Personalized mRNA shots tested to fight multiple cancers

NCT ID NCT03313778

Summary

This early-stage study is testing the safety and immune response of a personalized mRNA vaccine called mRNA-4157 in people with solid tumors. The vaccine is being tested alone and in combination with standard treatments like chemotherapy and immunotherapy. The goal is to see if the vaccine is safe and can help the body's immune system fight cancer cells.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Angeles Clinic and Research Institute

    Los Angeles, California, 90025, United States

  • Florida Cancer Specialists

    Sarasota, Florida, 34232, United States

  • H Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612-9416, United States

  • Imperial College Healthcare NHS Trust Hammersmith Hospital

    London, W12 0HS, United Kingdom

  • Kindai University Hospital

    Osakasayama-Shi, Ôsaka, 589-0014, Japan

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • NYU Langone Medical Center

    New York, New York, 10016, United States

  • National Cancer Center East

    Kashiwa-Shi, Chiba, 277-8577, Japan

  • National Cancer Center Hospital

    Chuo-Ku, Tokyo, 104-0045, Japan

  • Ninewells Hospital - PPDS

    Dundee, Scotland, DD1 9SY, United Kingdom

  • One Clinical Research Perth

    Nedlands, Western Australia, 6009, Australia

  • Orlando Health Cancer Institute

    Orlando, Florida, 32806, United States

  • Royal Mardsen Sutton

    Sutton, Surrey, SM2 5PT, United Kingdom

  • St Vincents Hospital Sydney

    Darlinghurst, New South Wales, Australia

  • The Cancer Institute Hospital of Japanese Foundation For Cancer Research

    Tokyo, 135-8550, Japan

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195-0001, United States

  • The George Washington Cancer Center

    Washington D.C., District of Columbia, 20037, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15219, United States

  • UT Southwest Medical Center

    Dallas, Texas, 75390, United States

  • Westmead Hospital-Cnr Hawkesbury and Darcy Road

    Westmead, New South Wales, 2145, Australia

Conditions

Explore the condition pages connected to this study.