Nasal spray vs needle: new study tests easier way to mature eggs for freezing

NCT ID NCT06763926

Not yet recruiting Disease control Sponsor: Fundacion Dexeus Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a nasal spray (nafarelin) to a standard injection (triptorelin) for triggering final egg maturation in women freezing their eggs for fertility preservation. About 154 women will be randomly assigned to one of the two triggers during ovarian stimulation. The main goal is to see if the nasal spray works as well as the injection at producing mature eggs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nafarelin (intranasal spray) and triptorelin (injection)
What this could lead to: If nafarelin works as well as triptorelin, it could offer a needle-free option for triggering final egg maturation, making fertility preservation more comfortable.
What could go wrong: This is a small, early-phase non-inferiority trial (154 participants) comparing two established drugs; it may not show nafarelin is as effective, and individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for FERTILITY PRESERVATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FERTILITY PRESERVATION

Contacts and locations

Locations

Departamento de Ginecología Obstetricia y Reproducción. Hospital Universitari Dexeus

Barcelona, 08037, Spain
Dexeus Mujer Reus

Reus, Tarragona, 43202, Spain
Dexeus Mujer Sabadell

Sabadell, Barcelona, 08203, Spain
Dexeus Mujer Sant Cugat

Sant Cugat del Vallès, Barcelona, 08190, Spain
Dexeus Mujer Tarragona

Tarragona, 43206, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.