New drug targets Hard-to-Treat lung cancer in early trial

NCT ID NCT06855771

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests a drug called navlimetostat in about 130 people with advanced or metastatic non-small cell lung cancer that has a specific genetic change (MTAP deletion) and has worsened after other treatments. The main goal is to see if the drug can shrink tumors. Researchers will also monitor safety and how long any benefit lasts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Navlimetostat (BMS-986504)
What this could lead to: If successful, this could offer a new treatment option for people with a specific type of advanced lung cancer that has stopped responding to other therapies.
What could go wrong: This is an early-phase trial with only 130 participants, so results may not apply to everyone. The drug may not shrink tumors or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

AOU della Campania Luigi Vanvitelli
RECRUITING

Naples, Campania, 80131, Italy
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, Milano, 20162, Italy
Alaska Oncology and Hematology
RECRUITING

Anchorage, Alaska, 99508, United States
Beijing Chest Hospital,Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 101149, China
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
RECRUITING

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511, France
Centrul de Diagnostic si Tratament Provita
RECRUITING

Bucharest, 020335, Romania
Centrul de Oncologie "Sfântul Nectarie"
RECRUITING

Craiova, Dolj, 200542, Romania
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Chu Grenoble Alpes
RECRUITING

La Tronche, Isère, 38700, France
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING

Monza, Lombardy, 20900, Italy
Fred Hutchison Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
GenesisCare - Campbelltown
RECRUITING

Campbelltown, New South Wales, 2560, Australia
Groupe hospitalier Paris saint Joseph
RECRUITING

Paris, Île-de-France Region, 75014, France
Guangxi Medical University Affiliated Tumor Hospital
RECRUITING

Nanning, Guangxi, 530201, China
H.R.U Málaga - Hospital General
RECRUITING

Málaga, 29011, Spain
Hopitaux Universitaires Paris Centre-Hopital Cochin
RECRUITING

Paris, 75014, France
Hospices Civils de Lyon - Hopital Louis Pradel
RECRUITING

Bron, Rhône, 69677, France
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [Barcelona], 08035, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Madrid, Comunidad de, 28046, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
RECRUITING

Saint-Herblain, Loire-Atlantique, 44800, France
Hôpital Tenon
RECRUITING

Paris, 75970, France
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, 40138, Italy
Institut Català d'Oncologia - L'Hospitalet
RECRUITING

Hospitalet, Barcelona [Barcelona], 08907, Spain
Institut Curie
RECRUITING

Paris, 75248, France
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
RECRUITING

Bucharest, Bucharest, 022338, Romania
Institutul Oncologic Cluj
RECRUITING

Cluj-Napoca, 400015, Romania
Institutul Regional de Oncologie
RECRUITING

Iași, 700483, Romania
Istituto Nazionale Tumori IRCCS Fondazione Pascale
RECRUITING

Naples, Campania, 80131, Italy
Istituto Oncologico Veneto IRCCS
RECRUITING

Padova, Veneto, 35128, Italy
Kansai Medical University Hospital
RECRUITING

Hirakata, Osaka, 573-1191, Japan
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Karolinska Universitetssjukhuset Solna
RECRUITING

Solna, Stockholms Län [se-01], 171 64, Sweden
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
RECRUITING

München, Bavaria, 81377, Germany
Krankenhaus Martha-Maria Halle-Dölau
RECRUITING

Halle, Saxony-Anhalt, 06120, Germany
LinYi Cancer Hospital
RECRUITING

Linyi, Shandong, 276001, China
Local Institution - 0045
NOT_YET_RECRUITING

Marseille, Bouches-du-Rhône, 13385, France
Local Institution - 0079
NOT_YET_RECRUITING

Shirley, New York, 11967, United States
Local Institution - 0097
COMPLETED

Adelaide, South Australia, 5000, Australia
Local Institution - 0099
NOT_YET_RECRUITING

Boise, Idaho, 83712, United States
Mazowiecki Szpital Onkologiczny
RECRUITING

Wieliszew, Masovian Voivodeship, 05-135, Poland
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, England, B15 2TH, United Kingdom
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING

Iași, 700106, Romania
SC Radiotherapy Center Cluj SRL
RECRUITING

Florești, Cluj, 407280, Romania
Sahlgrenska Universitetssjukhuset
RECRUITING

Gothenburg, Västra Götalands Län [se-14], 413 45, Sweden
Sarah Cannon Research Institute UK
RECRUITING

London, London, City of, w1g 6ad, United Kingdom
Sendai Kousei Hospital
RECRUITING

Sendai, Miyagi, 9810914, Japan
Shandong Cancer Hospital
RECRUITING

Jinan, Shandong, 250117, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310016, China
Szpital Specjalistyczny w Prabutach Spolka z o.o.
RECRUITING

Prabuty, 82-550, Poland
Taizhou Hospital of Zhejiang Province
RECRUITING

Linhai, Zhejiang, 317000, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated hospital of Xiamen University
RECRUITING

Xiamen, Fujian, 361003, China
Universitaetsklinikum Koeln
RECRUITING

Cologne, 50937, Germany
Universitaetsklinikum Wuerzburg
RECRUITING

Würzburg, 97080, Germany
Universitätsklinikum Frankfurt Goethe-Universität
RECRUITING

Frankfurt am Main, Hesse, 60590, Germany
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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