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Fewer trips to the clinic for IVF? new study tests simpler embryo transfer timing

NCT ID NCT06307184

Knowledge-focused Sponsor: Instituto Valenciano de Infertilidade de Lisboa Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a natural-cycle approach to frozen embryo transfer can reduce the number of clinic visits needed before scheduling the transfer. Researchers will track 530 women undergoing IVF with donated eggs to see how many appointments are needed compared to standard methods. The goal is to make the process more convenient without compromising success.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this approach works, it could make frozen embryo transfer more convenient by requiring fewer clinic visits, saving time and stress for patients.
What could go wrong
This is an observational study, not a treatment trial, so it won't prove whether the approach improves pregnancy rates. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 530 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study group will include a prospectively recruited cohort of ovulatory patients undergoing their first or second FET attempt following oocyte donation in a natural proliferative phase protocol. The control group will include a retrospective cohort of ovulatory patients undergoing a natural cycle frozen embryo transfer following oocyte donation.

Ages

18 to 49 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Endometrial thickness ≥ 7 mm on the day of starting progesterone-based luteal phase support (LPS) * Serum progesterone levels \<1.5 ng/ml on the day of starting progesterone-based LPS * LPS with micronized progesterone 400mg b.i.d. * Regular cycles (\>24 days, ≤ 38 days) * IVF/ICSI with donated oocytes * Single blastocyst stage embryo transfer * First or second embryo transfer from the same cohort Exclusion Criteria: * Use of exogenous ovarian stimulation during FET * Untreated hydrosalpinx, polyp, submucous myomas or severe adenomyosis * Recurrent pregnancy loss (≥ 3 previous pregnancy losses) * Recurrent implantation failure with embryos from oocyte donation (≥ 3 previous failed embryo transfers) * Personalized initiation of exogenous progesterone according to a previous endometrial receptivity assay test

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Frozen embryo transfer

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Instituto Valenciano de Infertilidade

    RECRUITING

    Lisbon, Portugal

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