New Risk-Guided approach aims to boost cure rates for childhood leukemia
NCT ID NCT03020030
First seen Jan 27, 2026 · Last updated May 15, 2026 · Updated 17 times
Summary
This study is for children and teens newly diagnosed with acute lymphoblastic leukemia (ALL), a blood cancer that is fatal without treatment. The trial uses an updated set of risk factors to tailor how strong the chemotherapy should be, aiming to give each child the best chance for cure. It also tests a new way of dosing a key chemotherapy drug, pegaspargase, by checking drug levels in the blood and adjusting the dose as needed. About 560 participants will be followed to see if this personalized approach improves cure rates and reduces side effects.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Centre Hospitalier U. de Quebec
Québec, Quebec, Canada
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Columbia University Medical Center, Morgan Stanley Children's Hospital of New York-Presbyterian
New York, New York, 10032, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Hasbro Children's Hospital / Rhode Island Hospital
Providence, Rhode Island, 02903, United States
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Hospital Sainte Justine, University of Montreal
Montreal, Quebec, Canada
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
Conditions
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