New drug combo aims to shrink spleens and ease symptoms in blood cancer patients
NCT ID NCT04562389
Summary
This study is testing whether adding a new drug called selinexor to an existing standard drug (ruxolitinib) works better for people newly diagnosed with myelofibrosis, a serious bone marrow cancer. The main goals are to see if the combination shrinks enlarged spleens more effectively and reduces disease symptoms like fatigue and pain. The trial has completed its initial safety phase and is now in a larger Phase 3 stage comparing the two-drug combo against the standard drug plus a placebo.
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Contacts and locations
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Locations
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AIDPORT
Skórzewo, Greater Poland Voivodeship, 60-185, Poland
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Aarhus Universitetshospital
Aarhus N, Central Jutland, 8200, Denmark
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Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan
Bruges, West-Vlaanderen, 8000, Belgium
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Azienda Ospedaliera Ordine Mauriziano di Torino
Torino, 10128, Italy
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Azienda Ospedaliero - Universitaria Careggi
Florence, 50134, Italy
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Azienda Ospedaliero Universitaria Policlinico Gaspare Rodolico - San Marco - Catania/ Presidio G. Rodolico
Catania, Catania, 95123, Italy
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Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino
Torino, Turin, 10126, Italy
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Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara
Novara, Novara, 28100, Italy
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Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi
Bologna, 40138, Italy
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Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, Milan, 20162, Italy
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Bankstown-Lidcombe Hospital
Bankstown, New South Wales, 2200, Australia
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Campbelltown Hospital
Campbelltown, New South Wales, 2560, Australia
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Carmel Medical Center
Haifa, Haifa District, 3436212, Israel
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Centre Hospitalier Lyon-Sud
Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
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Centre Hospitalier Universitaire Estaing
Clermont-Ferrand, Aubergne, 63003, France
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Centre Hospitalier Universitaire d'Angers
Angers, Pays de la Loire Region, 49 933, France
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Centre Hospitalier Universitaire de Saint-Étienne
Saint-Priest-en-Jarez, Pays de la Loire Region, 42271, France
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Centro Ricerche Cliniche di Verona
Verona, 37134, Italy
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Chang Gung Memorial Hospital - Kaohsiung Branch
Kaohsiung City, 83301, Taiwan
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Chang Gung Memorial Hospital - Linkou Branch
Taoyuan District, 33305, Taiwan
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China Medical University Hospital
Taichung, Taichung, 40447, Taiwan
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Chonnam National University Hwasun Hospital
Hwasun, Jeollanam-do, 58128, South Korea
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Chu De Nîmes - Institut De Cancérologie Du Gard
Nîmes, Gard, 30029, France
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City of Hope
Duarte, California, 91010, United States
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City of Hope - Irvine Lennar - Satellite
Irvine, California, 92618, United States
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Coltea - Spital Clinic
Bucharest, 020125, Romania
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Complejo Asistencial Universitario de Salamanca - Hospital Clínico
Salamanca, 37007, Spain
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Dolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców Szpiku
Wroclaw, Lower Silesian Voivodeship, 53-439, Poland
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Duke Cancer Institue
Durham, North Carolina, 27705, United States
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Emek Medical Center
Afula, Northern District, 1834111, Israel
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Fakultní Nemocnice Hradec Králové
Hradec Králové, 500 05, Czechia
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Fakultní Nemocnice Olomouc
Olomouc, 779 00, Czechia
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Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico
Milan, Milan, 20122, Italy
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Monza and Brianza, 20900, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, 00168, Italy
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Fred Hutchinson Cancer Center - SCAA South Lake Union
Seattle, Washington, 98109, United States
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General Hospital of Athens "Alexandra"
Athens, Attica, 115 28, Greece
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General Hospital of Thessaloniki George Papanikolaou
Thessaloniki, Central Macedonia, 570 10, Greece
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Georgetown Lombardi Comprehensive Center
Washington D.C., District of Columbia, 20007, United States
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Guy's and St Thomas' NHS Foundation Trust
London, England, SE1 9RT, United Kingdom
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Győr-Moson-Sopron Vármegyei Petz Aladár Egyetemi Oktató Kórház
Győr, Győr-Moson-Sopron, 9023, Hungary
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Hadassah University Hospital - Mount Scopus - Satellite Site
Jerusalem, Jerusalem, 9112001, Israel
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Hadassah University Hospital Ein Kerem
Jerusalem, Jerusalem, 9112001, Israel
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, 30120, Spain
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Hospital Clínico Universitario de Valencia
Valencia, 46010, Spain
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Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
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Hospital San Pedro de Alcantara
Cáceres, Cáceres, 10003, Spain
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Hospital Universitari Vall d'Hebrón
Barcelona, 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario Lucus Augusti
Lugo, 27003, Spain
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Hospital Universitario Ramón y Cajal
Madrid, 28034, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
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Hospital Universitario de Gran Canaria Doctor Negrin
Las Palmas de Gran Canaria, 35010, Spain
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Hospital de Día Quirónsalud Zaragoza
Zaragoza, Zaragoza, 50012, Spain
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Hôpital Bretonneau
Tours, Indre-et-Loire, 37044, France
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Hôpital Cochin
Paris, Île-de-France Region, 75014, France
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Hôpital Emile Muller
Mulhouse, Grand Est, 68100, France
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Hôpital Huriez
Lille, Hauts-de-France, 59037, France
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Hôpital Morvan
Brest, Brittany Region, 29200, France
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Hôpital Saint-Louis
Paris, 75010, France
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Hôpital Universitaire Pitié Salpêtrière
Paris, Île-de-France Region, 75013, France
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Hôpital l'Archet - CHU Nice
Nice, PACA, 06202, France
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IRCCS Centro di Riferimento Oncologico di Basilicata
Rionero in Vulture, Potenza, 85028, Italy
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IRCCS Ospedale Policlinico San Martino
Genova, Genoa, 16132, Italy
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Icon Cancer Centre - Wesley
South Brisbane, Queensland, 4101, Australia
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Imperial College Healthcare NHS Trust
London, W12 0HS, United Kingdom
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Institut Bergonié
Bordeaux, Aquitaine, 33000, France
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Institut Català d'Oncologia Girona (ICO Girona)
Girona, 17007, Spain
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Institut Català d'Oncologia Badalona
Badalona, 08916, Spain
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Institutul Oncologic Prof. Dr. Ion Chiricuta
Cluj-Napoca, Cluj, 400015, Romania
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Institutul Regional De Oncologie Iasi
Iași, 700483, Romania
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Istituto Europeo di Oncologia
Milan, Milan, 20141, Italy
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Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST
Meldola, Forli-Cesena, 47014, Italy
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John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 80756, Taiwan
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Kliniken Ostalb - Stauferklinikum Schwäbisch Gmünd
Mutlangen, Baden-Wurttemberg, 73557, Germany
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Kyungpook National University Hospital
Daegu, 41944, South Korea
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Laiko General Hospital of Athens
Athens, Attica, 115 27, Greece
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Lakeridge Health
Oshawa, Ontario, L1G 2B9, Canada
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Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
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Marien Hospital Düsseldorf
Düsseldorf, North Rhine-Westphalia, 40479, Germany
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Maryland Oncology Hematology
Columbia, Maryland, 21044, United States
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Maryland Oncology Hematology-Satellite
Annapolis, Maryland, 21401, United States
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Maryland Oncology Hematology-Satellite
Brandywine, Maryland, 21004, United States
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Maryland Oncology Hematology-Satellite
Rockville, Maryland, 20850, United States
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Maryland Oncology Hematology-Satellite
Silver Spring, Maryland, 20904, United States
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Medicover Integrated Clinical Services (MICS) - Centrum Medyczne Toruń
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Mount Sinai Health System
New York, New York, 10029, United States
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National Taiwan University Hospital
Taipei, 10048, Taiwan
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Norton Cancer Institute - Saint Matthews
Louisville, Kentucky, 40207, United States
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Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute
Columbus, Ohio, 43210, United States
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OhioHealth
Columbus, Ohio, 43214, United States
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One Clinical Research
Nedlands, Western Australia, 6009, Australia
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Oxford University Hospitals NHS Foundation Trust
Oxford, England, OX3 7LE, United Kingdom
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Pratia Onkologia Katowice
Katowice, Silesian Voivodeship, 40-519, Poland
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Pusan National University Hospital
Busan, Gwang'yeogsi, 49241, South Korea
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Rambam Health Care Campus
Haifa, Haifa District, 3109601, Israel
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Research Institute of the McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
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Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
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Samsung Medical Center
Seoul, 6351, South Korea
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Semmelweis Egyetem
Budapest, 1088, Hungary
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggido, 13605, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital
Seoul, 03722, South Korea
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Shamir Medical Center (Assaf Harofeh)
Be’er Ya‘aqov, Central District, 7030000, Israel
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Smilow Cancer Hospital - New Haven
New Haven, Connecticut, 06511, United States
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Spaarne Gasthuis - Hoofddorp
Hoofddorp, North Holland, 2134 TM, Netherlands
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Specialized Hospital for Active Treatment of Hematological Diseases - EAD Sofia
Sofia, 1797, Bulgaria
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Specjalistyczny Szpital im. dra Alfreda Sokołowskiego w Wałbrzychu
Wałbrzych, Silesian Voivodeship, 58-309, Poland
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Spitalul Clinic Colentina
Bucharest, 20125, Romania
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Spitalul Clinic Judetean De Urgenta Târgu Mureș
Târgu Mureş, Mureș County, 540136, Romania
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Spitalul Filantropia - Craiova
Craiova, Dolj, 200136, Romania
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Städtisches Krankenhaus Kiel
Kiel, Schleswig-Holstein, 24116, Germany
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Szpital Specjalistyczny w Brzozowie - Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza
Brzozów, Podkarpackie Voivodeship, 36-200, Poland
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Tang Severinsen, Marianne
Aalborg, North Denmark, 9000, Denmark
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Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
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Texas Oncology
Dallas, Texas, 75246, United States
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The Cancer & Hematology Centers -Satellite Site
Grand Rapids, Michigan, 49546, United States
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The Cancer & Hematology Centers of Muskegon
Norton Shores, Michigan, 49444, United States
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The Catholic University of Korea - Seoul St. Mary's Hospital
Seoul, 06591, South Korea
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The Chaim Sheba Medical Center
Ramat Gan, Central District, 5265601, Israel
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The Clatterbridge Cancer Centre NHS Foundation Trust
Liverpool, LZ 8XP, United Kingdom
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, NE7 7DN, United Kingdom
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The Oncology Institute of Hope & Innovation
Pasadena, California, 91105, United States
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The Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21205, United States
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UAB Division of Hematology/Oncology
Birmingham, Alabama, 35294, United States
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UCLA
Los Angles, California, 90095, United States
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UCLA - Satellite Site
Beverly Hills, California, 90210, United States
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UCLA - Satellite Site
Encino, California, 93003, United States
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USOR - Oncology Hematology Care - Kenwood
Cincinnati, Ohio, 45242, United States
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USOR - Rocky Mountain Cancer Centers - Aurora
Aurora, Colorado, 80045, United States
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USOR - Virginia Cancer Specialists - Gainesville Office
Gainesville, Virginia, 20155, United States
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USOR - Virginia Oncology Associates - Virginia Beach
Virginia Beach, Virginia, 23456, United States
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Umberto I - Policlinico di Roma
Roma, Rome, 00161, Italy
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United Lincolnshire Hospitals NHS Trust
Boston, PE21 9QS, United Kingdom
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United Lincolnshire Hospitals NHS Trust-Satellite Site
Boston, PE21 9QS, United Kingdom
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Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
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Universitair Ziekenhuis Gent
Ghent, Oost-Vlaanderen, 9000, Belgium
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Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, Flemish Brabant, 3000, Belgium
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University General Hospital Attikon
Athens, Attica, 124 62, Greece
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University General Hospital of Ioannina
Ioánnina, Thessaly, 455 00, Greece
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University General Hospital of Larissa, Hematology Department
Larissa, Thessaly, 41110, Greece
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University Multiprofile Hospital for Active Treatment - Prof. Dr. Stoyan Kirkovich
Stara Zagora, 6003, Bulgaria
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University Multiprofile Hospital for Active Treatment Aleksandrovska
Sofia, 1431, Bulgaria
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University Multiprofile Hospital for Active Treatment St. Ivan Rilski
Sofia, 1431, Bulgaria
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University Multiprofile Hospital for Active Treatment Sveti George - Base 1
Plovdiv, 4002, Bulgaria
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University of Alberta Hospital
Edmonton, Alberta, T6G 2G3, Canada
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of Wisconsin - Madison
Madison, Wisconsin, 53792, United States
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Università Campus Bio-Medico di Roma
Rome, Viterbo, 00128, Italy
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Universitätsklinikum Halle
Halle, Saxony-Anhalt, 6120, Germany
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Universitätsklinikum Jena
Jena, Thuringia, 7747, Germany
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Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie
Lublin, Lublin Voivodeship, 20-093, Poland
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Uniwersyteckie Centrum Kliniczne w Gdańsku
Gdansk, Pomeranian Voivodeship, 80-952, Poland
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VCU Massey Cancer Center
Richmond, Virginia, 23298, United States
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Vanderbilt Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Vseobecna Fakultni Nemocnice v Praze
Prague, Prague, 128 08, Czechia
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West Virginia University Cancer Institute, Wheeling Hospital
Wheeling, West Virginia, 26003, United States
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Western Galilee Hospital-Nahariya
Nahariya, Northern District, 2210001, Israel
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ZNA Stuivenberg
Antwerp, 2060, Belgium
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ZNA Stuivenberg - Satelite
Antwerp, 2030, Belgium
Conditions
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