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Can a cocktail of nerve blocks replace opioids after heart bypass?

NCT ID NCT07794527

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests whether combining several regional nerve blocks can improve pain control and recovery in people undergoing off-pump coronary artery bypass surgery. Participants receive either a combination of local anesthetic injections or a placebo, and researchers measure how quickly they can be taken off the ventilator. The goal is to see if this approach can reduce opioid use and speed up recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Combination of regional nerve blocks using bupivacaine (parasternal, rectus sheath, and femoral blocks)
What this could lead to
If effective, this approach could reduce opioid use, shorten time on a ventilator, and speed up recovery after heart bypass surgery.
What could go wrong
This is a small early-stage trial, and the blocks may not provide enough pain relief or could carry risks like bleeding or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * o Scheduled for elective off-pump coronary artery bypass graft (OPCAB) surgery via median sternotomy * American Society of Anesthesiologists (ASA) physical status III - IV * Ability to provide informed consent Exclusion Criteria: * o Emergency or redo cardiac surgery * On-pump CABG or concomitant valve or aortic procedures * Known allergy to local anesthetics or study drugs * Coagulopathy or ongoing anticoagulant therapy contraindicating regional block * Preoperative chronic opioid use or opioid dependency * Neurologic or psychiatric conditions interfering with pain assessment * Infection at the block injection site * Severe hepatic or renal impairment * Body mass index (BMI) \> 40 kg/m² * Inability to understand or cooperate with pain scoring or postoperative care.

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Conditions

The condition(s) this trial relates to.

myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic heart disease (IHD) Off-pump coronary artery bypass Regional block for pain control

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ain shams university hospitals

    RECRUITING

    Cairo, Egypt

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