New hope for lymphoma patients: drug cocktail aims to control relapsed disease

NCT ID NCT06006117

Recruiting now Disease control Sponsor: The Lymphoma Academic Research Organisation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a combination of two drugs, Mosunetuzumab and Lenalidomide, works better than standard treatments for marginal zone lymphoma that has come back or stopped responding. About 260 adults who have had at least one prior treatment will be randomly assigned to the new combo or one of several standard options. The main goal is to see how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mosunetuzumab and Lenalidomide
What this could lead to: If successful, this combination could offer a new, more effective treatment option for people with marginal zone lymphoma that has returned or not responded to prior therapy.
What could go wrong: This is still an experimental approach; it may not prove better than existing treatments. Side effects from the drug combination could be significant, and long-term outcomes are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Lymphoma, B-Cell, Marginal Zone marginal zone lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MARGINAL ZONE LYMPHOMA

Contacts and locations

Locations

AOU CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO - Ematologia
NOT_YET_RECRUITING

Torino, Italy
APHP - Hôpital Saint Louis
RECRUITING

Paris, France
AZIENDA OSPEDALIERA S. CROCE E CARLE CUNEO - Ematologia
NOT_YET_RECRUITING

Cuneo, Italy
AZIENDA OSPEDALIERO UNIVERITARIA DI MODENA - Ematologia
NOT_YET_RECRUITING

Modena, Italy
CH Saint-Eloi
RECRUITING

Montpellier, France
CH d'Avignon - Hopital Henri Duffaut
RECRUITING

Avignon, France
CH de la Côte Basque - Hôpital de Bayonne
RECRUITING

Bayonne, France
CHR d'Orléans
RECRUITING

Orléans, France
CHRU Besançon - Hôpital Minjoz
RECRUITING

Besançon, France
CHRU de LILLE - Claude Huriez
RECRUITING

Lille, France
CHU Henri Mondor
RECRUITING

Créteil, France
CHU Lyon Sud
RECRUITING

Pierre-Bénite, France
CHU UCL NAMUR - SITE GODINNE - Service Hématologie
NOT_YET_RECRUITING

Yvoir, 5530, Belgium
CHU d'Amiens
RECRUITING

Amiens, France
CHU de Dijon
RECRUITING

Dijon, France
CHU de Grenoble - Hôpital Albert Michallon
RECRUITING

La Tronche, France
CHU de Nancy - Brabois
RECRUITING

Nancy, France, France
CHU de Nantes - Hôtel Dieu
RECRUITING

Nantes, France
CHU de Nice
RECRUITING

Nice, France
CHU de Rennes - Hôpital de Pontchaillou
RECRUITING

Rennes, France
Centre Antoine Lacassagne
RECRUITING

Nice, France
Centre Catherine de Sienne
RECRUITING

Nantes, France
Centre Henri Becquerel
RECRUITING

Rouen, France
Chu Estaing
RECRUITING

Clermont-Ferrand, France
Helios Klinikum Berlin-Buch - Klinik für Hämatologie und Stammzelltransplantation
NOT_YET_RECRUITING

Berlin, Germany
INSTITUT JULES BORDET - Service Hématologie
NOT_YET_RECRUITING

Anderlecht, 1070, Belgium
INSTITUTO ONCOLOGICO VENETO I.R.C.C.S - Ematologia
NOT_YET_RECRUITING

Castelfranco Veneto, Italy
INSTITUTO PORTUGUES DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL - Departamento Hematologia
RECRUITING

Lisbon, 1099, Portugal
Institut Bergonié
RECRUITING

Bordeaux, France
Institut Paoli Calmette
RECRUITING

Marseille, France
Institut de Cancérologie de la Loire Lucien Neuwirth
RECRUITING

Saint-Priest-en-Jarez, France
KLINIKUM DER STADT LUDWIGSHAFEN - Hämatologie
RECRUITING

Ludwigshafen, Germany
KLINIKUM ST. MARIEN AMBERG - Hämatologie/Onkologie
NOT_YET_RECRUITING

Amberg, Germany
MUTTERHAUS DER BORROMAERINNEN - Hämatologie
NOT_YET_RECRUITING

Trier, Germany
OSPEDALE MAGGIORE ASUGI - UCO Ematologia
NOT_YET_RECRUITING

Trieste, Italy
OSPEDALE S. MARIA DELLE CROCI - Dipartimento di Oncologia ed Ematologia
NOT_YET_RECRUITING

Ravenna, Italy
OSPEDALE SAN RAFFAELE - Unità di Ricerca Clinica Linfomi Dipartimento di Onco-ematologia
NOT_YET_RECRUITING

Milan, Italy
OSPEDALE VITO FAZZI LECCE - Hematologia
NOT_YET_RECRUITING

Lecce, Italy
POLICLINICO SAN MATTEO - SC Ematologia
NOT_YET_RECRUITING

Pavia, Italy
POLICLINICO SANT'ORSOLA-MALPIGHI - Ematologia
NOT_YET_RECRUITING

Bologna, Italy
ROBERT BOSCH KRANKENHAUS - Hämatologie, Onkologie und Palliativmedizin
NOT_YET_RECRUITING

Stuttgart, Germany
SAPIENZA UNIVERSIT DI ROMA - POLO PONTINO - OSPEDALE S. MARIA GORETTI LATINA - UOC Ematologia
NOT_YET_RECRUITING

Latina, Italy
UNIV KLINIKUM ULM - INNERE MEDIZIN III - Hämatologie
NOT_YET_RECRUITING

Ulm, Germany
UNIVERSITAETSKLINIKUM SCHLESWIG-HOLSTEIN - Med. Klinik II - Hämatologie und Onkologie
NOT_YET_RECRUITING

Kiel, Germany
UNIVERSITAIR ZIEKENHUIS GENT - Service Hématologie
RECRUITING

Ghent, 9000, Belgium
UNIVERSITATSKLINIKUM REGENSBURG - Klinik für Innere Medizin III
NOT_YET_RECRUITING

Regensburg, Germany
UNIVERSITE CATHOLIQUE DE LOUVAIN SAINT-LUC - Service Hématologie
NOT_YET_RECRUITING

Brussels, 1200, Belgium
UNIVERSITY WURZBURG - Hämatologie
NOT_YET_RECRUITING

Würzburg, Germany

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