Bacteria engineered to starve tumors enters human trials

NCT ID NCT05038150

Recruiting now Disease control Sponsor: Guangzhou Sinogen Pharmaceutical Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing a modified salmonella bacteria, called SGN1, in 70 people with advanced solid tumors that have not responded to standard treatments. The bacteria are designed to grow inside tumors and release an enzyme that breaks down methionine, an amino acid tumors need to survive. The main goals are to check safety and see if the treatment can shrink tumors or slow their growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Modified Salmonella Typhimurium SGN1 (a bacteria engineered to deliver an enzyme that breaks down methionine, an amino acid tumors need to grow)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to other therapies.
What could go wrong: This is an early phase 1/2 trial with only 70 participants, so it is too soon to know if it is safe or effective. The bacteria may cause serious side effects, and the approach may not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

Banner MD Anderson Cancer Center
SUSPENDED

Gilbert, Arizona, 85234, United States
Barbara Ann Karmanos Cancer Hospital dba Karmanos Cancer Center
WITHDRAWN

Detroit, Michigan, 48201, United States
Guangdong Clifford Hospital
RECRUITING

Guangzhou, Guangdong, 511495, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, Heilongjiang, 150081, China
Health Chao Family Comprehensive Cancer Center
SUSPENDED

Orange, California, 92868, United States
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200233, China
University of Cincinnati Cancer Center
SUSPENDED

Cincinnati, Ohio, 45267, United States
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China

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