Bacteria engineered to starve tumors enters human trials
NCT ID NCT05038150
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a modified salmonella bacteria, called SGN1, in 70 people with advanced solid tumors that have not responded to standard treatments. The bacteria are designed to grow inside tumors and release an enzyme that breaks down methionine, an amino acid tumors need to survive. The main goals are to check safety and see if the treatment can shrink tumors or slow their growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Modified Salmonella Typhimurium SGN1 (a bacteria engineered to deliver an enzyme that breaks down methionine, an amino acid tumors need to grow)
What this could lead to
If it works, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to other therapies.
What could go wrong
This is an early phase 1/2 trial with only 70 participants, so it is too soon to know if it is safe or effective. The bacteria may cause serious side effects, and the approach may not shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Banner MD Anderson Cancer Center
SUSPENDEDGilbert, Arizona, 85234, United States
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Barbara Ann Karmanos Cancer Hospital dba Karmanos Cancer Center
WITHDRAWNDetroit, Michigan, 48201, United States
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Guangdong Clifford Hospital
RECRUITINGGuangzhou, Guangdong, 511495, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Harbin Medical University Cancer Hospital
RECRUITINGHarbin, Heilongjiang, 150081, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Health Chao Family Comprehensive Cancer Center
SUSPENDEDOrange, California, 92868, United States
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Shanghai Jiao Tong University Affiliated Sixth People's Hospital
RECRUITINGShanghai, Shanghai Municipality, 200233, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Cincinnati Cancer Center
SUSPENDEDCincinnati, Ohio, 45267, United States
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West China Hospital of Sichuan University
RECRUITINGChengdu, Sichuan, 610041, China
Contact Phone: •••-•••-•••• Email: •••••@•••••