Experimental immune cell therapy for AML shows promise but trial halted early

NCT ID NCT04511130

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a treatment called MT-401, which uses specially trained immune cells from a donor to fight acute myeloid leukemia (AML) after a stem cell transplant. The goal was to see if these cells could prevent or treat relapse. The trial enrolled 92 people but was stopped early. The approach aims to control the disease, not cure it, as patients still need ongoing monitoring and care.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio, 44195, United States

  • John Theurer Cancer Center at Hackensack UMC

    Hackensack, New Jersey, 07601, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mayo Clinic Cancer Center-Rochester

    Rochester, Minnesota, 55905, United States

  • Mayo Clinical Cancer Center-Florida

    Jacksonville, Florida, 32224, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Moores Cancer Center at University of Californa San Diego

    La Jolla, California, 92093, United States

  • UCLA Department of Medicine

    Los Angeles, California, 90095, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35249, United States

  • University of Chicago

    Chicago, Illinois, 77027, United States

  • University of Iowa Hospitals & Clinics

    Iowa City, Iowa, 52242, United States

  • Weill Cornell Medicine | NewYork-Presbyterian

    New York, New York, 10027, United States

  • Winship Cancer Institute of Emory University

    Atlanta, Georgia, 303222, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06519, United States