Race against time: new drug trial aims to slow devastating brain disease

NCT ID NCT06706622

Summary

This large, late-stage trial is testing whether a new drug called amlenetug can slow down the progression of multiple system atrophy (MSA), a rare and serious brain disorder. About 357 people with MSA will receive either the drug or a placebo via monthly IV infusions for over a year, with the option to continue on the drug afterward. The main goal is to see if the treatment can delay worsening of symptoms and improve survival.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O.U. Pisana-Ospedale S. Chiara

    Pisa, 56126, Italy

  • AOU Universita della Campania Luigi Vanvitelli

    Naples, 80138, Italy

  • Baylor College Of Medicine

    Houston, Texas, 77030, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • CHU - Hospital de la Timone

    Marseille, 13385, France

  • CenExel Rocky Mountain Clinical Research, LLC

    Englewood, Colorado, 80113, United States

  • Centre Hospitalier Regional Universitaire (CHRU) Montpellier - Hopital Saint-Eloi Guy de Chauliac

    Montpellier, 34295, France

  • Centre Hospitalier Regional Universitaire de Lille - Hopital Roger Salengro

    Lille, 59037, France

  • Centre Hospitalier Universitaire (CHU) de Bordeaux - Groupe Hospitalier Pellegrin

    Bordeaux, 33076, France

  • Centre Hospitalier Universitaire de Toulouse - Hopital Purpan

    Toulouse, 31059, France

  • Chu De La Pitie-Salpetriere

    Paris, 75651, France

  • Cleveland Clinic - Neurological Institute

    Cleveland, Ohio, 44195, United States

  • Clinical Ageing Reseach Unit

    Newcastle upon Tyne, Tyne and Wear, NE4 5LP, United Kingdom

  • Columbia University Medical Center - The Neurological Institute of New York

    New York, New York, 10032-3726, United States

  • Curiositas-ad-sanum Beratungs-und Studien GmbH

    Haag in Oberbayern, 83527, Germany

  • Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    Milan, 20133, Italy

  • Fujita Health University Hospital

    Toyoake, Aichi-ken, 470-1192, Japan

  • Gifu University Hospital

    Gifu, Gifu, 501-1194, Japan

  • Gold Coast Hospital

    Southport, Queensland, 4215, Australia

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-8648, Japan

  • Hospital Clinic de Barcelona - Institut Clinic de Neurociencies (ICN)

    Barcelona, 08036, Spain

  • Hospital Universitario Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen del Rocio (HUVR) - Instituto de Biomedicina de Sevilla (IBIS)

    Seville, 41015, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona (Spain), 08041, Spain

  • IRCCS Institute of Neurological Sciences of Bologna- Universita di Bologna

    Bologna, 40139, Italy

  • Indiana Health University

    Indianapolis, Indiana, 46202, United States

  • Inland Northwest Research

    Spokane, Washington, 99202, United States

  • Johns Hopkins University School of Medicine

    Baltimore, Maryland, 21287, United States

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Keio University Hospital

    Tokyo, 160-8582, Japan

  • Kyung Hee University Hospital

    Seoul, 02447, South Korea

  • Liverpool Hospital - South Western Sydney Local Health District

    Liverpool, New South Wales, 2170, Australia

  • Ludwig-Maximilians-Universitat Munchen Klinikum der Universitat - Grosshadern

    München, 81377, Germany

  • Mayo Clinic

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Movement Disorders Clinic

    Beelitz-Heilstätten, 14547, Germany

  • NYU Medical Center - Dysautonomia center

    New York, New York, 10016, United States

  • National Center Hospital, National Center of Neurology and Psychiatry

    Kodaira-shi, Tokyo, 187-8551, Japan

  • National Hospital Organization Higashinagoya National Hospital

    Nagoya, Aichi-ken, 465-8620, Japan

  • National Hospital Organization Sendai Nishitaga Hospital

    Sendai, Miyagi, 982-8555, Japan

  • Niigata University Medical And Dental Hospital

    Niigata, 9518520, Japan

  • Nuffield Oxford University and Oxford University Hospital NHS Foundation Trusts-John Radcliffe Ho...

    Oxford, Oxfordshire, OX3 9DU, United Kingdom

  • Parkinson's Disease And Movement Disorder Center Of Boca Raton

    Boca Raton, Florida, 33486, United States

  • QUEST Research Institute

    Farmington Hills, Michigan, 48334, United States

  • Queen Elizabeth University Hospital - NHS Greater Glasgow & Clyde

    Glasgow, Scotland, G51 4TF, United Kingdom

  • Royal Devon and Exeter Hospital - Royal Devon University Healthcare NHS Foundation Trust

    Exeter, EX2 5DW, United Kingdom

  • Saitama Medical University Hospital

    Iruma-gun, 350-0495, Japan

  • Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust

    Salford, Greater Manchester, M6 8HD, United Kingdom

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The National Hospital for Neurology and Neurosurgery

    London, WC1N 3BG, United Kingdom

  • The Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 8L6, Canada

  • Toronto Western Hospital (TWH)

    Toronto, Ontario, M5T 2S8, Canada

  • Tottori University Hospital

    Yonago-shi, Tottori, 683-8504, Japan

  • Unite d'investigation clinique de Neurologie Rez-de-jardin-Bloc Hopital CHU Pontchaillou

    Rennes, 35033, France

  • Universita Di Salerno Aou San Giovanni Di Dio E Ruggi D'Aragona

    Salerno, 84100, Italy

  • Universitaetsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitaetsklinikum Muenster

    Münster, 48149, Germany

  • Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bu...

    Valencia, 46026, Spain

  • University Hospital Tuebingen

    Tübingen, 72076, Germany

  • University Nebraska Medical Center

    Omaha, Nebraska, 68198-8440, United States

  • University Of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of California, San Francisco Neurosciences Clinical Research Unit

    San Francisco, California, 94158, United States

  • University of Florida Norman Fixel Institute for Neurological Diseases

    Gainesville, Florida, 32608, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19107, United States

  • University of Texas Southwestern Medical Center ¿ Multiple System Atrophy Clinic

    Dallas, Texas, 75390-8565, United States

  • Vanderbilt University Medical Center-Cognitive and Movement Disorders Group

    Nashville, Tennessee, 37232, United States

  • Westmead Hospital

    Westmead, New South Wales, 2145, Australia

  • Yale New Haven Health

    North Haven, Connecticut, 06473, United States

Conditions

Explore the condition pages connected to this study.