New drug combo aims to shrink spleens and ease symptoms in blood cancer patients

NCT ID NCT04562389

Summary

This study is testing whether adding a new drug called selinexor to an existing standard drug (ruxolitinib) works better for people newly diagnosed with myelofibrosis, a serious bone marrow cancer. The main goals are to see if the combination shrinks enlarged spleens more effectively and reduces disease symptoms like fatigue and pain. The trial has completed its initial safety phase and is now in a larger Phase 3 stage comparing the two-drug combo against the standard drug plus a placebo.

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Contacts and locations

Locations

  • AIDPORT

    Skórzewo, Greater Poland Voivodeship, 60-185, Poland

  • Aarhus Universitetshospital

    Aarhus N, Central Jutland, 8200, Denmark

  • Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan

    Bruges, West-Vlaanderen, 8000, Belgium

  • Azienda Ospedaliera Ordine Mauriziano di Torino

    Torino, 10128, Italy

  • Azienda Ospedaliero - Universitaria Careggi

    Florence, 50134, Italy

  • Azienda Ospedaliero Universitaria Policlinico Gaspare Rodolico - San Marco - Catania/ Presidio G. Rodolico

    Catania, Catania, 95123, Italy

  • Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino

    Torino, Turin, 10126, Italy

  • Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara

    Novara, Novara, 28100, Italy

  • Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi

    Bologna, 40138, Italy

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, Milan, 20162, Italy

  • Bankstown-Lidcombe Hospital

    Bankstown, New South Wales, 2200, Australia

  • Campbelltown Hospital

    Campbelltown, New South Wales, 2560, Australia

  • Carmel Medical Center

    Haifa, Haifa District, 3436212, Israel

  • Centre Hospitalier Lyon-Sud

    Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France

  • Centre Hospitalier Universitaire Estaing

    Clermont-Ferrand, Aubergne, 63003, France

  • Centre Hospitalier Universitaire d'Angers

    Angers, Pays de la Loire Region, 49 933, France

  • Centre Hospitalier Universitaire de Saint-Étienne

    Saint-Priest-en-Jarez, Pays de la Loire Region, 42271, France

  • Centro Ricerche Cliniche di Verona

    Verona, 37134, Italy

  • Chang Gung Memorial Hospital - Kaohsiung Branch

    Kaohsiung City, 83301, Taiwan

  • Chang Gung Memorial Hospital - Linkou Branch

    Taoyuan District, 33305, Taiwan

  • China Medical University Hospital

    Taichung, Taichung, 40447, Taiwan

  • Chonnam National University Hwasun Hospital

    Hwasun, Jeollanam-do, 58128, South Korea

  • Chu De Nîmes - Institut De Cancérologie Du Gard

    Nîmes, Gard, 30029, France

  • City of Hope

    Duarte, California, 91010, United States

  • City of Hope - Irvine Lennar - Satellite

    Irvine, California, 92618, United States

  • Coltea - Spital Clinic

    Bucharest, 020125, Romania

  • Complejo Asistencial Universitario de Salamanca - Hospital Clínico

    Salamanca, 37007, Spain

  • Dolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców Szpiku

    Wroclaw, Lower Silesian Voivodeship, 53-439, Poland

  • Duke Cancer Institue

    Durham, North Carolina, 27705, United States

  • Emek Medical Center

    Afula, Northern District, 1834111, Israel

  • Fakultní Nemocnice Hradec Králové

    Hradec Králové, 500 05, Czechia

  • Fakultní Nemocnice Olomouc

    Olomouc, 779 00, Czechia

  • Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico

    Milan, Milan, 20122, Italy

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Fondazione IRCCS San Gerardo dei Tintori

    Monza, Monza and Brianza, 20900, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Roma, 00168, Italy

  • Fred Hutchinson Cancer Center - SCAA South Lake Union

    Seattle, Washington, 98109, United States

  • General Hospital of Athens "Alexandra"

    Athens, Attica, 115 28, Greece

  • General Hospital of Thessaloniki George Papanikolaou

    Thessaloniki, Central Macedonia, 570 10, Greece

  • Georgetown Lombardi Comprehensive Center

    Washington D.C., District of Columbia, 20007, United States

  • Guy's and St Thomas' NHS Foundation Trust

    London, England, SE1 9RT, United Kingdom

  • Győr-Moson-Sopron Vármegyei Petz Aladár Egyetemi Oktató Kórház

    Győr, Győr-Moson-Sopron, 9023, Hungary

  • Hadassah University Hospital - Mount Scopus - Satellite Site

    Jerusalem, Jerusalem, 9112001, Israel

  • Hadassah University Hospital Ein Kerem

    Jerusalem, Jerusalem, 9112001, Israel

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    Murcia, 30120, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital General Universitario Gregorio Marañón

    Madrid, 28007, Spain

  • Hospital San Pedro de Alcantara

    Cáceres, Cáceres, 10003, Spain

  • Hospital Universitari Vall d'Hebrón

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Central de Asturias

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario Lucus Augusti

    Lugo, 27003, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Universitario de Gran Canaria Doctor Negrin

    Las Palmas de Gran Canaria, 35010, Spain

  • Hospital de Día Quirónsalud Zaragoza

    Zaragoza, Zaragoza, 50012, Spain

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Hôpital Bretonneau

    Tours, Indre-et-Loire, 37044, France

  • Hôpital Cochin

    Paris, Île-de-France Region, 75014, France

  • Hôpital Emile Muller

    Mulhouse, Grand Est, 68100, France

  • Hôpital Huriez

    Lille, Hauts-de-France, 59037, France

  • Hôpital Morvan

    Brest, Brittany Region, 29200, France

  • Hôpital Saint-Louis

    Paris, 75010, France

  • Hôpital Universitaire Pitié Salpêtrière

    Paris, Île-de-France Region, 75013, France

  • Hôpital l'Archet - CHU Nice

    Nice, PACA, 06202, France

  • IRCCS Centro di Riferimento Oncologico di Basilicata

    Rionero in Vulture, Potenza, 85028, Italy

  • IRCCS Ospedale Policlinico San Martino

    Genova, Genoa, 16132, Italy

  • Icon Cancer Centre - Wesley

    South Brisbane, Queensland, 4101, Australia

  • Imperial College Healthcare NHS Trust

    London, W12 0HS, United Kingdom

  • Institut Bergonié

    Bordeaux, Aquitaine, 33000, France

  • Institut Català d'Oncologia Girona (ICO Girona)

    Girona, 17007, Spain

  • Institut Català d'Oncologia Badalona

    Badalona, 08916, Spain

  • Institutul Oncologic Prof. Dr. Ion Chiricuta

    Cluj-Napoca, Cluj, 400015, Romania

  • Institutul Regional De Oncologie Iasi

    Iași, 700483, Romania

  • Istituto Europeo di Oncologia

    Milan, Milan, 20141, Italy

  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST

    Meldola, Forli-Cesena, 47014, Italy

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 80756, Taiwan

  • Kliniken Ostalb - Stauferklinikum Schwäbisch Gmünd

    Mutlangen, Baden-Wurttemberg, 73557, Germany

  • Kyungpook National University Hospital

    Daegu, 41944, South Korea

  • Laiko General Hospital of Athens

    Athens, Attica, 115 27, Greece

  • Lakeridge Health

    Oshawa, Ontario, L1G 2B9, Canada

  • Liverpool Hospital

    Liverpool, New South Wales, 2170, Australia

  • Marien Hospital Düsseldorf

    Düsseldorf, North Rhine-Westphalia, 40479, Germany

  • Maryland Oncology Hematology

    Columbia, Maryland, 21044, United States

  • Maryland Oncology Hematology-Satellite

    Annapolis, Maryland, 21401, United States

  • Maryland Oncology Hematology-Satellite

    Brandywine, Maryland, 21004, United States

  • Maryland Oncology Hematology-Satellite

    Rockville, Maryland, 20850, United States

  • Maryland Oncology Hematology-Satellite

    Silver Spring, Maryland, 20904, United States

  • Medicover Integrated Clinical Services (MICS) - Centrum Medyczne Toruń

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Mount Sinai Health System

    New York, New York, 10029, United States

  • National Taiwan University Hospital

    Taipei, 10048, Taiwan

  • Norton Cancer Institute - Saint Matthews

    Louisville, Kentucky, 40207, United States

  • Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute

    Columbus, Ohio, 43210, United States

  • OhioHealth

    Columbus, Ohio, 43214, United States

  • One Clinical Research

    Nedlands, Western Australia, 6009, Australia

  • Oxford University Hospitals NHS Foundation Trust

    Oxford, England, OX3 7LE, United Kingdom

  • Pratia Onkologia Katowice

    Katowice, Silesian Voivodeship, 40-519, Poland

  • Pusan National University Hospital

    Busan, Gwang'yeogsi, 49241, South Korea

  • Rambam Health Care Campus

    Haifa, Haifa District, 3109601, Israel

  • Research Institute of the McGill University Health Centre

    Montreal, Quebec, H4A 3J1, Canada

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Samsung Medical Center

    Seoul, 6351, South Korea

  • Semmelweis Egyetem

    Budapest, 1088, Hungary

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggido, 13605, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital

    Seoul, 03722, South Korea

  • Shamir Medical Center (Assaf Harofeh)

    Be’er Ya‘aqov, Central District, 7030000, Israel

  • Smilow Cancer Hospital - New Haven

    New Haven, Connecticut, 06511, United States

  • Spaarne Gasthuis - Hoofddorp

    Hoofddorp, North Holland, 2134 TM, Netherlands

  • Specialized Hospital for Active Treatment of Hematological Diseases - EAD Sofia

    Sofia, 1797, Bulgaria

  • Specjalistyczny Szpital im. dra Alfreda Sokołowskiego w Wałbrzychu

    Wałbrzych, Silesian Voivodeship, 58-309, Poland

  • Spitalul Clinic Colentina

    Bucharest, 20125, Romania

  • Spitalul Clinic Judetean De Urgenta Târgu Mureș

    Târgu Mureş, Mureș County, 540136, Romania

  • Spitalul Filantropia - Craiova

    Craiova, Dolj, 200136, Romania

  • Städtisches Krankenhaus Kiel

    Kiel, Schleswig-Holstein, 24116, Germany

  • Szpital Specjalistyczny w Brzozowie - Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza

    Brzozów, Podkarpackie Voivodeship, 36-200, Poland

  • Tang Severinsen, Marianne

    Aalborg, North Denmark, 9000, Denmark

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • Texas Oncology

    Dallas, Texas, 75246, United States

  • The Cancer & Hematology Centers -Satellite Site

    Grand Rapids, Michigan, 49546, United States

  • The Cancer & Hematology Centers of Muskegon

    Norton Shores, Michigan, 49444, United States

  • The Catholic University of Korea - Seoul St. Mary's Hospital

    Seoul, 06591, South Korea

  • The Chaim Sheba Medical Center

    Ramat Gan, Central District, 5265601, Israel

  • The Clatterbridge Cancer Centre NHS Foundation Trust

    Liverpool, LZ 8XP, United Kingdom

  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • The Oncology Institute of Hope & Innovation

    Pasadena, California, 91105, United States

  • The Sidney Kimmel Comprehensive Cancer Center

    Baltimore, Maryland, 21205, United States

  • UAB Division of Hematology/Oncology

    Birmingham, Alabama, 35294, United States

  • UCLA

    Los Angles, California, 90095, United States

  • UCLA - Satellite Site

    Beverly Hills, California, 90210, United States

  • UCLA - Satellite Site

    Encino, California, 93003, United States

  • USOR - Oncology Hematology Care - Kenwood

    Cincinnati, Ohio, 45242, United States

  • USOR - Rocky Mountain Cancer Centers - Aurora

    Aurora, Colorado, 80045, United States

  • USOR - Virginia Cancer Specialists - Gainesville Office

    Gainesville, Virginia, 20155, United States

  • USOR - Virginia Oncology Associates - Virginia Beach

    Virginia Beach, Virginia, 23456, United States

  • Umberto I - Policlinico di Roma

    Roma, Rome, 00161, Italy

  • United Lincolnshire Hospitals NHS Trust

    Boston, PE21 9QS, United Kingdom

  • United Lincolnshire Hospitals NHS Trust-Satellite Site

    Boston, PE21 9QS, United Kingdom

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ, Netherlands

  • Universitair Ziekenhuis Gent

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, Flemish Brabant, 3000, Belgium

  • University General Hospital Attikon

    Athens, Attica, 124 62, Greece

  • University General Hospital of Ioannina

    Ioánnina, Thessaly, 455 00, Greece

  • University General Hospital of Larissa, Hematology Department

    Larissa, Thessaly, 41110, Greece

  • University Multiprofile Hospital for Active Treatment - Prof. Dr. Stoyan Kirkovich

    Stara Zagora, 6003, Bulgaria

  • University Multiprofile Hospital for Active Treatment Aleksandrovska

    Sofia, 1431, Bulgaria

  • University Multiprofile Hospital for Active Treatment St. Ivan Rilski

    Sofia, 1431, Bulgaria

  • University Multiprofile Hospital for Active Treatment Sveti George - Base 1

    Plovdiv, 4002, Bulgaria

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 2G3, Canada

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Wisconsin - Madison

    Madison, Wisconsin, 53792, United States

  • Università Campus Bio-Medico di Roma

    Rome, Viterbo, 00128, Italy

  • Universitätsklinikum Halle

    Halle, Saxony-Anhalt, 6120, Germany

  • Universitätsklinikum Jena

    Jena, Thuringia, 7747, Germany

  • Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie

    Lublin, Lublin Voivodeship, 20-093, Poland

  • Uniwersyteckie Centrum Kliniczne w Gdańsku

    Gdansk, Pomeranian Voivodeship, 80-952, Poland

  • VCU Massey Cancer Center

    Richmond, Virginia, 23298, United States

  • Vanderbilt Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Vseobecna Fakultni Nemocnice v Praze

    Prague, Prague, 128 08, Czechia

  • West Virginia University Cancer Institute, Wheeling Hospital

    Wheeling, West Virginia, 26003, United States

  • Western Galilee Hospital-Nahariya

    Nahariya, Northern District, 2210001, Israel

  • ZNA Stuivenberg

    Antwerp, 2060, Belgium

  • ZNA Stuivenberg - Satelite

    Antwerp, 2030, Belgium

Conditions

Explore the condition pages connected to this study.