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Own muscle cells injected into sphincter may curb fecal incontinence

NCT ID NCT04976153

Recruiting now Disease control Sponsor: Innovacell GmbH Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This Phase 3 trial tests whether injecting a patient's own muscle cells into the anal sphincter can reduce episodes of fecal incontinence. The study enrolls adults with urge incontinence due to a weak or damaged sphincter who have not improved with standard treatments. Participants receive either the cell injection or a placebo, and researchers track changes in incontinence frequency over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Autologous muscle-derived cells
What this could lead to
If successful, this could offer a new treatment option for people with fecal incontinence who haven't improved with standard care.
What could go wrong
This is an advanced trial, but the treatment involves a surgical procedure and may not work for everyone. Risks include injection site reactions or lack of benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fecal Incontinence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FECAL INCONTINENCE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CHU Rennes - Hospital Pontchaillou

    RECRUITING

    Rennes, France

  • CHU de Rouen

    RECRUITING

    Rouen, France

  • Coloproctology Center Takano Hospital

    RECRUITING

    Kumamoto, Japan

    Contact

  • Corporacio Sanitaria Parc Tauli

    RECRUITING

    Barcelona, Spain

  • Danderyd Sjukhus

    RECRUITING

    Danderyd, Sweden

  • Deaconess Hospital Group Croix Saint - Simon

    RECRUITING

    Paris, France, 75020, France

  • Fakultni nem. u sv. Anny v Brne

    RECRUITING

    Brno, Brno, Czechia

  • Heidelberg University, Medical Faculty Mannheim, Department of surgery

    RECRUITING

    Mannheim, Germany

    Contact Phone: •••-•••-••••

  • Hiroshima Memorial Hospital

    RECRUITING

    Hiroshima, Japan

    Contact

  • Hokkaido Railway Company JR Sapporo Hospital

    RECRUITING

    Sapporo, Hokkaido, 060-0033, Japan

    Contact

  • Hosp. General Universitario Morales Meseguer

    RECRUITING

    Murcia, Spain

  • Hospital Bichat - Claude Bernard

    RECRUITING

    Paris, France, 75877, France

  • Hospital de Mataro

    RECRUITING

    Mataró, Spain

    Contact Email: •••••@•••••

  • I.R.C.C.S. Policlinico San Donato

    RECRUITING

    San Donato Milanese, Milano, Italy

    Contact

  • IATROS Medicinski Center

    RECRUITING

    Ljubljana, Osrednjeslovenska, 1000, Slovenia

    Contact

  • IRCCS Ospedale San Raffaele

    RECRUITING

    Milan, Italy

    Contact Phone: •••-•••-••••

  • Japan Post Kyoto Teishin Hospital

    RECRUITING

    Kyoto, 604-8798, Japan

    Contact

  • Jichi Medical University Hospital

    NOT_YET_RECRUITING

    Tochigi, Japan

    Contact

  • Juntendo University Hospital

    RECRUITING

    Tokyo, Japan

    Contact

  • Kurume Hospital

    RECRUITING

    Fukuoka, 839-0865, Japan

    Contact

  • Landeskrankenhaus Hall in Tirol

    RECRUITING

    Hall in Tirol, 6060, Austria

    Contact Phone: •••-•••-••••

  • Luis Garcia Florez

    RECRUITING

    Oviedo, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Magen Darm Zentrum Wiener Platz

    RECRUITING

    Cologne, North Rhine-Westphalia, 51065, Germany

  • Matsushima Hospital

    RECRUITING

    Kanagawa, Japan

    Contact

  • Medical Center Unimed EOOD

    RECRUITING

    Sevlievo, Bulgaria

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Medical University Graz

    RECRUITING

    Graz, Austria

  • Meiwa Hospital

    RECRUITING

    Hyōgo, 663-8186, Japan

    Contact

  • Skånes Universitetssjukhus, Malmo

    RECRUITING

    Malmö, Sweden, Sweden

  • St. Mary's Hospital

    RECRUITING

    London, United Kingdom

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

    RECRUITING

    Krakow, Poland

  • Teikyo University Chiba Medical Center

    RECRUITING

    Chiba, Japan

    Contact

  • The Institute for the Care of Mother and Child

    RECRUITING

    Prague, Czechia

  • Tsujinaka Hospital, Coloproctological Surgery

    RECRUITING

    Chiba, 227-08771, Japan

    Contact

  • Östersund sjukhus, Kirurgiska kliniken

    RECRUITING

    Östersund, Sweden, Sweden

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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