New hope for kids with tough cancer: major trial tests antibody cocktail

NCT ID NCT00026312

Summary

This large, completed Phase 3 trial tested whether adding a combination of immunotherapy drugs to standard chemotherapy improved outcomes for children with high-risk neuroblastoma. The study involved 1,449 young patients who had already undergone intensive treatment, including a stem cell transplant. Researchers compared standard care to a regimen that added an antibody drug (dinutuximab) and immune-boosting agents to see if it better prevented the cancer from coming back.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AdventHealth Orlando

    Orlando, Florida, 32803, United States

  • Advocate Children's Hospital-Oak Lawn

    Oak Lawn, Illinois, 60453, United States

  • Albany Medical Center

    Albany, New York, 12208, United States

  • Alberta Children's Hospital

    Calgary, Alberta, T3B 6A8, Canada

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada, 89135, United States

  • Arkansas Children's Hospital

    Little Rock, Arkansas, 72202-3591, United States

  • Arnold Palmer Hospital for Children

    Orlando, Florida, 32806, United States

  • Ascension Saint Vincent Indianapolis Hospital

    Indianapolis, Indiana, 46260, United States

  • Augusta University Medical Center

    Augusta, Georgia, 30912, United States

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina, 29605, United States

  • Banner University Medical Center - Tucson

    Tucson, Arizona, 85719, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Baystate Medical Center

    Springfield, Massachusetts, 01199, United States

  • Blank Children's Hospital

    Des Moines, Iowa, 50309, United States

  • British Columbia Children's Hospital

    Vancouver, British Columbia, V6H 3V4, Canada

  • Bronson Methodist Hospital

    Kalamazoo, Michigan, 49007, United States

  • Broward Health Medical Center

    Fort Lauderdale, Florida, 33316, United States

  • C S Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    Québec, G1V 4G2, Canada

  • CancerCare Manitoba

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Cardinal Glennon Children's Medical Center

    St Louis, Missouri, 63104, United States

  • Carilion Children's

    Roanoke, Virginia, 24014, United States

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina, 28203, United States

  • Centre Hospitalier Universitaire Sainte-Justine

    Montreal, Quebec, H3T 1C5, Canada

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital

    London, Ontario, N6A 5W9, Canada

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital Medical Center of Akron

    Akron, Ohio, 44308, United States

  • Children's Hospital New Orleans

    New Orleans, Louisiana, 70118, United States

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska, 68114, United States

  • Children's Hospital of Alabama

    Birmingham, Alabama, 35233, United States

  • Children's Hospital of Eastern Ontario

    Ottawa, Ontario, K1H 8L1, Canada

  • Children's Hospital of Orange County

    Orange, California, 92868, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's Hospital of The King's Daughters

    Norfolk, Virginia, 23507, United States

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota, 55404, United States

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri, 64108, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Christchurch Hospital

    Christchurch, 8011, New Zealand

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Connecticut Children's Medical Center

    Hartford, Connecticut, 06106, United States

  • Cook Children's Medical Center

    Fort Worth, Texas, 76104, United States

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan, 49503, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Dayton Children's Hospital

    Dayton, Ohio, 45404, United States

  • Dell Children's Medical Center of Central Texas

    Austin, Texas, 78723, United States

  • Driscoll Children's Hospital

    Corpus Christi, Texas, 78411, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee, 37916, United States

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822, United States

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida, 33908, United States

  • Greenville Cancer Treatment Center

    Greenville, South Carolina, 29605, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Henry Ford Health Saint John Hospital

    Detroit, Michigan, 48236, United States

  • Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • IWK Health Centre

    Halifax, Nova Scotia, B3K 6R8, Canada

  • Inova Fairfax Hospital

    Falls Church, Virginia, 22042, United States

  • Janeway Child Health Centre

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • John Hunter Children's Hospital

    Hunter Regional Mail Centre, New South Wales, 2310, Australia

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida, 33701, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • Kaiser Permanente Downey Medical Center

    Downey, California, 90242, United States

  • Kaiser Permanente-Oakland

    Oakland, California, 94611, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York, 10016, United States

  • Lee Memorial Health System

    Fort Myers, Florida, 33901, United States

  • Legacy Emanuel Children's Hospital

    Portland, Oregon, 97227, United States

  • Legacy Emanuel Hospital and Health Center

    Portland, Oregon, 97227, United States

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania, 18017, United States

  • Loma Linda University Medical Center

    Loma Linda, California, 92354, United States

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California, 94304, United States

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois, 60611, United States

  • Maine Children's Cancer Program

    Scarborough, Maine, 04074, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • McMaster Children's Hospital at Hamilton Health Sciences

    Hamilton, Ontario, L8N 3Z5, Canada

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Medical City Dallas Hospital

    Dallas, Texas, 75230, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Health University Medical Center

    Savannah, Georgia, 31404, United States

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida, 33021, United States

  • Mercy Children's Hospital

    Toledo, Ohio, 43608, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas, 78229, United States

  • Miami Cancer Institute

    Miami, Florida, 33176, United States

  • Michigan State University

    East Lansing, Michigan, 48823, United States

  • Miller Children's and Women's Hospital Long Beach

    Long Beach, California, 90806, United States

  • Mission Hospital

    Asheville, North Carolina, 28801, United States

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • NYU Langone Hospital - Long Island

    Mineola, New York, 11501, United States

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Naval Medical Center - Portsmouth

    Portsmouth, Virginia, 23708-2197, United States

  • Nemours Children's Clinic - Orlando

    Orlando, Florida, 32806, United States

  • Nemours Children's Clinic - Pensacola

    Pensacola, Florida, 32504, United States

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida, 32207, United States

  • Nemours Children's Hospital

    Orlando, Florida, 32827, United States

  • Nevada Cancer Research Foundation NCORP

    Las Vegas, Nevada, 89120, United States

  • New York Medical College

    Valhalla, New York, 10595, United States

  • Newark Beth Israel Medical Center

    Newark, New Jersey, 07112, United States

  • Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

  • Norton Children's Hospital

    Louisville, Kentucky, 40202, United States

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina, 28204, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Orlando Health Cancer Institute

    Orlando, Florida, 32806, United States

  • Overlook Hospital

    Summit, New Jersey, 07902, United States

  • Penn State Children's Hospital

    Hershey, Pennsylvania, 17033, United States

  • Phoenix Childrens Hospital

    Phoenix, Arizona, 85016, United States

  • Primary Children's Hospital

    Salt Lake City, Utah, 84113, United States

  • Princess Margaret Hospital for Children

    Perth, Western Australia, 6008, Australia

  • Prisma Health Richland Hospital

    Columbia, South Carolina, 29203, United States

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio, 43606, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508, United States

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington, 99204, United States

  • Queensland Children's Hospital

    South Brisbane, Queensland, 4101, Australia

  • Rady Children's Hospital - San Diego

    San Diego, California, 92123, United States

  • Rainbow Babies and Childrens Hospital

    Cleveland, Ohio, 44106, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, 46202, United States

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    Denver, Colorado, 80218, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Royal Brisbane and Women's Hospital

    Herston, Queensland, 4029, Australia

  • Royal Children's Hospital

    Parkville, Victoria, 3052, Australia

  • Royal Children's Hospital-Brisbane

    Herston, Queensland, 4029, Australia

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    New Brunswick, New Jersey, 08903, United States

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania, 19134, United States

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida, 33607, United States

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

  • Saint Jude Midwest Affiliate

    Peoria, Illinois, 61637, United States

  • Saint Mary's Medical Center

    West Palm Beach, Florida, 33407, United States

  • Saint Peter's University Hospital

    New Brunswick, New Jersey, 08901, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • San Jorge Children's Hospital

    San Juan, 00912, Puerto Rico

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • Sinai Hospital of Baltimore

    Baltimore, Maryland, 21215, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • Starship Children's Hospital

    Grafton, Auckland, 1145, New Zealand

  • State University of New York Upstate Medical University

    Syracuse, New York, 13210, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • Sydney Children's Hospital

    Randwick, New South Wales, 2031, Australia

  • T C Thompson Children's Hospital

    Chattanooga, Tennessee, 37403, United States

  • The Children's Hospital at Westmead

    Westmead, New South Wales, 2145, Australia

  • The Montreal Children's Hospital of the MUHC

    Montreal, Quebec, H3H 1P3, Canada

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    New Hyde Park, New York, 11040, United States

  • Tripler Army Medical Center

    Honolulu, Hawaii, 96859, United States

  • Tufts Children's Hospital

    Boston, Massachusetts, 02111, United States

  • UCSF Benioff Children's Hospital Oakland

    Oakland, California, 94609, United States

  • UCSF Medical Center-Mission Bay

    San Francisco, California, 94158, United States

  • UCSF Medical Center-Parnassus

    San Francisco, California, 94143, United States

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637, United States

  • University of Hawaii Cancer Center

    Honolulu, Hawaii, 96813, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa, 52242, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of Missouri Children's Hospital

    Columbia, Missouri, 65212, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Vermont and State Agricultural College

    Burlington, Vermont, 05405, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Valley Children's Hospital

    Madera, California, 93636, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20889-5600, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • West Virginia University Healthcare

    Morgantown, West Virginia, 26506, United States

  • Women's and Children's Hospital-Adelaide

    North Adelaide, South Australia, 5006, Australia

  • Yale University

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.