Could a smaller monkeypox vaccine dose protect just as well?
NCT ID NCT05512949
First seen Apr 30, 2026 · Last updated May 16, 2026 · Updated 3 times
Summary
This study tested whether giving smaller doses of the MVA-BN monkeypox vaccine under the skin (instead of the standard full dose into the fat) still provides good protection. About 229 healthy adults aged 18–50 received either one-fifth or one-tenth of the standard dose under the skin, or the full dose as usual. Researchers measured immune responses to see if the lower doses were as effective.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Baylor College of Medicine
Houston, Texas, 77030-3411, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115-6110, United States
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George Washington University Medical Faculty Associates
Washington D.C., District of Columbia, 20037, United States
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NIH Clinical Research Center, Investigational Drug Management and Research Section
Bethesda, Maryland, 20892-1504, United States
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Saint Louis University Center for Vaccine Development
St Louis, Missouri, 63104-1015, United States
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The Hope Clinic of Emory University
Decatur, Georgia, 30030, United States
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University of California, San Diego (UCSD) - Antiviral Research Center (AVRC)
San Diego, California, 92103-8208, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
Conditions
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