Which drug stops the sting? new trial tests nalbuphine vs lidocaine for propofol pain

NCT ID NCT07422558

Not yet recruiting Symptom relief Sponsor: Hayatabad Medical Complex Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

Propofol, a common anesthesia drug, often causes pain when injected. This trial will compare two drugs—nalbuphine and lidocaine—given before propofol to see which reduces that pain better. 92 adults having elective surgery will take part, and their pain will be measured on a simple scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nalbuphine and lidocaine
What this could lead to: If one drug works better, it could become a standard way to reduce injection pain for patients receiving propofol anesthesia.
What could go wrong: This is a small, early-stage trial with only 92 participants. Previous studies have shown conflicting results, so neither drug may prove clearly better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Procedural

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROCEDURAL PAIN

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