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Lung cancer drug trial halted early: what we know

NCT ID NCT05652868

Terminated Disease control Sponsor: Mythic Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tested a new drug called MYTX-011 for people with advanced non-small cell lung cancer (NSCLC) that had spread or come back after standard treatments. The drug is an antibody-drug conjugate designed to deliver a powerful chemotherapy directly to cancer cells. The study was terminated, but it aimed to find a safe dose and check if the drug could shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED NON-SMALL CELL LUNG CANCER ADVANCED NON-SMALL CELL NON-SQUAMOUS LUNG CANCER ADVANCED NON-SMALL CELL SQUAMOUS LUNG CANCER NON-SMALL CELL LUNG CANCER NSCLC NSCLC STAGE IIIB NSCLC STAGE IV

Contacts and locations

Locations

  • APHM - Hopital de la Timone

    Marseille, France

  • Atlantic Health System

    Morristown, New Jersey, 07960, United States

  • Beatson West of Scotland Cancer Centre

    Glasgow, United Kingdom

  • Blacktown Hospital

    Blacktown, New South Wales, 2148, Australia

  • Cancer Research SA

    Adelaide, South Australia, 5011, Australia

  • Centre Léon Bérard - Lyon

    Lyon, France

  • Chris O'Brien Lifehouse

    Camperdown, New South Wales, 2050, Australia

  • Chungbuk National Univ. Hospital

    Incheon, 21565, South Korea

  • Churchill Hospital - Oxford University Hospitals

    Oxford, OX3 7LJ, United Kingdom

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98019, United States

  • Gachon University

    Seongnam, South Korea

  • Gustave Roussy Institute

    Villejuif, France

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, 92663, United States

  • Hospital Clinico Universitario de Valencia

    Valencia, Spain

  • Hospital Quirónsalud Málaga

    Málaga, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Lozano Blesa

    Zaragoza, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Spain

  • INSTITUT Curie (lead)

    Paris, France

  • Institut Bergonié-Bordeaux

    Bordeaux, France

  • Institut de Cancérologie de l'Ouest (ICO institute)-St Herblain

    Nantes, France

  • Instituto Oncológico Dr Rosell (IOR) - Hospital Univ. Dexeus

    Barcelona, Spain

  • Kosin Univ. Gospel Hospital

    Busan, South Korea

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • MUSC Hollings Cancer Center

    Charleston, South Carolina, 29425, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • NEXT Oncology

    Fairfax, Virginia, 22031, United States

  • NYU Langone Medical Center

    New York, New York, 10016, United States

  • National Cancer Center

    Seoul, 03080, South Korea

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Taiwan University Cancer Centre

    Taipei, Taiwan

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • National Taiwan University Hospital Hsin-Chu Branch

    Zhubei, 302058, Taiwan

  • Nebraska Cancer Specialists

    Omaha, Nebraska, 68130, United States

  • Newcastle upon Tyne Hospital (NHS)

    Newcastle, United Kingdom

  • Oncopole Claudius Regaud, IUCT-Oncopole

    Toulouse, France

  • Piedmont Physicians Medical Oncology

    Atlanta, Georgia, 30318, United States

  • Queen Elizabeth Hospital

    Adelaide, South Australia, 5000, Australia

  • START Barcelona-HM CIOCC Early Phase Program

    Barcelona, Spain

  • START Centro Integral Oncologico Calra Campal

    Madrid, Spain

  • START Madrid-FJD, Hospital Fundación Jiménez Díaz

    Madrid, Spain

  • Samsung Medical Center

    Seoul, South Korea

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Seoul National University Hospital

    Seoul, MA, 01886, South Korea

  • Severance Hospital

    Seoul, South Korea

  • St. Vincent Hospital

    Suwon, South Korea

  • Taichung Veterans General Hospital

    Taichung, MA, 01886, Taiwan

  • Taipei Medical University Hospital

    Taipei, 110301, Taiwan

  • UCLA

    Los Angeles, California, 90095, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • University College London Hospitals NHS Foundation Trust

    London, W1T 7HA, United Kingdom

  • University of California San Diego

    La Jolla, California, 92037, United States

  • Washington University School of Medicine in St. Louis

    St Louis, Missouri, 63110, United States

  • Winship Cancer Institute, Emory University

    Atlanta, Georgia, 30322, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.