Bacteria battle cancer: modified salmonella starves tumors in new trial

NCT ID NCT05103345

Recruiting now Disease control Sponsor: Guangzhou Sinogen Pharmaceutical Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a modified salmonella bacteria (SGN1) injected directly into tumors. The bacteria are designed to grow inside tumors and cut off their food supply (an amino acid called methionine), causing the tumors to shrink. The trial involves about 70 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the best dose, while also seeing if the treatment can control the disease.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

China Medical University Hospital
RECRUITING

Taichung, Taiwan
Guangdong Clifford Hospital
RECRUITING

Guangzhou, Guangdong, 511495, China
Taipei Medical University-Shuang Ho Hospital,Ministry of Health and Welfare
RECRUITING

New Taipei City, 23561, Taiwan
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China

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