New hope for tough childhood cancers: scientists test Triple-Threat drug combo
NCT ID NCT01711554
Summary
This early-stage study is testing a combination of three drugs—lenalidomide, dinutuximab, and isotretinoin—in children and young adults whose neuroblastoma has returned or hasn't responded to standard treatments. The main goal is to find the safest dose of lenalidomide when given with the other two drugs and to understand the side effects. Researchers also want to see if this combination can help the body's immune system fight the cancer and if it shows any signs of shrinking tumors.
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Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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C S Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
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Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, 30329, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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UCSF Medical Center-Parnassus
San Francisco, California, 94143, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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University of Chicago Comer Children's Hospital
Chicago, Illinois, 60637, United States
Conditions
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