New pill could tame involuntary twitching in mental health patients

NCT ID NCT07365462

Recruiting now Symptom relief Sponsor: Neurocrine Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental drug, NBI-1065890, to see if it can reduce involuntary movements in adults with tardive dyskinesia, a condition often caused by long-term use of certain mental health medications. About 100 participants with schizophrenia, bipolar disorder, or depression will receive either the drug or a placebo for 8 weeks. The main goal is to measure changes in movement severity using a standard rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NBI-1065890
What this could lead to: If it works, this could provide a new option to reduce uncontrolled movements in people with tardive dyskinesia.
What could go wrong: This is an early Phase 2 trial with only 100 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

tardive dyskinesia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TARDIVE DYSKINESIA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Neurocrine Clinical Site
RECRUITING

Bryant, Arkansas, 72022, United States
Neurocrine Clinical Site
RECRUITING

Chino, California, 91710, United States
Neurocrine Clinical Site
RECRUITING

Fountain Valley, California, 92708, United States
Neurocrine Clinical Site
RECRUITING

Huntington Beach, California, 92648, United States
Neurocrine Clinical Site
RECRUITING

Long Beach, California, 90807, United States
Neurocrine Clinical Site
RECRUITING

Temecula, California, 92591, United States
Neurocrine Clinical Site
RECRUITING

Torrance, California, 90501, United States
Neurocrine Clinical Site
RECRUITING

Boca Raton, Florida, 33486, United States
Neurocrine Clinical Site
RECRUITING

Bonita Springs, Florida, 34134, United States
Neurocrine Clinical Site
RECRUITING

Hialeah, Florida, 33012, United States
Neurocrine Clinical Site
RECRUITING

Miami, Florida, 33176, United States
Neurocrine Clinical Site
RECRUITING

Orange City, Florida, 32763, United States
Neurocrine Clinical Site
RECRUITING

Tampa, Florida, 33629, United States
Neurocrine Clinical Site
RECRUITING

Marietta, Georgia, 30060, United States
Neurocrine Clinical Site
RECRUITING

Lincoln, Nebraska, 68526, United States
Neurocrine Clinical Site
RECRUITING

Beachwood, Ohio, 44122, United States
Neurocrine Clinical Site
RECRUITING

Fort Worth, Texas, 76104, United States
Neurocrine Clinical Site
RECRUITING

Houston, Texas, 77030, United States

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