New cocktail of cancer drugs shows promise in early lymphoma trial
NCT ID NCT05169515
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing whether combining two existing immunotherapy drugs (mosunetuzumab or glofitamab) with newer oral drugs (iberdomide and/or golcadomide) can safely treat B-cell non-Hodgkin lymphoma that has come back or not responded to previous treatments. About 121 adults with this type of blood cancer will receive these drug combinations to see if they shrink tumors and how well patients tolerate them. The goal is to find better options for people who have run out of standard treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mosunetuzumab, glofitamab, iberdomide, golcadomide
What this could lead to
If successful, this could lead to more effective treatment options for people with B-cell non-Hodgkin lymphoma that has not responded to prior therapies.
What could go wrong
This is an early phase 1 trial with a small number of participants, so safety and effectiveness are not yet proven. The drug combinations may cause significant side effects or fail to improve outcomes.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NON HODGKIN LYMPHOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
ASST Spedali Civili di Brescia
RECRUITINGBrescia, Lombardy, 25123, Italy
-
Azienda Ospedaliero Universitaria Pisana-Ospedale Santa Chia
RECRUITINGPisa, Piedmont, 56126, Italy
-
Center Hospital
RECRUITINGRamat Gan, 5262199, Israel
-
Clinica Universidad de Navarra-Madrid
RECRUITINGMadrid, 28027, Spain
-
Hadassah University Hospital - Ein Kerem
RECRUITINGJerusalem, 9112001, Israel
-
Hosp Universitario Salamanca
RECRUITINGSalamanca, 37007, Spain
-
Hospital General Universitario Gregorio Maranon
RECRUITINGMadrid, 28040, Spain
-
Hospital Universitari Vall d Hebron
RECRUITINGBarcelona, 08035, Spain
-
Hospital Universitario La Fe
RECRUITINGValencia, Valencia, 46026, Spain
-
ICO L'Hospitalet
RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08908, Spain
-
IRCCS Azienda Ospedaliero Universitaria di Bologna
RECRUITINGBologna, Emilia-Romagna, 40138, Italy
-
IRCCS Istituto Romagnolo per lo studio dei tumori "Dino Amadori"
RECRUITINGMeldola, Emilia-Romagna, 47014, Italy
-
Irccs Ospedale San Raffaele
RECRUITINGMilan, Lombardy, 20132, Italy
-
Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28204, United States
-
Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
-
NHS Greater Glasgow and Clyde
RECRUITINGGlasgow, G12 0YN, United Kingdom
-
Nottingham University Hospitals City Campus
RECRUITINGNottingham, NG5 1PB, United Kingdom
-
Oxford University Hospitals NHS Trust - Churchill Hospital
RECRUITINGOxford, OX3 7LE, United Kingdom
-
Rambam Health Care Campus
RECRUITINGHaifa, 3109600, Israel
-
Soroka
RECRUITINGBeersheba, 0084101, Israel
-
Sourasky Medical Center
RECRUITINGTel Aviv, 6423900, Israel
-
The University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
-
UCSF/Hematology, Blood & Marrow Transplant, And Cellular Therapy (HBC) Program
RECRUITINGSan Francisco, California, 94143, United States
-
UT MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
-
University College London Hospitals
RECRUITINGLondon, W1T 7HA, United Kingdom
-
University of Colorado
RECRUITINGAurora, Colorado, 80045, United States