New combo therapy aims to shrink rectal tumors before surgery

NCT ID NCT07381400

First seen Feb 02, 2026 · Last updated May 17, 2026 · Updated 19 times

Summary

This study tests whether adding an immunotherapy drug (Serplulimab) to standard chemotherapy before surgery can help people with a certain type of advanced rectal cancer. About 128 adults with non-spreading rectal cancer will be split into two groups: one gets the drug combo, the other gets chemo alone. The goal is to see if the combo leads to more tumors completely disappearing by the time of surgery.

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