

    Contact Phone: •••-•••-••••

  • St Bartholomew's Hospital

    RECRUITING

    London, London, City of, EC1A 7BE, United Kingdom

    Contact Phone: •••-•••-••••

  • Studienpraxis Urologie

    RECRUITING

    Nürtingen, Baden-Wurttemberg, 72622, Germany

    Contact Phone: •••-•••-••••

  • Sykehuset i Vestfold

    RECRUITING

    Tønsberg, Vestfold, 3103, Norway

    Contact Phone: •••-•••-••••

  • Sykehuset Østfold Kalnes

    RECRUITING

    Sarpsborg, Østfold fylke, 1714, Norway

    Contact Phone: •••-•••-••••

  • TUM Klinikum

    RECRUITING

    Munich, Bavaria, 81675, Germany

    Contact Phone: •••-•••-••••

  • The First Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, Guangdong, 510120, China

    Contact Phone: •••-•••-••••

  • The Ottawa Hospital Cancer Centre

    RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

    Contact Phone: •••-•••-••••

  • UZ Gent

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Duesseldorf

    RECRUITING

    Düsseldorf, 40225, Germany

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Hamburg-Eppendorf

    RECRUITING

    Hamburg, 20246, Germany

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel

    RECRUITING

    Kiel, Schleswig-Holstein, 24105, Germany

    Contact Phone: •••-•••-••••

  • Universitaetsklinikum Ulm

    RECRUITING

    Ulm, 89081, Germany

    Contact Phone: •••-•••-••••

  • University of Virginia Health System

    RECRUITING

    Charlottesville, Virginia, 22903, United States

    Contact Phone: •••-•••-••••

  • UniversitätsSpital Zürich

    RECRUITING

    Zurich, 8091, Switzerland

    Contact Phone: •••-•••-••••

  • Universitätsklinikum Jena

    RECRUITING

    Jena, Thuringia, 07747, Germany

    Contact Phone: •••-•••-••••

  • West China Hospital, Sichuan University

    RECRUITING

    Chengdu, Sichuan, 610066, China

    Contact Phone: •••-•••-••••

  • ZAS Augustinus

    RECRUITING

    Wilrijk, Antwerpen, 2610, Belgium

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.