Hope for High-Risk families: drug aims to stop lung scarring before it starts

NCT ID NCT07201922

Recruiting now Prevention Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This study tests a drug called nerandomilast in 80 people aged 40+ who have early lung changes and a family history of pulmonary fibrosis. Participants take either the drug or a placebo twice daily for up to 3 years. Doctors monitor lung function and scans to see if the drug slows worsening of lung scarring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nerandomilast
What this could lead to: If it works, this could point toward a way to prevent pulmonary fibrosis in people at high risk due to family history.
What could go wrong: This is an early exploratory trial with only 80 participants, so results may not apply to everyone. The drug may not slow lung changes and could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

inherited interstitial lung disease interstitial lung disease pulmonary fibrosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FAMILIAL PULMONARY FIBROSIS INTERSTITIAL LUNG ABNORMALITIES INTERSTITIAL LUNG DISEASES

Contacts and locations

Locations

Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliera Universitaria di Padova
RECRUITING

Padova, 35128, Italy
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CEDIC - Centro de Investigacion Clinica
RECRUITING

CABA, C1060ABN, Argentina
Centro de Investigaciones Metabolicas (CINME)
RECRUITING

Buenos Aires, C1056ABJ, Argentina
Centro de Investigación Clinica Belgrano
RECRUITING

CABA, 1425, Argentina
Clinical Research Specialists LLC - Kissimmee
RECRUITING

Kissimmee, Florida, 34746, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Consultorios Médicos del Buen Ayre
RECRUITING

Capital Federal, 1425, Argentina
Erasmus Medisch Centrum
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
HOP Bichat
RECRUITING

Paris, 75877, France
HOP Pontchaillou
RECRUITING

Rennes, 35033, France
Hamamatsu University Hospital
RECRUITING

Shizuoka, Hamamatsu, 431-3192, Japan
Hospital Italiano de Buenos Aires
RECRUITING

CABA, 1181, Argentina
Hospital Universitari de Bellvitge
RECRUITING

L'Hospitalet Del Llobregat, 08907, Spain
Hospital Universitario De La Princesa
NOT_YET_RECRUITING

Madrid, 28006, Spain
Hospital Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hospital de Galdakao
RECRUITING

Galdakao, 48960, Spain
Hôpital Larrey - CHU de Toulouse
RECRUITING

Toulouse, 31059, France
Hôpital Louis Pradel
RECRUITING

Bron, 69677, France
INS Coeur Poumon
RECRUITING

Lille, 59037, France
IRCCS MultiMedica
RECRUITING

Milan, 20123, Italy
Kanagawa Cardiovascular and Respiratory Center
RECRUITING

Kanagawa, Yokohama, 236-0051, Japan
Krankenhaus Bethanien gGmbH
RECRUITING

Solingen, 42699, Germany
Lung Research Queensland
RECRUITING

Chermside, Queensland, 4032, Australia
Lungenfachklinik Immenhausen
RECRUITING

Immenhausen, 34376, Germany
McGill University Health Centre (MUHC)
NOT_YET_RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Medical University of South Carolina
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
National Center for Global Health and Medicine
RECRUITING

Tokyo, Shinjuku-ku, 162-8655, Japan
National Hospital Organization Kinki-Chuo Chest Medical Center
RECRUITING

Osaka, Sakai, 591-8555, Japan
Royal Brompton Hospital
RECRUITING

London, SW3 6HP, United Kingdom
Royal Devon and Exeter Hospital, Wonford
RECRUITING

Exeter, EX2 5DW, United Kingdom
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH
NOT_YET_RECRUITING

Essen, 45239, Germany
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Severance Hospital
RECRUITING

Seoul, 03722, South Korea
St. Antonius Ziekenhuis
RECRUITING

Nieuwegein, 3435 CM, Netherlands
St. Joseph's Healthcare Hamilton
NOT_YET_RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Prince Charles Hospital
RECRUITING

Chermside, Queensland, 4032, Australia
Tosei General Hospital
RECRUITING

Aichi, Seto, 489-8642, Japan
Tsuboi Hospital
RECRUITING

Fukushima, Koriyama, 963-0197, Japan
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University of California Los Angeles
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
University of Colorado Denver
RECRUITING

Aurora, Colorado, 80045, United States
University of Kansas Medical Center
NOT_YET_RECRUITING

Kansas City, Kansas, 66160, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37204, United States
Virginia Commonwealth University
NOT_YET_RECRUITING

Richmond, Virginia, 23219, United States
Weill Cornell Medicine-New York-60569
RECRUITING

New York, New York, 10065, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.