Monthly pill could revolutionize HIV prevention

NCT ID NCT06045507

First seen Jan 09, 2026 · Last updated May 14, 2026 · Updated 25 times

Summary

This study tested a new once-monthly pill, MK-8527, to see if it is safe and how it works in people at low risk for HIV. 352 adults took either the pill or a placebo. The main goal was to check for side effects and how the drug moves through the body.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HIV PRE-EXPOSURE PROPHYLAXIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • Albuquerque Clinical Trials, Inc. ( Site 0044)

    Albuquerque, New Mexico, 87102, United States

  • Bridge HIV- San Francisco Department of Public Health ( Site 0042)

    San Francisco, California, 94102, United States

  • Community Medical Care Center ( Site 0056)

    Immokalee, Florida, 34142, United States

  • Desmond Tutu Health Foundation ( Site 0021)

    Cape Town, Western Cape, 7925, South Africa

  • Fenway Health ( Site 0043)

    Boston, Massachusetts, 02215, United States

  • Fred Hutchinson Cancer Center - The Seattle HIV Vaccine Trials Unit ( Site 0057)

    Seattle, Washington, 98104, United States

  • Hadassah Medical Center ( Site 0002)

    Jerusalem, 9112001, Israel

  • Helen Joseph Hospital ( Site 0024)

    Johannesburg, Gauteng, 2092, South Africa

  • Josha Research ( Site 0023)

    Bloemfontein, Free State, 9301, South Africa

  • Prism Health North Texas, Oak Cliff Health Center ( Site 0045)

    Dallas, Texas, 75208, United States

  • Qhakaza Mbokodo Research Clinic ( Site 0026)

    Ladysmith, KwaZulu-Natal, 3370, South Africa

  • Rambam Health Care Campus ( Site 0003)

    Haifa, 3109601, Israel

  • Sheba Medical Center ( Site 0001)

    Ramat Gan, 5265601, Israel

  • University of Pittsburgh Medical Center-Division of Infectious Diseases ( Site 0041)

    Pittsburgh, Pennsylvania, 15213, United States

  • Velocity Clinical Research Rockville ( Site 0048)

    Rockville, Maryland, 20854, United States

  • Velocity Clinical Research, Hallandale Beach ( Site 0052)

    Hallandale, Florida, 33009, United States

  • Velocity Clinical Research, North Hollywood ( Site 0054)

    North Hollywood, California, 91606, United States

  • Wits RHI-Wits RHI Ward 21 Clinical Research site ( Site 0027)

    Johannesburg, Gauteng, 2000, South Africa

Conditions

Explore the condition pages connected to this study.