New heart valve trial offers hope without Open-Heart surgery
NCT ID NCT05932615
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 33 times
Summary
This study tests a new heart valve device (Navitor TAVI) for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. It includes 1,500 participants who are at low or intermediate risk for surgery. The goal is to see if the device is safe and effective at replacing the damaged valve without major surgery.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AdventHealth Orlando
Orlando, Florida, 32825, United States
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Allegheny General Hospital - ASRI
Pittsburgh, Pennsylvania, 15212, United States
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Arkansas Heart Hospital
Little Rock, Arkansas, 72211, United States
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Ascension St. Vincent
Indianapolis, Indiana, 46290, United States
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Ascension Texas Cardiovascular
Austin, Texas, 78705, United States
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Aurora Medical Group
Milwaukee, Wisconsin, 53215, United States
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Austin Heart
Austin, Texas, 78756, United States
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Baptist Hospital of Miami
Miami, Florida, 33176, United States
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Baptist Memorial Hospital
Memphis, Tennessee, 38120, United States
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Basel University Hospital
Basel, Basel, 4031, Switzerland
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Baylor Scott & White - The Heart Hospital Plano
Plano, Texas, 75093, United States
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CHU Rennes, Pontchaillou
Rennes, Brittan, 35033, France
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Clinique Pasteur Toulouse
Toulouse, Midpyre, 31076, France
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Columbia University Medical Center/NYPH
New York, New York, 10032, United States
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East Carolina Heart Institute
Greenville, North Carolina, 27834, United States
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Endeavor Health
Evanston, Illinois, 60201, United States
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HCA Florida - JFK Hospital
Atlantis, Florida, 33462, United States
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HCA Florida Largo Hospital
Largo, Florida, 33770, United States
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HCA Florida Ocala Hospital
Ocala, Florida, 34471, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hillcrest Medical Center
Tulsa, Oklahoma, 74104, United States
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Hopital Haut Leveque
Pessac, AQT, 33600, France
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Houston Methodist
Houston, Texas, 77030, United States
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Institut de Cardiologie de Montreal (Montreal Heart Inst.)
Montreal, Quebec, H1T 1C8, Canada
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Intermountain Health St George Regional Hospital
St. George, Utah, 84790, United States
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John Hunter Hospital
Newcastle, New South Wales, 2300, Australia
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Kaiser Permanente Fontana Medical Center
Fontana, California, 92335, United States
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Lankenau Institute for Medical Research
Wynnewood, Pennsylvania, 19096, United States
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Los Robles Regional Medical Center
Thousand Oaks, California, 91360, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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MedStar Union Memorial Hospital
Baltimore, Maryland, 21218, United States
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Mission Health & Hospitals
Asheville, North Carolina, 28801, United States
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Monash Health
Clayton, Victoria, 3168, Australia
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Montefiore Medical Center - Moses Division
New York, New York, 10467, United States
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Morristown Medical Center
Morristown, New Jersey, 07962, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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MyMichigan Medical Center Midland
Midland, Michigan, 48670, United States
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North Central Heart
Sioux Falls, South Dakota, 57108, United States
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Northeast Georgia Medical Center
Gainesville, Georgia, 30501, United States
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Northwestern Memorial Hospital
Evanston, Illinois, 60201, United States
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Ochsner Medical Center
New Orleans, Louisiana, 70121, United States
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Ohio Health Research Institute
Columbus, Ohio, 43113, United States
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Piedmont Heart Institute
Atlanta, Georgia, 30309, United States
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Pinnacle Health System
Mechanicsburg, Pennsylvania, 17055, United States
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Presbyterian Hospital
Albuquerque, New Mexico, 87106, United States
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Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08901, United States
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Royal Adelaide Hospital
Adelaide, Saustrl, 5000, Australia
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Saint John Regional Hospital - New Brunswick Heart Centre
Saint John, NB E2L 4L4, Canada
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Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111, United States
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Sentara Norfolk General Hospital
Norfolk, Virginia, 23507, United States
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Shaare Zedek Medical Center
Jerusalem, Jeruslm, 9103102, Israel
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Southern California Permanente Medical Group - La Jolla
La Jolla, California, 92037, United States
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St. Francis Hospital
Roslyn, New York, 11576, United States
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St. Joseph's Hospital & Medical Center
Phoenix, Arizona, 85013, United States
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St. Joseph's Hospital & Medical Center
Denver, Colorado, 80218, United States
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St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
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St. Paul's Hospital
Vancouver, British Columbia, V6E 1M7, Canada
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St.-Johannes Hospital
Dortmund, N. RHIN, 44137, Germany
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Stanford University Medical Center
Stanford, California, 94305, United States
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Swedish Medical Center
Seattle, Washington, 98122, United States
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Tallahassee Research Institute
Tallahassee, Florida, 32308, United States
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The Alfred Hospital
Melbourne, Victoria, 3004, Australia
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The Christ Hospital
Cincinnati, Ohio, 45219, United States
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The Cleveland Clinic
Cleveland, Ohio, 44195, United States
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The Queen's Medical Center
Honolulu, Hawaii, 96814, United States
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The Royal Victoria Hospital
Montreal, Quebec, H4A3J1, Canada
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Tucson Medical Center
Tucson, Arizona, 85712, United States
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UTHealth Memorial Hermann
Houston, Texas, 77030, United States
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Universitair Medisch Centrum Groningen
Groningen, Grogen, 9713 GZ, Netherlands
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University Hospital - Univ. of Alabama at Birmingham (UAB)
Birmingham, Alabama, 35233, United States
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University of California at San Francisco
San Francisco, California, 94143, United States
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University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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University of Massachusetts Medical Center
Worcester, Massachusetts, 01655, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7, Canada
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Virginia Medical Center
Charlottesville, Virginia, 22908, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Via Christi Regional Medical Center - St. Francis Campus
Wichita, Kansas, 67226, United States
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Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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West Virginia University
Morgantown, West Virginia, 26506, United States
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Western Michigan Univ. Homer Stryker M.D. School of Medicine
Kalamazoo, Michigan, 49048, United States
Conditions
Explore the condition pages connected to this study.