Cure My Disease

Don't miss your cure!

 Log in / Sign up

Muscle cells under the microscope: how does a week of disuse change them?

NCT ID NCT05801185

Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study looks at how different cells in human muscle respond when a leg is completely unloaded for five days. Healthy young adults will use crutches and a special shoe to keep one leg off the ground, mimicking the effects of immobilization. Before and after, researchers will measure muscle size and strength, and take small muscle samples to analyze gene activity in individual cells. The goal is to understand the early molecular changes that lead to muscle loss, which could help design better ways to prevent it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Unilateral lower limb suspension (ULLS) - a procedure where one leg is unloaded for 5 days using crutches and a special shoe
What this could lead to
If successful, this could reveal which muscle cells change during disuse, potentially guiding future strategies to prevent muscle loss in people with injuries or immobilization.
What could go wrong
This is a small, early study in healthy young adults, so findings may not apply to older or ill populations. It is observational and does not test a treatment, so it cannot directly lead to a therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy young adult men and women Exclusion Criteria: * An age younger than 18 or older than 40 years * Contraindications to magnetic resonance imaging (MRI) * Contraindications to maximal intensity resistance exercise * Contraindications to unloading (i.e., ULLS) * Very high physical activity levels (determined using a standard Godin Leisure-Time Exercise Questionnaire (GLTEQ)) * Hypertension (\>140/90 mm Hg) * History of malignancy * History of coagulation dysfunction * History of musculoskeletal or neurological disorders * History of cardiovascular disease * History of cerebrovascular disease * History of respiratory disease * History of gastrointestinal disease * History of renal disease * History of past or present condition requiring long-term drug prescriptions.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Unilateral lower limb suspension are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Unilateral lower limb suspension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Karolinska Institutet

    Huddinge, Stockholm County, 14152, Sweden