Smart drug strategy targets hidden cancer cells in young CLL patients
NCT ID NCT05478512
First seen Mar 26, 2026 · Last updated May 07, 2026 · Updated 8 times
Summary
This study tests a personalized treatment plan for young adults (18-65) with high-risk chronic lymphocytic leukemia (CLL) who have not had prior therapy. Patients first receive a combination of two drugs (venetoclax and obinutuzumab). Then, based on whether any cancer cells remain hidden, they either continue with one drug or switch to a different two-drug combo (venetoclax and zanubrutinib) to try to wipe out all traces of the disease. The goal is to tailor treatment to each person's response, potentially reducing long-term medication needs.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ematologia AO di Perugia
Perugia, Italy
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Ematologia AOU Careggi
Florence, Italy
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Ematologia AOUS - Policlinico S. M. alle Scotte
Siena, Italy
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Ematologia IRST D.Amadori
Meldola, Italy
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Ematologia Ospedale Infermi
Rimini, Italy
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Ematologia Ospedale S.M. delle Croci
Ravenna, Italy
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Ematologia Policlinico Gemelli
Roma, Italy
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Ematologia Policlinico Umberto I
Roma, Italy
Conditions
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