Experimental immune cell therapy for leukemia shows promise but trial halted early

NCT ID NCT04511130

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 21 times

Summary

This study tested a special type of immune cell (MT-401) made from a donor's blood to treat acute myeloid leukemia (AML) after a stem cell transplant. The cells were designed to attack cancer cells while leaving healthy tissue alone. The trial aimed to see if this approach could prevent relapse or treat leukemia that returned after transplant. However, the study was stopped early, so results are limited.

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Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio, 44195, United States

  • John Theurer Cancer Center at Hackensack UMC

    Hackensack, New Jersey, 07601, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mayo Clinic Cancer Center-Rochester

    Rochester, Minnesota, 55905, United States

  • Mayo Clinical Cancer Center-Florida

    Jacksonville, Florida, 32224, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Moores Cancer Center at University of Californa San Diego

    La Jolla, California, 92093, United States

  • UCLA Department of Medicine

    Los Angeles, California, 90095, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35249, United States

  • University of Chicago

    Chicago, Illinois, 77027, United States

  • University of Iowa Hospitals & Clinics

    Iowa City, Iowa, 52242, United States

  • Weill Cornell Medicine | NewYork-Presbyterian

    New York, New York, 10027, United States

  • Winship Cancer Institute of Emory University

    Atlanta, Georgia, 303222, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06519, United States

Conditions

Explore the condition pages connected to this study.