Hope for High-Risk families: drug aims to stop lung scarring before it starts
NCT ID NCT07201922
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a drug called nerandomilast in 80 people aged 40+ who have early lung changes and a family history of pulmonary fibrosis. Participants take either the drug or a placebo twice daily for up to 3 years. Doctors monitor lung function and scans to see if the drug slows worsening of lung scarring.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nerandomilast
What this could lead to
If it works, this could point toward a way to prevent pulmonary fibrosis in people at high risk due to family history.
What could go wrong
This is an early exploratory trial with only 80 participants, so results may not apply to everyone. The drug may not slow lung changes and could cause side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Azienda Ospedaliera Universitaria di Padova
NOT_YET_RECRUITINGPadova, 35128, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CEDIC - Centro de Investigacion Clinica
RECRUITINGCABA, C1060ABN, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centro de Investigaciones Metabolicas (CINME)
NOT_YET_RECRUITINGBuenos Aires, C1056ABJ, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centro de Investigación Clinica Belgrano
RECRUITINGCABA, 1425, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Clinical Research Specialists LLC - Kissimmee
RECRUITINGKissimmee, Florida, 34746, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cliniques Universitaires Saint-Luc
RECRUITINGBrussels, 1200, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Consultorios Médicos del Buen Ayre
RECRUITINGCapital Federal, 1425, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Erasmus Medisch Centrum
NOT_YET_RECRUITINGRotterdam, 3015 GD, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITINGRoma, 00168, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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HOP Bichat
RECRUITINGParis, 75877, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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HOP Pontchaillou
RECRUITINGRennes, 35033, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hamamatsu University Hospital
RECRUITINGShizuoka, Hamamatsu, 431-3192, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Italiano de Buenos Aires
NOT_YET_RECRUITINGCABA, 1181, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari de Bellvitge
NOT_YET_RECRUITINGL'Hospitalet Del Llobregat, 08907, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario De La Princesa
NOT_YET_RECRUITINGMadrid, 28006, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Virgen del Rocío
RECRUITINGSeville, 41013, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital de Galdakao
RECRUITINGGaldakao, 48960, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Larrey - CHU de Toulouse
NOT_YET_RECRUITINGToulouse, 31059, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Louis Pradel
RECRUITINGBron, 69677, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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INS Coeur Poumon
RECRUITINGLille, 59037, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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IRCCS MultiMedica
NOT_YET_RECRUITINGMilan, 20123, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kanagawa Cardiovascular and Respiratory Center
RECRUITINGKanagawa, Yokohama, 236-0051, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Krankenhaus Bethanien gGmbH
NOT_YET_RECRUITINGSolingen, 42699, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Lung Research Queensland
RECRUITINGChermside, Queensland, 4032, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Lungenfachklinik Immenhausen
NOT_YET_RECRUITINGImmenhausen, 34376, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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McGill University Health Centre (MUHC)
NOT_YET_RECRUITINGMontreal, Quebec, H4A 3J1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medical University of South Carolina
NOT_YET_RECRUITINGCharleston, South Carolina, 29425, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medizinische Hochschule Hannover
RECRUITINGHanover, 30625, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Center for Global Health and Medicine
RECRUITINGTokyo, Shinjuku-ku, 162-8655, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Hospital Organization Kinki-Chuo Chest Medical Center
NOT_YET_RECRUITINGOsaka, Sakai, 591-8555, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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QEII Health Sciences Centre
NOT_YET_RECRUITINGHalifax, Nova Scotia, B3H 3A7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Brompton Hospital
RECRUITINGLondon, SW3 6HP, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Devon and Exeter Hospital, Wonford
RECRUITINGExeter, EX2 5DW, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Prince Alfred Hospital
NOT_YET_RECRUITINGCamperdown, New South Wales, 2050, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH
NOT_YET_RECRUITINGEssen, 45239, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Samsung Medical Center
NOT_YET_RECRUITINGSeoul, 06351, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Severance Hospital
RECRUITINGSeoul, 03722, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Antonius Ziekenhuis
RECRUITINGNieuwegein, 3435 CM, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Joseph's Healthcare Hamilton
NOT_YET_RECRUITINGHamilton, Ontario, L8N 4A6, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Alfred Hospital
RECRUITINGMelbourne, Victoria, 3004, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Prince Charles Hospital
RECRUITINGChermside, Queensland, 4032, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tosei General Hospital
NOT_YET_RECRUITINGAichi, Seto, 489-8642, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tsuboi Hospital
RECRUITINGFukushima, Koriyama, 963-0197, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UZ Leuven
RECRUITINGLeuven, 3000, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California Los Angeles
NOT_YET_RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Colorado Denver
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Medical Center
NOT_YET_RECRUITINGKansas City, Kansas, 66160, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
NOT_YET_RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University Medical Center
NOT_YET_RECRUITINGNashville, Tennessee, 37204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Commonwealth University
NOT_YET_RECRUITINGRichmond, Virginia, 23219, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Weill Cornell Medicine-New York-60569
NOT_YET_RECRUITINGNew York, New York, 10021, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••