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Clear braces take on classic overbite treatment in Head-to-Head trial

NCT ID NCT05950581

Disease control Sponsor: Hama University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a new clear-plate version of the Twin-Block brace against the traditional metal one for children aged 10.5-13 with a receding lower jaw and overbite. The goal is to see if the clear plates work as well at correcting jaw position and bite. Thirty-two participants will wear the device 17 hours daily, and changes in jaw angles and tooth position will be measured.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Modified Twin-Block Appliance with Clear Plates
What this could lead to
If it works, this could offer a more comfortable and less visible option for correcting overbite in children, potentially improving treatment adherence.
What could go wrong
This is a small, early-stage study with only 32 participants, so results may not apply to everyone. The clear plates might be less effective or more fragile than the traditional device.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 13 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Patients with mixed dentition at age 10.5-13 years. * The patient has Skeletal class II malocclusion caused by mandibular retraction ANB \> 5, 8 mm \>O.J\> 5 mm, SNB\<78, angle (NSAr) ≥ ° 125 and normal placement of the upper jaw. * The patient is willing to accept treatment with a removable device. * No previous orthodontic treatment * the growth model is within the normal or horizontal maxillary opening angle of 30 \>MM or angle of 400 \> Björk * patients do not have an upper alveolar dental protrusion. Exclusion Criteria: * -Patients with periodontal disease. * patients with a neuromuscular disorder. * patients of class I or III of malocclusion. * Patients with temporomandibular joint disorder. * Patients with Skeletal open bite. * Patients with poor oral and gingival health * the presence of a unilateral or bilateral posterior crossbite. * patients who have upper jaw stenosis and need to be prepared by expansion before functional treatment. * any patient who does not meet one or more of the Inclusion criteria will be removed from the study.

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Conditions

The condition(s) this trial relates to.

malocclusion due to protuberant upper front teeth Malocclusion, Angle Class II

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malocclusion, angle class II

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Hama University

    RECRUITING

    Hama, Syria

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